IDOMENEO - Is Treatment Reality in Vascular Medicine Evidence-based and Follows Guideline Recommendations? A Project for Quality Development Exemplified by Peripheral Arterial Disease (PAD)

NCT ID: NCT03098290

Last Updated: 2022-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5608 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-01

Study Completion Date

2021-04-01

Brief Summary

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The prevalence of peripheral arterial disease (PAD) and the proportion of endovascular procedures for treatment are increasing worldwide. For many cases of treatment or procedures no randomized controlled trials (RCT) or results from meta-analyses are so far available. The decision for treatment and selection of procedure is therefore not uncommonly left up to the personal expertise of the physician. The IDOMENEO study represents a multistage multimethodological project for healthcare research and quality assurance in interdisciplinary vascular medicine, which undertakes a comprehensive examination of this topic. Various methods and data sources (even routine data) are linked in a meaningful way. The essential components of the total project are implementation of a register platform (GermanVasc), which conforms to data protection and data security as well as the development of instruments for valid measurement of the quality of life of patients with PAD. The data protection-conform linking of primary data in the register and routine data of the consortium partner BARMER should also enable validation of the data sources.

Detailed Description

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Conditions

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Symptomatic Peripheral Arterial Disease Occlusive Disease of Artery of Lower Extremity Quality of Life

Keywords

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GermanVasc Peripheral Arterial Disease IDOMENEO Routine Data Registry Data Data Validity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Intermittent Claudication

Mild to severe claudication

Catheter-based endovascular revascularization

Intervention Type PROCEDURE

(e.g. PTA-alone, Bare-Metal or Drug-Eluting-Stent, Covered Stent, Atherectomy, Mechanical Thrombectomy, Scoring Ballon, Cutting Ballon)

Bypass-Surgery

Intervention Type PROCEDURE

Venous or alloplastic or comparable Bypass

Endarterectomy

Intervention Type PROCEDURE

Endarterectomy, Patchplasty

Ischaemic Rest Pain

Catheter-based endovascular revascularization

Intervention Type PROCEDURE

(e.g. PTA-alone, Bare-Metal or Drug-Eluting-Stent, Covered Stent, Atherectomy, Mechanical Thrombectomy, Scoring Ballon, Cutting Ballon)

Bypass-Surgery

Intervention Type PROCEDURE

Venous or alloplastic or comparable Bypass

Endarterectomy

Intervention Type PROCEDURE

Endarterectomy, Patchplasty

Critical Limb Threatening Ischaemia

Ulcers, Necrosis, Gangrene

Catheter-based endovascular revascularization

Intervention Type PROCEDURE

(e.g. PTA-alone, Bare-Metal or Drug-Eluting-Stent, Covered Stent, Atherectomy, Mechanical Thrombectomy, Scoring Ballon, Cutting Ballon)

Bypass-Surgery

Intervention Type PROCEDURE

Venous or alloplastic or comparable Bypass

Endarterectomy

Intervention Type PROCEDURE

Endarterectomy, Patchplasty

Interventions

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Catheter-based endovascular revascularization

(e.g. PTA-alone, Bare-Metal or Drug-Eluting-Stent, Covered Stent, Atherectomy, Mechanical Thrombectomy, Scoring Ballon, Cutting Ballon)

Intervention Type PROCEDURE

Bypass-Surgery

Venous or alloplastic or comparable Bypass

Intervention Type PROCEDURE

Endarterectomy

Endarterectomy, Patchplasty

Intervention Type PROCEDURE

Other Intervention Names

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ER Bypass TEA

Eligibility Criteria

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Inclusion Criteria

* Symptomatic peripheral artery disease (intermittent claudication or critical limb ischemia)
* Invasive treatment (open-surgical or endovascular)
* Informed consent was obtained

Exclusion Criteria

* No informed consent was obtained
* Acute limb ischemia without any chronic symptomatic PAD
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GermanVasc

OTHER

Sponsor Role collaborator

University Heart Center Hamburg

UNKNOWN

Sponsor Role collaborator

BARMER GEK Germany

UNKNOWN

Sponsor Role collaborator

University of Hamburg-Eppendorf

OTHER

Sponsor Role collaborator

Universitätsklinikum Hamburg-Eppendorf

OTHER

Sponsor Role lead

Responsible Party

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Christian-Alexander Behrendt

Assoc. Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Christian-Alexander Behrendt, Dr.

