Effect of High Protein, High-calorie Oral Nutritional Supplementation in Malnourished Elderly in Nursing Homes.

NCT ID: NCT03083912

Last Updated: 2017-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

291 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-31

Study Completion Date

2017-10-31

Brief Summary

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The hypothesis of this study is that the administration of a high-calorie high-protein oral nutritional supplement twice a day for three months to elderly malnourished in residents in Spain is associated with improved nutritional status, with an increase in body weight of between 5 and 8%, and an improvement in functional status, with low incidence of complication.

Detailed Description

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A prospective, multi centric, observational study. The study is conducted in elderly living in nursing homes in Spain.

Conditions

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Other Malnutrition

Keywords

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Malnutrition Disability Oral Nutritional Supplementation

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Fortimel Complete

All of the residents included receive ONS

Fortimel Complete

Intervention Type DIETARY_SUPPLEMENT

The residents included receive 2 bottle por day.

Interventions

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Fortimel Complete

The residents included receive 2 bottle por day.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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ONS

Eligibility Criteria

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Inclusion Criteria

* Age greater than or equal to 65 years,
* Living in nursing homes,
* Malnutrition treated with an hyper-caloric oral nutritional supplementation (1.3 Kcal / ml) and high-protein (protein 20%).

Exclusion Criteria

* Tube feeding (nasogastric or gastrostomy)
* Terminally ill or palliative treatment and residents with life expectancy of less than 6 months
* Special nutritional requirements (for example by intestinal malabsorption, short bowel residents or specific nutrition for renal insufficiency).
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Universitario Ramon y Cajal

OTHER

Sponsor Role collaborator

Hospital General Universitario Gregorio Marañon

OTHER

Sponsor Role collaborator

Hospital Clinic of Barcelona

OTHER

Sponsor Role collaborator

Hospital Viamed Valvanera, Spain

OTHER

Sponsor Role lead

Responsible Party

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Vincenzo Malafarina, MD MSc

MD, MSc, PhD3

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nuria Fernandez Bodas

Role: STUDY_CHAIR

Nutricia, Inc.

Alfonso Cruz Jentoft, MD PhD

Role: STUDY_DIRECTOR

Head of Geriatric Department, Hospital Universitario Ramón y Cajal

Locations

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Hospital Universitario Ramón y Cajal

Madrid, , Spain

Site Status

Countries

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Spain

References

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Malafarina V, Uriz-Otano F, Gil-Guerrero L, Iniesta R. The anorexia of ageing: physiopathology, prevalence, associated comorbidity and mortality. A systematic review. Maturitas. 2013 Apr;74(4):293-302. doi: 10.1016/j.maturitas.2013.01.016. Epub 2013 Feb 13.

Reference Type BACKGROUND
PMID: 23415063 (View on PubMed)

van Nie-Visser NC, Meijers J, Schols J, Lohrmann C, Bartholomeyczik S, Spreeuwenberg M, Halfens R. Which characteristics of nursing home residents influence differences in malnutrition prevalence? An international comparison of The Netherlands, Germany and Austria. Br J Nutr. 2014 Mar 28;111(6):1129-36. doi: 10.1017/S0007114513003541. Epub 2013 Nov 18.

Reference Type BACKGROUND
PMID: 24246053 (View on PubMed)

Salva A, Serra-Rexach JA, Artaza I, Formiga F, Rojano I Luque X, Cuesta F, Lopez-Soto A, Masanes F, Ruiz D, Cruz-Jentoft AJ. [Prevalence of sarcopenia in Spanish nursing homes: Comparison of the results of the ELLI study with other populations]. Rev Esp Geriatr Gerontol. 2016 Sep-Oct;51(5):260-4. doi: 10.1016/j.regg.2016.02.004. Epub 2016 Apr 9. Spanish.

Reference Type BACKGROUND
PMID: 27068239 (View on PubMed)

Camina-Martin MA, de Mateo-Silleras B, Malafarina V, Lopez-Mongil R, Nino-Martin V, Lopez-Trigo JA, Redondo-del-Rio MP. Nutritional status assessment in geriatrics: Consensus declaration by the Spanish Society of Geriatrics and Gerontology Nutrition Work Group. Maturitas. 2015 Jul;81(3):414-9. doi: 10.1016/j.maturitas.2015.04.018. Epub 2015 May 14.

Reference Type BACKGROUND
PMID: 26025067 (View on PubMed)

Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review. J Am Med Dir Assoc. 2013 Jan;14(1):10-7. doi: 10.1016/j.jamda.2012.08.001. Epub 2012 Sep 13.

Reference Type BACKGROUND
PMID: 22980996 (View on PubMed)

Lozano-Montoya I, Velez-Diaz-Pallares M, Abraha I, Cherubini A, Soiza RL, O'Mahony D, Montero-Errasquin B, Correa-Perez A, Cruz-Jentoft AJ. Nonpharmacologic Interventions to Prevent Pressure Ulcers in Older Patients: An Overview of Systematic Reviews (The Software ENgine for the Assessment and optimization of drug and non-drug Therapy in Older peRsons [SENATOR] Definition of Optimal Evidence-Based Non-drug Therapies in Older People [ONTOP] Series). J Am Med Dir Assoc. 2016 Apr 1;17(4):370.e1-10. doi: 10.1016/j.jamda.2015.12.091. Epub 2016 Feb 5.

Reference Type BACKGROUND
PMID: 26857298 (View on PubMed)

Other Identifiers

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PROT-e-GER

Identifier Type: -

Identifier Source: org_study_id