The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis

NCT ID: NCT03080740

Last Updated: 2017-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2017-12-31

Brief Summary

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Randomized, double blind, positive drug parallel comparison, multi-centre clinical trial to assess the Efficacy and Safety of Clindamycin palmitate hydrochloride dispersible tablet for the treatment of bacterial vaginosis

Detailed Description

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Treatment group: Clindamycin palmitate hydrochloride dispersible tablet . Control group: Metronidazole Tablet.

Conditions

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Bacterial Vaginosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Clindamycin palmitate hydrochloride

Clindamycin palmitate hydrochloride dispersible tablet 300mg, oral after meal, twice daily, a total of 7days

Group Type ACTIVE_COMPARATOR

Clindamycin palmitate hydrochloride dispersible tablet

Intervention Type DRUG

300mg, oral after meal, twice daily, a total of 7days

Metronidazole

Metronidazole Tablet 400mg, oral after meal , twice daily, a total of 7days

Group Type ACTIVE_COMPARATOR

Metronidazole Tablet

Intervention Type DRUG

400mg, oral after meal , twice daily, a total of 7days

Interventions

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Clindamycin palmitate hydrochloride dispersible tablet

300mg, oral after meal, twice daily, a total of 7days

Intervention Type DRUG

Metronidazole Tablet

400mg, oral after meal , twice daily, a total of 7days

Intervention Type DRUG

Other Intervention Names

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No other Names No other Names

Eligibility Criteria

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Inclusion Criteria

1. Patients clinically diagnosed with bacterial vaginosis, should meet the following criteria: vaginal Gram stain integration score (Nugent score) ≥7 points
2. Female patients aged 18 to 55 years old.
3. Patients signed the Informed Consent Form(ICF).

Exclusion Criteria

1. Patients with vulvovaginitis caused by other infectional reasons such as vaginitis vulvovaginal candidiasis, trichomoniasis vaginitis.
2. Patients received systemic or vaginal antimicrobial therapy in a week before enrolled.
3. Patients with other vaginal or vulvar disorders which could effect the evaluation of efficacy.
4. Pregnant or lactating patients.
5. Menopausal women.

Menopause definition: perimenopausal women stop menstruations for a year.
6. Women with diabetes.
7. Dependent on alcohol and could not prohibit during the study period.
8. Women with liver and kidney disfunction, blood disorders, mental illness or other serious diseases.
9. Women allergic to metronidazole, clindamycin.
10. With poor compliance.
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Guangzhou Yipinhong Pharmaceutical CO.,LTD

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zhaohui Liu, MD

Role: STUDY_CHAIR

Peking University First Hospital

Shangrong Fan, MD

Role: PRINCIPAL_INVESTIGATOR

Peking University Shenzhen Hospital

Long Sui, MD

Role: PRINCIPAL_INVESTIGATOR

Affiliated Gynecology and Obstetrics Hospital of Fudan University

Ruifang An, MD

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital of Xi 'an Jiaotong University

Locations

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Peking University first hospital

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zhaohui Liu, MD

Role: CONTACT

+86-10-66174284

Dai Zhang, MD

Role: CONTACT

+86-10-66174284

Facility Contacts

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Zhaohui Liu, MD

Role: primary

+86-10-66174284

Other Identifiers

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YPH-BV

Identifier Type: -

Identifier Source: org_study_id

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