Study of the Relationship Between Blood Groups,RH and Skeletal Malocclusion : a Cross Sectional Study

NCT ID: NCT03085082

Last Updated: 2017-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-01

Study Completion Date

2017-12-31

Brief Summary

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the study is searching if there is a relationship between the blood groups and RH and the skeletal malocclusion using the skeletal class I as a control group

Detailed Description

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The study will be conducted on the patients seeking medical care in the orthodontic department Cairo University, for six months all patients with class II and class III malocclusion will be recruited based on Wits appraisal measured from the cephalometric X-ray taken routinely during orthodontic examination. Then a group of class I arch length discrepancy patients will be used as control. A blood sample will be withdrawn and taken to the Cairo university laboratory to analyze the blood group and RH .a statistical analysis will be performed to detect a relationship between skeletal malocclusion and the blood groups as compared to the control

Conditions

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Class II Malocclusion Class III Malocclusion

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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skeletal class II subjects

patients with wits appraisal more than 3 mm measured on a cephalometric x ray obtained during diagnosis

blood type test

Intervention Type DIAGNOSTIC_TEST

a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups

skeletal class III subjects

patients with wits appraisal less than -3 mm measured on a cephalometric x ray obtained during diagnosis

blood type test

Intervention Type DIAGNOSTIC_TEST

a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups

skeletal class I patients

patients with Wits appraisal between -3 and +3 that is measured from a cephalometric x ray obtained during diagnosis of arch length discrepancy. this group will serve as control and obtained after recruitment of the other 2 groups in 1 to 1 fashion

blood type test

Intervention Type DIAGNOSTIC_TEST

a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups

Interventions

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blood type test

a blood sample will be withdrawn from the subjects tested by anti A anti B and anti D antigens to detect the individuals blood group and RH. then statistical analysis to detect presence of a relationship between skeletal types of malocclusion and ABO blood groups

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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ABO and RH test blood typing

Eligibility Criteria

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Inclusion Criteria

skeletal class I,II and III patients non syndromic patients above the age of 18 no previous surgical intervention for correction of skeletal malocclusion

Exclusion Criteria

* syndromic patients
* cleft patients
* patients with previous surgery to correct skeletal malocclusion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Noor Elsebai Mohamed

Master student of the orthodontic program Cairo university

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amgad qaddah, professor

Role: STUDY_DIRECTOR

head of department of orthodontics cairo university

Central Contacts

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Noor Elsebai

Role: CONTACT

01023415842

References

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Flannery, P. M. (1969). Loyola eCommons The Abo Human Blood Groups and Skeletal Class IIi Malocclusions.

Reference Type BACKGROUND

Schnibben, C. L. (1968). Loyola eCommons A Study of the Relationships of the ABO Human Blood Groups , the Rh Factor and Hereditary Malocclusions of the Skeletal Type , Class II , Division 1.

Reference Type BACKGROUND

Gheisari R, Ghoreishian M, Movahedian B, Roozbehi A. The association between blood groups and maxillofacial deformities. Indian J Plast Surg. 2008 Jul;41(2):138-40. doi: 10.4103/0970-0358.44921.

Reference Type BACKGROUND
PMID: 19753252 (View on PubMed)

Science, D. (2015). International Journal of Pharma and Bio Sciences ISSN CRANIOFACIAL MORPHOLOGY WITH GENETIC INFLUENCE OF ABO BLOOD, 6(4), 412±418.

Reference Type BACKGROUND

Other Identifiers

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skeletal_malocclusion_ABO

Identifier Type: -

Identifier Source: org_study_id

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