Role: PRINCIPAL_INVESTIGATOR

Universitätsklinikum Hamburg-Eppendorf

Locations

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Zentralklinik Bad Berka GmbH

Bad Berka, , Germany

Site Status

Herz- und Gefäßzentrum Bad Bevensen

Bad Bevensen, , Germany

Site Status

Universitäts-Herzzentrum Freiburg - Bad Krozingen (UHZ)

Bad Krozingen, , Germany

Site Status

Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin

Berlin, , Germany

Site Status

HELIOS Klinikum Berlin-Buch

Berlin, , Germany

Site Status

Asklepios Klinik Birkenwerder

Birkenwerder, , Germany

Site Status

St. Josef Hospital I Katholisches Klinikum der Ruhr-Universität Bochum

Bochum, , Germany

Site Status

Gemeinschaftskrankenhaus Bonn, Haus St. Petrus

Bonn, , Germany

Site Status

GFO Kliniken Bonn, Betriebsstätte St. Marien

Bonn, , Germany

Site Status

Klinikum Chemnitz gGmbH

Chemnitz, , Germany

Site Status

Carl-Thiem-Klinikum Cottbus

Cottbus, , Germany

Site Status

Klinikum Darmstadt GmbH

Darmstadt, , Germany

Site Status

Städtisches Klinikum Dresden Friedrichstadt

Dresden, , Germany

Site Status

University Medical Center Düsseldorf

Düsseldorf, , Germany

Site Status

HELIOS Klinikum Erfurt

Erfurt, , Germany

Site Status

Elisabeth-Krankenhaus Essen

Essen, , Germany

Site Status

Universitäts-Herzzentrum Freiburg - Bad Krozingen (UHZ)

Freiburg im Breisgau, , Germany

Site Status

Klinikum Fulda

Fulda, , Germany

Site Status

University Heart Center Hamburg

Hamburg, , Germany

Site Status

Agaplesion Diakonieklinikum Hamburg

Hamburg, , Germany

Site Status

SRH-Klinikum-Karlsbad-Langensteinbach

Karlsbach, , Germany

Site Status

Klinikum Karlsruhe

Karlsruhe, , Germany

Site Status

Agaplesion Diakonie Kliniken Kassel

Kassel, , Germany

Site Status

St. Bonifatius Hospital Lingen

Lingen, , Germany

Site Status

Universitätsklinikum Schleswig-Holstein, Campus Lübeck

Lübeck, , Germany

Site Status

Klinikum Magdeburg gGmbH

Magdeburg, , Germany

Site Status

Theresienkrankenhaus Mannheim

Mannheim, , Germany

Site Status

Kliniken Maria Hilf GmbH

Mönchengladbach, , Germany

Site Status

Ev. Krankenhaus Mühlheim an der Ruhr

Mühlheim, , Germany

Site Status

Isarklinikum München

München, , Germany

Site Status

Klinikum Peine

Peine, , Germany

Site Status

Imland Kliniken Rendsburg

Rendsburg, , Germany

Site Status

Klinikum Rheine I Mathias Spital

Rheine, , Germany

Site Status

Klinikum Stadt Soest

Soest, , Germany

Site Status

Klinikum Mutterhaus der Borromäerinnen gGmbH (Mitte)

Trier, , Germany

Site Status

Countries

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Germany

References

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Behrendt CA, Riess H, Harter M, Kriston L, Federrath H, Marschall U, Debus ES. [Guideline recommendations and quality indicators for invasive treatment of peripheral arterial disease in Germany : The IDOMENEO study for quality improvement and research in vascular medicine]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Feb;61(2):218-223. doi: 10.1007/s00103-017-2676-9. German.

