Comparison the Postoperative Quality of Recovery Between Neostigmine and Sugammadex in Elderly Patients Undergoing Trans Pars Plana Vitrectomy With General Anesthesia -Randomized Controlled Trial-
NCT ID: NCT03108989
Last Updated: 2017-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
90 participants
INTERVENTIONAL
2017-02-08
2017-07-25
Brief Summary
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Its benefits over traditional acetylcholinesterase inhibitors have been widely demonstrated in many studies. The scope of such studies has been mostly related to the efficacy of NMB reversal and safety. However, the clinical use of sugammadex led some anaesthesiologists to observe that following the use of this agent, patients seemed to recover consciousness faster and look like they were feeling better. To present, there is little information on the effect of sugammadex on awakening from anaesthesia.
The quality of postoperative recovery focused around patient-oriented endpoints has raised new interest as a measure of the quality of anaesthesia and a target towards which improvement can be directed.
On the other hand, there is no single prospective study performed to address a possible effect of sugammadex on recovery from anaesthesia.
The objective of this study was to compare the effect of sugammadex and neostigmine on the quality of postoperative recovery using the PQRS in elderly patients undergoing trans pars plana vitrectomy with general anesthesia
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Sugammadex group
After the end of surgery, sugammadex of 2 mg/kg will be administered to reverse neuromuscular blockade.
Sugammadex
After the end of surgery, sugammadex of 2 mg/kg will be administered to reverse neuromuscular blockade.
Neostigmine group
After the end of surgery, neostigmine will be administered to reverse neuromuscular blockade.
Neostigmine
After the end of surgery, neostigmine will be administered to reverse neuromuscular blockade.
Interventions
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Sugammadex
After the end of surgery, sugammadex of 2 mg/kg will be administered to reverse neuromuscular blockade.
Neostigmine
After the end of surgery, neostigmine will be administered to reverse neuromuscular blockade.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of malignant hyperthermia
* Significant renal or hepatic dysfunction
* Allergy to sugammadex or rocuronium
* BMI \> 30kg/m2
* History of medication which affect neuromuscular blocker such as anti-convulsants, magnesium
60 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Department of Anesthesiology and Pain Medicine
Seoul, , South Korea
Countries
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References
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Kim NY, Koh JC, Lee KY, Kim SS, Hong JH, Nam HJ, Bai SJ. Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study. J Clin Anesth. 2019 Nov;57:97-102. doi: 10.1016/j.jclinane.2019.02.014. Epub 2019 Mar 30.
Other Identifiers
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4-2015-0641
Identifier Type: -
Identifier Source: org_study_id