Trial Outcomes & Findings for Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System (NCT NCT03109795)
NCT ID: NCT03109795
Last Updated: 2024-07-29
Results Overview
Aortic stiffness as determined by the carotid-femoral pulse wave velocity technique
Recruitment status
TERMINATED
Study phase
PHASE4
Target enrollment
35 participants
Primary outcome timeframe
4 weeks
Results posted on
2024-07-29
Participant Flow
Participant milestones
| Measure |
Clonidine
To test the magnitude by which short-term (4 weeks) sympathetic nerve activity blockade (clonidine) improves large elastic artery stiffness, vascular inflammation and baroreflex function in subjects with moderate-to-high levels of anxiety
Clonidine Pill: sympathetic nerve activity blockade
|
Hydrochlorothiazide
Hydrochlorothiazide is a blood pressure-lowering control condition to compare to the effects of clonidine
Hydrochlorothiazide: Blood pressure-lowering control condition
|
|---|---|---|
|
Overall Study
STARTED
|
0
|
0
|
|
Overall Study
COMPLETED
|
0
|
0
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
Baseline characteristics by cohort
Baseline data not reported
PRIMARY outcome
Timeframe: 4 weeksPopulation: Study was terminated before any participant was randomized to groups.
Aortic stiffness as determined by the carotid-femoral pulse wave velocity technique
Outcome measures
Outcome data not reported
Adverse Events
Clonidine
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Hydrochlorothiazide
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place