Conbercept Ophthalmic Injection for Patients With Macular Edema Caused by Branch Retinal Vein Occlusion

NCT ID: NCT03108352

Last Updated: 2022-07-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 255 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-04-13
• Study Completion Date: 2020-10-16

Brief Summary

The purpose of this study is to verify the efficacy and safety of intravitreal injection of conbercept in patients with macular edema (ME) caused by branch retinal vein occlusion (BRVO).

Conditions

Branch Retinal Vein Occlusion; Macular Edema

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Conbercept ophthalmic injection

Conbercept ophthalmic injection

Group Type: EXPERIMENTAL

Conbercept ophthalmic injection

Intervention Type: DRUG

Conbercept ophthalmic injection at a dose of 0.5 mg every month(day0-month 5); If sbujects meets the criteria for repeated administration, the subject receives 0.5 mg Conbercept injection into the study eye (Month 6 \~ 11)

Sham Comparator

sham / Conbercept ophthalmic injection

Group Type: SHAM_COMPARATOR

Conbercept ophthalmic injection

Intervention Type: DRUG

Conbercept ophthalmic injection at a dose of 0.5 mg every month(day0-month 5); If sbujects meets the criteria for repeated administration, the subject receives 0.5 mg Conbercept injection into the study eye (Month 6 \~ 11)

sham/Conbercept ophthalmic injection

Intervention Type: OTHER

Sham injection every month (Day 0 - Month 5); 0.5 mg Conbercept ophthalmic injection in month 6; If sbujects meets the criteria for repeated administration, the subject receives 0.5 mg Conbercept injection into the study eye (Month 7 \~ 11)

Interventions

Conbercept ophthalmic injection

Conbercept ophthalmic injection at a dose of 0.5 mg every month(day0-month 5); If sbujects meets the criteria for repeated administration, the subject receives 0.5 mg Conbercept injection into the study eye (Month 6 \~ 11)

Intervention Type: DRUG

sham/Conbercept ophthalmic injection

Sham injection every month (Day 0 - Month 5); 0.5 mg Conbercept ophthalmic injection in month 6; If sbujects meets the criteria for repeated administration, the subject receives 0.5 mg Conbercept injection into the study eye (Month 7 \~ 11)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients have signed informed consent form and agreed to be followed up as per the trial protocol;
• Aged ≥ 18 years, male or female;
• Study eyes must meet all of following requirements:

• Suffering from macular edema secondary to BRVO that involves the fovea and BRVO has been first diagnosed within previous 12 months;
• Best corrected visual acuity (BCVA) ≥24 and ≤73 letters (Snellen equivalent is 20/320 - 20/40);
• Central retinal thickness (CRT) on OCT is ≥300 μm;
• Without opacities in the refractive media and pupillary miosis that affects fundus examination.

Exclusion Criteria

Any subject who has any of the following ocular condition:

1. Eye of interest

• Has active retina and/or iris neovascularization;
• Has macular epiretinal membranes or vitreous tractions which are considered to influence the central visual acuity by the researcher;
• Has other diseases which are considered to influence the macular functional recovery by the researcher, e.g., foveal atrophy, subfoveal hemorrhage, macular hard exudates or dense submacular hard exudates;
• Has a history of any type of retinal detachment;
• Has non-RVO ocular diseases which are considered to possibly cause macular edema, declined visual acuity or retinal neovascularization during the study period by the researcher, e.g., wet AMD, diabetic retinopathy, uveitis/other intraocular inflammatory diseases, neovascular glaucoma and cystoid macular edema;
• Is considered to require cataract surgery in the next 12 months by the researcher;
• Has received intravitreal injection of corticosteroids within three months before screening, subconjunctival injection of corticosteroids within six months, or local treatment with ocular corticosteroids within one month;
• Has received the following ophthalmic operations: scleral buckling, verteporfin-photodynamic therapy (PDT), vitrectomy, radial optic neurotomy/optic nerve sheathotomy, glaucoma filtration, parafoveal laser photocoagulation, pan-retinal photocoagulation, and macular translocation;
• Has received YAG laser treatment or any other ophthalmic treatments (including cataract surgery, macular grid laser photocoagulation, local retinal photocoagulation, and keratoplasty) within three months before screening;
• Has a BCVA increment by more than 10 alphabets during the screening period (BCVA tested within 24 hours before medication at Day 0 versus BCVA at the time of screening);
• Has aphakic eye (excluding pseudophakic) or or posterior lens capsule (except YAG laser posterior capsulotomy after intraocular lens implantation);

2. Either eye:

• Has active periocular or ocular inflammation (e.g., blepharitis, infective conjunctivitis, keratitis, scleritis, uveitis, and endophthalmitis);
• Has previous or existing uncontrollable glaucoma (defined as IOP remaining at ≥ 30 mmHg after anti-glaucoma treatment), or has a cup-to-disc ratio of the eye of interest of above 0.8 due to severe glaucoma;
• Has received intravitreal injection of any anti-VEGF agents (e.g.,ranibizumab, bevacizumab, and conbercept) within three months before screening;

Patient with any of the following systemic diseases:

