Study Results
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View full resultsBasic Information
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COMPLETED
NA
23 participants
INTERVENTIONAL
2016-11-09
2017-10-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Intervention: INSPireD
This 5-8 session group intervention, "Integrating Nuanced Support for Perinatal adherence and Depression", aimed to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women. Intervention content was based on two established cognitive-behavioral interventions: problem-solving therapy and Cognitive Behavioral Therapy for Adherence and Depression.
Integrating Nuanced Support for Perinatal adherence and Depression
A 5-8 session intervention to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women
Treatment-as-usual + abbreviated intervention
This group received treatment-as usual, plus the option of completing an abbreviated version of the intervention (one session of problem-solving related to adherence and mental health) at the conclusion of study.
Integrating Nuanced Support for Perinatal adherence and Depression
A 5-8 session intervention to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women
Interventions
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Integrating Nuanced Support for Perinatal adherence and Depression
A 5-8 session intervention to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* HIV-infected and diagnosed with HIV during the index pregnancy
* Meet criteria for a major depressive episode
* Currently on antiretroviral therapy
* Receiving antenatal care at PMMH Gateway clinic
* Primary language English or isiZulu
* Access to a phone and willing to give researchers permission to reach them via phone
* Resident of Umlazi
Exclusion Criteria
* Active untreated, major mental illness (untreated psychosis, bipolar disorder, dementia, or active suicidality) that would interfere with study participation
* Less than 18 years of age
18 Years
45 Years
FEMALE
No
Sponsors
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Match Research
OTHER
National Institute of Mental Health (NIMH)
NIH
Massachusetts General Hospital
OTHER
Responsible Party
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Christina Psaros
Assistant Professor of Psychology
Principal Investigators
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Christina Psaros, PhD
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
MatCH Research
Durban, , South Africa
Countries
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References
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Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, Wilson IB. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008 Jan;12(1):86-94. doi: 10.1007/s10461-007-9261-4. Epub 2007 Jun 19.
Psaros C, Stanton AM, Raggio GA, Mosery N, Goodman GR, Briggs ES, Williams M, Bangsberg D, Smit J, Safren SA. Optimizing PMTCT Adherence by Treating Depression in Perinatal Women with HIV in South Africa: A Pilot Randomized Controlled Trial. Int J Behav Med. 2023 Feb;30(1):62-76. doi: 10.1007/s12529-022-10071-z. Epub 2022 Mar 8.
Choi KW, Smit JA, Coleman JN, Mosery N, Bangsberg DR, Safren SA, Psaros C. Mapping a Syndemic of Psychosocial Risks During Pregnancy Using Network Analysis. Int J Behav Med. 2019 Apr;26(2):207-216. doi: 10.1007/s12529-019-09774-7.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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2016P001887
Identifier Type: -
Identifier Source: org_study_id