Trial Outcomes & Findings for The Pharmacist Follows You and Your Medication From Hospital to Your Daily Life and Investigate What This Means to You (NCT NCT03079375)

NCT ID: NCT03079375

Last Updated: 2019-12-02

Results Overview

number of patients who have been readmitted

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 1499 participants
• Primary outcome timeframe: 30 days
• Results posted on: 2019-12-02

Participant Flow

Participant milestones

Measure	Usual Care no pharmaceutical intervention.	Basic Intervention Medication review basic intervention: medication review	Extended Intervention medication review, medication interview before discharge and follow-up with patient, general practitioner and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Overall Study STARTED	503	499	497
Overall Study COMPLETED	498	493	476
Overall Study NOT COMPLETED	5	6	21

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up	Total n=1467 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=498 Participants	0 Participants n=493 Participants	0 Participants n=476 Participants	0 Participants n=1467 Participants
Age, Categorical Between 18 and 65 years	121 Participants n=498 Participants	141 Participants n=493 Participants	130 Participants n=476 Participants	392 Participants n=1467 Participants
Age, Categorical >=65 years	377 Participants n=498 Participants	352 Participants n=493 Participants	346 Participants n=476 Participants	1075 Participants n=1467 Participants
Age, Continuous	73 years n=498 Participants	72 years n=493 Participants	71 years n=476 Participants	72 years n=1467 Participants
Sex: Female, Male Female	278 Participants n=498 Participants	248 Participants n=493 Participants	262 Participants n=476 Participants	788 Participants n=1467 Participants
Sex: Female, Male Male	220 Participants n=498 Participants	245 Participants n=493 Participants	214 Participants n=476 Participants	679 Participants n=1467 Participants
Race and Ethnicity Not Collected	—	—	—	0 Participants Race and Ethnicity were not collected from any participant.

PRIMARY outcome

Timeframe: 30 days

number of patients who have been readmitted

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Readmissions	111 Participants	98 Participants	68 Participants

PRIMARY outcome

Timeframe: 180 days

number of patients who have been admitted

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Admissions	243 Participants	233 Participants	189 Participants

PRIMARY outcome

Timeframe: 180 days

number of patients who have emergency department visits

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Emergency Department Visits	21 Participants	19 Participants	15 Participants

PRIMARY outcome

Timeframe: 180 days

number of patients who experience primary composite endpoint, admissions or emergency department visits within 6 month

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Composite Endpoint, Admissions or Emergency Department Visits	243 Participants	233 Participants	193 Participants

SECONDARY outcome

Timeframe: 180 days after the inclusion date

number of patients who have drug related admissions

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Drug-related Admissions	96 Participants	95 Participants	75 Participants

SECONDARY outcome

Timeframe: 30 days after the inclusion date

number of patients who have drug related readmissions

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Drug-related Readmissions	38 Participants	34 Participants	24 Participants

SECONDARY outcome

Timeframe: up to 180 days

Population: Medication review data were not collected from the Usual care Group and were collected only for the Basic and Extended Groups. No interventions were sent to the general practitioner for the Usual care and the Basic intervention Groups.

Acceptance rate in primary care (general practitioner). Medication review data were not collected from the Usual care Group and were collected only for the Basic and Extended Groups.

Outcome measures

Measure	Usual Care n=476 Participants no pharmaceutical intervention.	Basic Intervention Medication review basic intervention: medication review	Extended Intervention medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Percentage of Medication Changes Accepted by GPs	66 percentage of medication changes	—	—

SECONDARY outcome

Timeframe: 1 month

Population: Medication review data were not collected from the Usual care Group and were collected only for the Basic and Extended Groups. The acceptance rate is only analyzed for of the basic intervention and the extended intervention in total.

Medication review data were not collected from the Usual care Group and were collected only for the Basic and Extended Groups.

Outcome measures

Measure	Usual Care n=493 Participants no pharmaceutical intervention.	Basic Intervention n=476 Participants Medication review basic intervention: medication review	Extended Intervention medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Medication Review Changes Accepted by Physicians (in Hospital)	61 percentage of medication changes	61 percentage of medication changes	—

SECONDARY outcome

Timeframe: 180 days after the inclusion date

number of patient who died within 6 month after inclusion

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Mortality	50 Participants	42 Participants	54 Participants

SECONDARY outcome

Timeframe: 180 days after the inclusion date

number of patients who have drug related death

Outcome measures

Measure	Usual Care n=498 Participants no pharmaceutical intervention.	Basic Intervention n=493 Participants Medication review basic intervention: medication review	Extended Intervention n=476 Participants medication review, medication interview before discharge and follow-up with patient, GP and if relevant pharmacy and nursing home. extended intervention: medication review, medication interview before discharge and follow-up
Drug Related Mortality	6 Participants	3 Participants	5 Participants

Adverse Events

Usual Care

Serious events: 0 serious events

Other events: 0 other events

Deaths: 50 deaths

Basic Intervention

Serious events: 0 serious events

Other events: 0 other events

Deaths: 42 deaths

Extended Intervention

Serious events: 0 serious events

Other events: 0 other events

Deaths: 54 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Lene V. Ravn-Nielsen clinical pharmacist

OdenseUH

Phone: +4523467925

Email: lene.ravn-nielsen@rsyd.dk

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place