• Has a history of anaphylaxis and allergy to fluorescein sodium, and of allergy to protein products for diagnosis or treatment, and is allergic to no less than two drugs and/or non-drug factors, or suffers from allergic diseases now;
• Has a history of stroke, has a history of myocardial and/or cerebral infarction(s) and of transient cerebral ischemia within 6 months before screening, and has active and disseminated intravascular coagulation and distinct bleeding tendency;
• Has confirmed systemic immune disease (e.g., ankylosing spondylitis, systemic lupus erythematosus, and Behcet's disease, rheumatoid arthritis, and scleroderma);
• Has any uncontrollable clinical problem (e.g., AIDS, active hepatitis, severe mental, neurological, cardiovascular and respiratory diseases, and malignancies);
• Hyperpietics with poor blood pressure control (defined as SBP remaining at ≥ 160 mmHg or DBP remaining ≥ 100 mmHg after antihypertensives therapy);
• Has a surgical history within one month before screening, and/or has unhealed wounds, ulcers and fractures at present;
• Has systemically used corticosteroids (orally, intramuscularly, intravenously) within 6 months before screening;
• Has received systemic treatment with anti-VEGF agent(s) (e.g., bevacizumab) within 6 months before screening; Patients with any of the following abnormal laboratory tests
• Those who have hepatic, renal and immunologic dysfunction (this trial specifies that ALT and AST are twice as high as the ULN of this central laboratory, and that Crea and BUN are 1.5-fold as high as the ULN of this central laboratory);
• Those who have coagulation abnormalities (PT is 3 seconds greater than or equal to the ULN, and APTT is 10 seconds greater than or equal to the ULN); Patients of childbearing age with any of the following condition
• Those who do not take effective contraceptive measures at childbearing age; Note: The following conditions are not included in the exclusion range.

1. Amenorrhea for 12 months under the natural condition, or amenorrhea for 6 months under the natural condition and the serum FSH level of < 40 mIU/ml;

2. Six weeks after bilateral ovariectomy with/without hysterectomy;

3. Use of the following one or more acceptable contraceptions:

• Sterilization (for males, with bilateral vasoligation and vasectomy)
• Hormonal contraception (implantable, patchable, oral)
• Intrauterine device and dural barrier method

4. Ability to take reliable contraceptive measures over the study period and hold on to 30 days after study drug withdrawal (unacceptable contraceptive methods include: periodic continence - according to the calendar and ovulatory phase, body thermometry, post-ovulatory method, and coitus interruptus);

• Pregnant women and breastfeeding mothers (in this trial pregnancy is defined as positive U-HCG); Others
• Patient has participated in any drug (not including vitamins and minerals) clinical trial three months before screening (if the study drug has a long half-life, i.e., its five half-lives exceed three months, then it is deemed as five half-lives); Any condition in which the researcher deems necessary to be excluded in the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chengdu Kanghong Biotech Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

The General Hospital of the People's Liberation Army

Beijing, Beijing Municipality, China

Beijing Friendship Hospital, Capital Medical University

Beijing, , China

Beijing Tongren Hospital, Capital Medical University

Beijing, , China

Peking Union Medical College Hospital

Beijing, , China

Peking University First Hospital

Beijing, , China

Peking University People's Hospital

Beijing, , China

Peking University Third Hospital

Beijing, , China

The Second Hospital of Jilin University

Changchun, , China

The Second Xiangya Hospital of Central South University

Changsha, , China

West China Hospital Sichuan University

Chengdu, , China

Army Medical Center

Chongqing, , China

The Second Hospital of Dalian Medical University

Dalian, , China

Zhongshan Ophthalmic Center, Sun Yat-Sen University

Guangzhou, , China

The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, , China

The 2nd Affiliated Hospital of Harbin Medical University

Harbin, , China

The Jiangxi Provincial People's Hospital

Nanchang, , China

Jiangsu Province Hospital

Nanjing, , China

Nanjing First Hospital

Nanjing, , China

The First Affiliated Hospital of Guangxi Medical University

Nanning, , China

Eye & Ent Hospital of Fudan University

Shanghai, , China

Shanghai General Hospital

Shanghai, , China

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, , China

Zhongshan Hospital

Shanghai, , China

The First Hospital of China Medical University

Shenyang, , China

Tianjin Medical University Eye Hospital School of Optometry & Eye Institute

Tianjin, , China

Tianjin Eye Hospital

Tianjing, , China

The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, , China

Eye Hospital,WMU Zhejiang Eye Hospital

Wenzhou, , China

Wuhan General Hospital of Guangzhou Military Command

Wuhan, , China

Wuxi No.2 People's Hospital

Wuxi, , China

The First Affiliated Hospital of Xi'An

Xi'an, , China

Countries

China

References

Shalchi Z, Mahroo O, Bunce C, Mitry D. Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion. Cochrane Database Syst Rev. 2020 Jul 7;7(7):CD009510. doi: 10.1002/14651858.CD009510.pub3.

Reference Type: DERIVED

PMID: 32633861 (View on PubMed)

Other Identifiers

KH902-BRVO-CRP-1.0

Identifier Type: -

Identifier Source: org_study_id