Reference Type BACKGROUND
PMID: 29230514 (View on PubMed)

Behrendt CA, Härter M, Kriston L, Federrath H, Marschall U, Straub C, Debus ES. [IDOMENEO - Does treatment reality in vascular medicine conform to guidelines and treatment?] Gefaesschirurgie. 2017;22(1):41-47.

Reference Type BACKGROUND

Behrendt CA, Pridohl H, Schaar K, Federrath H, Debus ES. [Clinical registers in the twenty-first century : Balancing act between data protection and feasibility?]. Chirurg. 2017 Nov;88(11):944-949. doi: 10.1007/s00104-017-0542-9. German.

Reference Type BACKGROUND
PMID: 29079875 (View on PubMed)

Behrendt CA, Heidemann F, Haustein K, Grundmann RT, Debus ES; PSI Collaborators. Percutaneous endovascular treatment of infrainguinal PAOD: Results of the PSI register study in 74 German vascular centers. Gefasschirurgie. 2017;22(Suppl 1):17-27. doi: 10.1007/s00772-016-0202-2. Epub 2016 Oct 28.

Reference Type BACKGROUND
PMID: 28715513 (View on PubMed)

Behrendt CA, Bertges D, Eldrup N, Beck AW, Mani K, Venermo M, Szeberin Z, Menyhei G, Thomson I, Heller G, Wigger P, Danielsson G, Galzerano G, Lopez C, Altreuther M, Sigvant B, Riess HC, Sedrakyan A, Beiles B, Bjorck M, Boyle JR, Debus ES, Cronenwett J. International Consortium of Vascular Registries Consensus Recommendations for Peripheral Revascularisation Registry Data Collection. Eur J Vasc Endovasc Surg. 2018 Aug;56(2):217-237. doi: 10.1016/j.ejvs.2018.04.006. Epub 2018 May 30.

Reference Type BACKGROUND
PMID: 29776646 (View on PubMed)

Riess HC, Debus ES, Schwaneberg T, Hischke S, Maier J, Bublitz M, Kriston L, Harter M, Marschall U, Zeller T, Schellong SM, Behrendt CA. Indicators of outcome quality in peripheral arterial disease revascularisations - a Delphi expert consensus. Vasa. 2018 Oct;47(6):491-497. doi: 10.1024/0301-1526/a000720. Epub 2018 Jun 1.

Reference Type BACKGROUND
PMID: 29856270 (View on PubMed)

Behrendt CA, Peters F, Mani K. The Swinging Pendulum of Evidence: Is There a Reality Behind Results from Randomised Trials and Real World Data? Lessons Learned from the Paclitaxel Debate. Eur J Vasc Endovasc Surg. 2020 Apr;59(4):510-511. doi: 10.1016/j.ejvs.2020.01.029. Epub 2020 Feb 20. No abstract available.

Reference Type BACKGROUND
PMID: 32088069 (View on PubMed)

Hischke S, Riess HC, Bublitz MK, Kriston L, Schwaneberg T, Harter M, Bertges D, S Debus E, Behrendt CA. Quality Indicators in Peripheral Arterial Occlusive Disease Treatment: A Systematic Review. Eur J Vasc Endovasc Surg. 2019 Nov;58(5):738-745. doi: 10.1016/j.ejvs.2019.06.029. Epub 2019 Sep 13.

Reference Type BACKGROUND
PMID: 31526633 (View on PubMed)

Kaschwich M, Behrendt CA, Heydecke G, Bayer A, Debus ES, Seedorf U, Aarabi G. The Association of Periodontitis and Peripheral Arterial Occlusive Disease-A Systematic Review. Int J Mol Sci. 2019 Jun 15;20(12):2936. doi: 10.3390/ijms20122936.

Reference Type BACKGROUND
PMID: 31208079 (View on PubMed)

Behrendt CA, Schwaneberg T, Hischke S, Muller T, Petersen T, Marschall U, Debus S, Kriston L. Data Privacy Compliant Validation of Health Insurance Claims Data: the IDOMENEO Approach. Gesundheitswesen. 2020 Mar;82(S 02):S94-S100. doi: 10.1055/a-0883-5098. Epub 2019 May 23.

