Impact of a Hospital Pharmacist's Intervention on FENO (Fractional Exhaled Nitric Oxide) in Asthmatic Patients

NCT ID: NCT03093363

Last Updated: 2017-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2017-04-30

Brief Summary

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The impact of a pharmacist's intervention on asthma control has now been well demonstrated, but its effect on inflammatory markers of FENO (Fractional exhaled nitric oxide) in asthmatic patients has been little studied in the literature. The aim of this study is to investigate the impact of a pharmacist's intervention on FENO in patients seen in clinical practice by a pneumologist in a secondary university center.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Study Groups

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Intervention group

Asthmatic patients with the pharmacist's intervention

Group Type OTHER

Pharmacist's intervention

Intervention Type OTHER

Pharmacist's intervention with asthmatic patients:

* Detailed questionnaire on asthma and treatments (atopy, comorbidities, smoking status, asthma control, adverse effects of treatments, etc.)
* Explanation of asthma and inflammation
* Explanation of triggers and how to avoid it
* Explanation of asthma treatments
* Explanation of the inhalation technique with a physical demonstration
* Emphasis on treatment adherence
* Assessment of comorbidities and their treatment
* Emphasis on influenza vaccination

Control group

Asthmatic patients without the pharmacist's intervention (only questionnaires)

Group Type OTHER

Questionnaires for control group

Intervention Type OTHER

\- Detailed questionnaire on asthma and treatments (atopy, comorbidities, smoking status, asthma control, adverse effects of treatments, etc.)

Interventions

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Pharmacist's intervention

Pharmacist's intervention with asthmatic patients:

* Detailed questionnaire on asthma and treatments (atopy, comorbidities, smoking status, asthma control, adverse effects of treatments, etc.)
* Explanation of asthma and inflammation
* Explanation of triggers and how to avoid it
* Explanation of asthma treatments
* Explanation of the inhalation technique with a physical demonstration
* Emphasis on treatment adherence
* Assessment of comorbidities and their treatment
* Emphasis on influenza vaccination

Intervention Type OTHER

Questionnaires for control group

\- Detailed questionnaire on asthma and treatments (atopy, comorbidities, smoking status, asthma control, adverse effects of treatments, etc.)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult asthmatics (definition of asthma: FEV1 \[forced expiratory volume in 1 second\] reversibility of at least 12% and 200 mL after 400 mcg of salbutamol and/or PC20M \[provocative concentration of methacholine causing a 20% fall in FEV1\]\<16 mg/mL)
* unchanged or increased dose of inhaled corticosteroids prescribed by the pneumologist at the visit
* FENO (fractional exhaled nitric oxide) \> or = 25 ppb

Exclusion Criteria

* Treatment with oral corticosteroids to treat an asthma exacerbation within 4 weeks before the visit with the pneumologist


* Change of the dose of ICS (inhaled corticosteroids) during the follow-up of 3 months after the pharmacist's intervention
* Severe asthma exacerbation requiring oral corticosteroids within the 4 weeks before the follow-up visit (3 months after the pharmacist's intervention)
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Liege

OTHER

Sponsor Role lead

Responsible Party

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Renaud Louis

Professor, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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B707201629850

Identifier Type: -

Identifier Source: org_study_id