Continuation With Vortioxetine in Child and Adolescent Patients With Major Depressive Disorder (MDD) From 7 to 17 Years of Age

NCT ID: NCT03108625

Last Updated: 2021-06-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2020-04-16

Brief Summary

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Evaluation of the long-term safety and tolerability of vortioxetine in child and adolescent patients with a Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5™) diagnosis of MDD

Detailed Description

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Conditions

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Depressive Disorder, Major

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vortioxetine

Once daily dosing of vortioxetine (oral tablets) for 78 weeks.

Group Type EXPERIMENTAL

Vortioxetine

Intervention Type DRUG

Target dose is 10 mg/day; the dose can be down- or uptitrated to 5, 15, or 20 mg/day.

Interventions

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Vortioxetine

Target dose is 10 mg/day; the dose can be down- or uptitrated to 5, 15, or 20 mg/day.

Intervention Type DRUG

Other Intervention Names

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Brintellix Lu AA21004

Eligibility Criteria

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Inclusion Criteria

* The patient is a male or female child aged ≥7 and \<12 years or an adolescent aged ≥12 and ≤17 years at Baseline in Study 12712B.
* The patient must have completed extension Study 12712A immediately prior to enrolment into this extension study.
* The patient had a primary diagnosis of a MDD at entry in Study 12709A or 12710A, diagnosed according to DSM-5™.
* The patient is still indicated for long-term treatment with vortioxetine according to the clinical opinion of the investigator.

Exclusion Criteria

* The patient has been diagnosed with another psychiatric disorder (for example mania, bipolar disorder, schizophrenia or any psychotic disorder) during study 12712A.
* The patient has an attention-deficit/hyperactivity disorder (ADHD) that requires a pharmacological treatment other than a stimulant medication.
Minimum Eligible Age

7 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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H. Lundbeck A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Email contact via H. Lundbeck A/S

Role: STUDY_DIRECTOR

[email protected]

Locations

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MHAT "Targovishte" AD

Targovishte, , Bulgaria

Site Status

DCC Mladost-M

Varna, , Bulgaria

Site Status

Marienthal Center of Psychiatry and Psychology

Tallinn, , Estonia

Site Status

CHU de Nantes - Hopital Hotel Dieu

Nantes, , France

Site Status

Rheinhessen-Fachklinik Mainz, Kinder und Jugendpsychiatri

Mainz, , Germany

Site Status

Vadaskert Alapitvany

Budapest, , Hungary

Site Status

Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza

Gyula, , Hungary

Site Status

Scientific Institute Fondazione Stella Maris

Calambrone, , Italy

Site Status

Universita degli Studi di Messina - Facolta di Medicina e Chirurgia

Messina, , Italy

Site Status

Linda Keruze's Psychiatric Center, LLC

Liepāja, , Latvia

Site Status

Prywatne Gabinety Lekarskie ¿Promedicus¿ Anna Agnieszka Tomczak

Bialystok, , Poland

Site Status

Centrum Badan Klinicznych PI-House Sp. z o.o.

Gdansk, , Poland

Site Status

Przychodnia Syntonia Poradnia Zdrowia Psychicznego

Kielce, , Poland

Site Status

SPECTRUM Centrum Neurologii i Psychiatrii

Lublin, , Poland

Site Status

Filip Rybakowski Specjalistyczna Praktyka Lekarska

Poznan, , Poland

Site Status

Samodzielny Publiczny Zaklad Opieki Zdrowotnej (SPZOZ) - Centrum Neuropsychiatrii "NEUROMED"

Wroclaw, , Poland

Site Status

Specialized Clinical Psychiatric Hospital 1 of the Ministry of Health

Krasnodar, , Russia

Site Status

Lipetsk Regional Psychoneurological Hospital

Lipetsk, , Russia

Site Status

Nizhny Novgorod Region State Institution Of Healthcare

Nizhny Novgorod, , Russia

Site Status

Medicorehabilitation Research Center "Phoenix"

Rostov-on-Don, , Russia

Site Status

Rostov State Medical University of the Minzdravsotsrazvitiya of Russia

Rostov-on-Don, , Russia

Site Status

Guz "Saratov Regional Psychiatric Hospital St. Sofii"

Saratov, , Russia

Site Status

Saratov State Medical University

Saratov, , Russia

Site Status

State Budgetary Healthcare Institution

Tonnel'nyy, , Russia

Site Status

State Budgetary Healthcare Institution of Sverdlovsk Region

Yekaterinburg, , Russia

Site Status

Clinic of Neurology and Psychiatry for Children and Adolescents

Belgrade, , Serbia

Site Status

Clinical Center of Vojvodina - Clinic of Psychiatry

Novi Sad, , Serbia

Site Status

Cape Trial Centre

Bellville, , South Africa

Site Status

Hospital General Universitario Gregorio Maranon

Madrid, , Spain

Site Status

Unidad de Salud Mental Infanto-Juvenil (USMI-J) Edificio de Consultas Externas. Hospital MarAtimo

Torremolinos, , Spain

Site Status

Alder Hey Childrens Hospital

Liverpool, , United Kingdom

Site Status

Countries

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Bulgaria Estonia France Germany Hungary Italy Latvia Poland Russia Serbia South Africa Spain United Kingdom

Other Identifiers

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2015-002658-11

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

12712B

Identifier Type: -

Identifier Source: org_study_id

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