Development of a Musculoskeletal Model of the PIP Joint

NCT ID: NCT03094962

Last Updated: 2018-11-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-01-21
• Study Completion Date: 2017-09-05

Brief Summary

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Conditions

Patient Specific Computational Modeling

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Motion capture, MR scan, CT scan

All volunteers will go through the same data collection process

Group Type: OTHER

Motion capture

Intervention Type: OTHER

Capture kinematics of finger movements

MR scan

Intervention Type: DIAGNOSTIC_TEST

Capture MR images of hand and fingers in three postures

CT scan

Intervention Type: DIAGNOSTIC_TEST

Capture CT images of hand and fingers in three postures

Interventions

Motion capture

Capture kinematics of finger movements

Intervention Type: OTHER

MR scan

Capture MR images of hand and fingers in three postures

Intervention Type: DIAGNOSTIC_TEST

CT scan

Capture CT images of hand and fingers in three postures

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• In general good health
• University of Southampton members of staff
• Over 18 years old and able to provide informed consent
• No known problems relating to the PIP joint

Exclusion Criteria

• Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
• Those undergoing treatment related to the PIP joint
• No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Southampton

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Christopher WG Phillips, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Southampton

Locations

University Hospital Southampton

Southampton, Hampshire, United Kingdom

Countries

United Kingdom

References

Adams J, Ryall C, Pandyan A, Metcalf C, Stokes M, Bradley S, Warwick DJ. Proximal interphalangeal joint replacement in patients with arthritis of the hand: a meta-analysis. J Bone Joint Surg Br. 2012 Oct;94(10):1305-12. doi: 10.1302/0301-620X.94B10.29035.

Reference Type: BACKGROUND

PMID: 23015553 (View on PubMed)

Other Identifiers

PUNI1713

Identifier Type: -

Identifier Source: org_study_id