Reference Type BACKGROUND
PMID: 31121613 (View on PubMed)

Behrendt CA, Bjorck M, Schwaneberg T, Debus ES, Cronenwett J, Sigvant B; Acute Limb Ischaemia Collaborators. Editor's Choice - Recommendations for Registry Data Collection for Revascularisations of Acute Limb Ischaemia: A Delphi Consensus from the International Consortium of Vascular Registries. Eur J Vasc Endovasc Surg. 2019 Jun;57(6):816-821. doi: 10.1016/j.ejvs.2019.02.023. Epub 2019 May 22.

Reference Type BACKGROUND
PMID: 31128987 (View on PubMed)

Debus ES, Kriston L, Schwaneberg T, Hischke S, Riess HC, Harter M, Marschall U, Federrath H, Behrendt CA. Rationale and methods of the IDOMENEO health outcomes of the peripheral arterial disease revascularisation study in the GermanVasc registry. Vasa. 2018 Oct;47(6):499-505. doi: 10.1024/0301-1526/a000730. Epub 2018 Aug 16.

Reference Type BACKGROUND
PMID: 30113269 (View on PubMed)

Aarabi G, Raedel M, Kreutzburg T, Hischke S, Debus ES, Marschall U, Seedorf U, Behrendt CA. Periodontal treatment and peripheral arterial disease severity - a retrospective analysis of health insurance claims data. Vasa. 2020 Mar;49(2):128-132. doi: 10.1024/0301-1526/a000846. Epub 2020 Jan 27.

Reference Type RESULT
PMID: 31983289 (View on PubMed)

Behrendt CA, Sedrakyan A, Peters F, Kreutzburg T, Schermerhorn M, Bertges DJ, Larena-Avellaneda A, L'Hoest H, Kolbel T, Debus ES. Editor's Choice - Long Term Survival after Femoropopliteal Artery Revascularisation with Paclitaxel Coated Devices: A Propensity Score Matched Cohort Analysis. Eur J Vasc Endovasc Surg. 2020 Apr;59(4):587-596. doi: 10.1016/j.ejvs.2019.12.034. Epub 2020 Jan 8.

Reference Type RESULT
PMID: 31926836 (View on PubMed)

Kreutzburg T, Peters F, Riess HC, Hischke S, Marschall U, Kriston L, L'Hoest H, Sedrakyan A, Debus ES, Behrendt CA. Editor's Choice - Comorbidity Patterns Among Patients with Peripheral Arterial Occlusive Disease in Germany: A Trend Analysis of Health Insurance Claims Data. Eur J Vasc Endovasc Surg. 2020 Jan;59(1):59-66. doi: 10.1016/j.ejvs.2019.08.006. Epub 2019 Nov 16.

Reference Type RESULT
PMID: 31744786 (View on PubMed)

Kotov A, Peters F, Debus ES, Zeller T, Heider P, Stavroulakis K, Remig J, Gussmann A, Hoffmann J, Friedrich O, Nolte T, Behrendt CA. The prospective GermanVasc cohort study. Vasa. 2021 Nov;50(6):446-452. doi: 10.1024/0301-1526/a000966. Epub 2021 Jul 19.

Reference Type RESULT
PMID: 34279120 (View on PubMed)

Peters F, Behrendt CA; IDOMENEO Collaborators. Limb Related Outcomes of Endovascular vs. Open Surgical Revascularisation in Patients with Peripheral Arterial Occlusive Disease: A Report from the Prospective GermanVasc Cohort Study. Eur J Vasc Endovasc Surg. 2023 Jul;66(1):85-93. doi: 10.1016/j.ejvs.2023.03.040. Epub 2023 Mar 25.

Reference Type DERIVED
PMID: 36972814 (View on PubMed)

Related Links

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http://idomeneo.de

Project website (German)

http://germanvasc.de

Website of the research group leading the project

Other Identifiers

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01VSF16008

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

01VSF18035

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

DRKS00014649

Identifier Type: OTHER

Identifier Source: secondary_id

VF1_2016-028

Identifier Type: -

Identifier Source: org_study_id