Effect of Plum-blossom Needle vs. Tropicamide Eye Drops on Juvenile Myopia

NCT ID: NCT03097198

Last Updated: 2017-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

98 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-12-31

Study Completion Date

2018-12-31

Brief Summary

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The purpose of this study is to determine whether plum-blossom needle is effective in the treatment of juvenile myopia and compare the efficacy with Tropicamide Eye Drops.

Detailed Description

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Plum-blossom needle is a historical treatment technology of Traditional Chinese Medicine, and has been applied to ophthalmic diseases, such as myopia and glaucoma, for nearly one hundred years.

Conditions

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Myopia

Keywords

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Juvenile Traditional Chinese Medicine Plum-blossom needle

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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PbN-TED

Treated with plum-blossom needle first for 10 times during 20 days, followed with a one-month wash-out period and a 10-day period with Tropicamide Eye Drops.

Group Type EXPERIMENTAL

Plum-blossom Needle

Intervention Type OTHER

* acupoint selection: Zhengguang 1, Zhengguang 2, GB20, GV14, LI4.
* plum-blossom needle manipulation methods: After the skin has been wiped with 75 % alcohol, plum-blossom needles will be tapped perpendicularly on the skin at the selected acupoints with wrist force and then lifted immediately. Each point will be tapped repeatedly for 20 to 50 times and both sides of cervical vertebra and temporal region, Suprao-infraorbital margin will be tapped repeatedly. Acupuncturists should tap the points gently to make patients feel only a little pain and stop when the skin gets flushed but is not bleeding.

Tropicamide Eye Drops

Intervention Type DRUG

Instill one drop in both eyes every night before bed.

TED-PbN

Treated with Tropicamide Eye Drops for 10 days first, followed with a one-month wash-out period and 10 times of plum-blossom needle treatment for 20 days.

Group Type EXPERIMENTAL

Plum-blossom Needle

Intervention Type OTHER

* acupoint selection: Zhengguang 1, Zhengguang 2, GB20, GV14, LI4.
* plum-blossom needle manipulation methods: After the skin has been wiped with 75 % alcohol, plum-blossom needles will be tapped perpendicularly on the skin at the selected acupoints with wrist force and then lifted immediately. Each point will be tapped repeatedly for 20 to 50 times and both sides of cervical vertebra and temporal region, Suprao-infraorbital margin will be tapped repeatedly. Acupuncturists should tap the points gently to make patients feel only a little pain and stop when the skin gets flushed but is not bleeding.

Tropicamide Eye Drops

Intervention Type DRUG

Instill one drop in both eyes every night before bed.

Interventions

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Plum-blossom Needle

* acupoint selection: Zhengguang 1, Zhengguang 2, GB20, GV14, LI4.
* plum-blossom needle manipulation methods: After the skin has been wiped with 75 % alcohol, plum-blossom needles will be tapped perpendicularly on the skin at the selected acupoints with wrist force and then lifted immediately. Each point will be tapped repeatedly for 20 to 50 times and both sides of cervical vertebra and temporal region, Suprao-infraorbital margin will be tapped repeatedly. Acupuncturists should tap the points gently to make patients feel only a little pain and stop when the skin gets flushed but is not bleeding.

Intervention Type OTHER

Tropicamide Eye Drops

Instill one drop in both eyes every night before bed.

Intervention Type DRUG

Other Intervention Names

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Double head dermal needles (HWATO, China) 6ml:30mg(0.5%)(FREDA, China)

Eligibility Criteria

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Inclusion Criteria

* The result of retinoscopy is myopic refractive error, near visual acuity and other visual functions must be normal
* Distance visual acuity can be corrected to normal using negative spherical or cylindrical lenses
* Myopia diopter spherical lenses must be ≤-3.00 D which measured under cycloplegia
* Subjects must be between 8 and 20 years of age

Exclusion Criteria

* Diopter spherical lenses be \>-3.00 D , or uncorrected distance visual acuity \<0.1, or pathologic myopia with eye complications
* Diopter spherical lense ≥1.50 D or cylindrical lenses ≥1.00 D, as measured under cycloplegia
* The affected eyes have other diseases which affect the determination of acupuncture efficacy
* Subjects with serious systemic diseases, such as cerebrovascular, liver, kidney, hematopoietic system, and psychiatric diseases
* Longterm use of other related drugs or treatments, which have not been terminated
* Parents or subjects refuse to participate this trial
* Participating other ongoing clinical trials
Minimum Eligible Age

8 Years

Maximum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wenzhou Medical University

OTHER

Sponsor Role lead

Responsible Party

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Tang Lewei

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yuanbo Liang, Doctor

Role: STUDY_DIRECTOR

Clinical&Epidemiological Eye Research Center

Locations

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School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University

Wenzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lewei Tang, Doctor

Role: CONTACT

Phone: +86 15869627364

Email: [email protected]

Facility Contacts

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Lewei Tang, Doctor

Role: primary

References

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Chen L, Liang Y, Xu M, Zheng J, Yu H, Tang L. Effect of plum-blossom needling versus tropicamide eye drops on adolescent myopia: protocol for a randomized crossover trial. J Tradit Chin Med. 2020 Apr;40(2):333-339.

Reference Type DERIVED
PMID: 32242400 (View on PubMed)

Other Identifiers

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2016ZB080

Identifier Type: -

Identifier Source: org_study_id