Endosseous Oroantral Port for Minimal Intervention in Treating Chronic Sinusitis

NCT ID: NCT03083392

Last Updated: 2017-03-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-31

Study Completion Date

2019-03-31

Brief Summary

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This study is intended to evaluate the efficiency of utilizing "dynamic implant valve approach" (DIVA) system in treating chronic maxillary sinusitis.

Detailed Description

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A prospective study aimed to test the efficiency of a minimal interventional approach in treating chronic maxillary sinusitis. The "dynamic implant valve approach" (DIVA), a minimally invasive approach utilizes a dental implant, designed with an internal sealing screw that might serve as drug delivery system via its channel. The implant is inserted to a posterior maxillary edentulous area, creating a connection between the sinus cavity and the oral cavity (Oro-antral connection), hence, provides a controlled working channel for diagnosis and treatment of the disease (e.g; allowing drainage, lavage and sinus endoscopy). The implant is a medical device approved for use at the anatomical area of interest.

The treatment method proposed in this study is based on the principle of a conventional treatment of washing the maxillary sinus cavity called "Antral puncture and lavage".

The changes that are proposed in this study could make the operation more convenient and effective in the therapeutic level, both for the patient and the clinician for the following reasons:

* DIVA (Dynamic Implant Valve Approach) Implant with a multi- useful working channel: the mere presence of the canal in the center of the implant with a screw seal, ensures controlled Oro-antral connection, and enables multiple endoscopy and lavage procedures until resolution of the pathological condition is achieved.
* The anatomical location of the puncture / penetration to the sinus - is performed in the maxillary edentulous region. This is the lowest area of the sinus cavity (standing or sitting posture), which utilizes gravity for drainage and extraction of the contaminated contents of the sinus.

By appropriate advance planning, the implant, after eradication of the disease, can later be used for prosthetic purposes.

Conditions

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Maxillary Sinusitis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment

treatment of chronic maxillary sinusitis using DIVA system

Group Type EXPERIMENTAL

treatment of chronic maxillary sinusitis using DIVA system

Intervention Type PROCEDURE

chronic maxillary sinusitis treatment utilizing DIVA system for antral lavage

"dynamic implant valve approach" - DIVA system

Intervention Type DEVICE

The DIVA system will be used to apply saline lavage to the maxillary sinus

Interventions

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treatment of chronic maxillary sinusitis using DIVA system

chronic maxillary sinusitis treatment utilizing DIVA system for antral lavage

Intervention Type PROCEDURE

"dynamic implant valve approach" - DIVA system

The DIVA system will be used to apply saline lavage to the maxillary sinus

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* No medical history of diseases involving bone metabolism
* Unilateral or bilateral maxillary sinusitis, as evident by radiographic and endoscopic modaleties, which have not responded to optimal conservative treatment
* Patient who is edentulous in the maxillary region and is interested in dental implant
* The patient does not participate in another clinical study
* The patient can read and understand the informed consent

Exclusion Criteria

* Medical history of increased risk of developing bone necrosis (MRONJ - medically related osteonecrosis of the jaw , or ORN - osteoradionecrosis)
* patients who are not interested or need dental implants
* Patients with maxillary sinus neoplastic pathology
* Chronic maxillary sinusitis with polyps
* Pregnant women
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Western Galilee Hospital-Nahariya

OTHER_GOV

Sponsor Role lead

Responsible Party

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ruth angel dar

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Samer Srouji, Prof.

Role: STUDY_DIRECTOR

Western Galilee Medical Center

Locations

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Western Galilee Medical Center

Nahariya, , Israel

Site Status

Countries

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Israel

Central Contacts

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Ruth Angel-Dar, Dr.

Role: CONTACT

+972-4-9107076

Samer Srouji, Prof.

Role: CONTACT

+972-4-9107270

Facility Contacts

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Sigal Shor

Role: primary

+972-4-9107270

References

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Albu S, Baciut M, Opincariu I, Rotaru H, Dinu C. The canine fossa puncture technique in chronic odontogenic maxillary sinusitis. Am J Rhinol Allergy. 2011 Sep-Oct;25(5):358-62. doi: 10.2500/ajra.2011.25.3673.

Reference Type BACKGROUND
PMID: 22186252 (View on PubMed)

Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang de Y, Wormald PJ. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012 Mar;50(1):1-12. doi: 10.4193/Rhino12.000.

Reference Type BACKGROUND
PMID: 22469599 (View on PubMed)

Ludlow JB, Ivanovic M. Comparative dosimetry of dental CBCT devices and 64-slice CT for oral and maxillofacial radiology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):106-14. doi: 10.1016/j.tripleo.2008.03.018. Epub 2008 May 27.

Reference Type BACKGROUND
PMID: 18504152 (View on PubMed)

Nahlieli O, Moshonov J, Zagury A, Michaeli E, Casap N. Endoscopic approach to dental implantology. J Oral Maxillofac Surg. 2011 Jan;69(1):186-91. doi: 10.1016/j.joms.2010.07.071. Epub 2010 Nov 2.

Reference Type BACKGROUND
PMID: 21050639 (View on PubMed)

Nahlieli O, Casap N, Moshonov J, Zagury A, Michali E, Samuni Y. A novel dental implant system with an internal port for endoscopic closed sinus augmentation: a feasibility study in pigs. Int J Oral Maxillofac Implants. 2013 Nov-Dec;28(6):e556-61. doi: 10.11607/jomi.te36.

Reference Type BACKGROUND
PMID: 24278950 (View on PubMed)

Neugebauer J, Ritter L, Mischkowski RA, Dreiseidler T, Scherer P, Ketterle M, Rothamel D, Zoller JE. Evaluation of maxillary sinus anatomy by cone-beam CT prior to sinus floor elevation. Int J Oral Maxillofac Implants. 2010 Mar-Apr;25(2):258-65.

Reference Type BACKGROUND
PMID: 20369083 (View on PubMed)

Rosenfeld RM, Andes D, Bhattacharyya N, Cheung D, Eisenberg S, Ganiats TG, Gelzer A, Hamilos D, Haydon RC 3rd, Hudgins PA, Jones S, Krouse HJ, Lee LH, Mahoney MC, Marple BF, Mitchell CJ, Nathan R, Shiffman RN, Smith TL, Witsell DL. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007 Sep;137(3 Suppl):S1-31. doi: 10.1016/j.otohns.2007.06.726.

Reference Type BACKGROUND
PMID: 17761281 (View on PubMed)

Other Identifiers

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0015-17-NHR

Identifier Type: -

Identifier Source: org_study_id

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