Optimal Extent of Pulmonary Resection in Clinical Stage IA Non-Small Cell Lung Cancer
NCT ID: NCT03066297
Last Updated: 2023-12-06
Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
1018 participants
OBSERVATIONAL
2017-02-15
2027-02-15
Brief Summary
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The purpose of this study is to determine the outcome of participants with clinical stage IA NSCLC treated by 3 types of surgical resection (wide wedge resection, segmentectomy, or lobectomy) according to the institutional decision-making algorithm
The investigators are planning to enroll 1,000 participants who meet the pre-defined eligibility criteria over 5 years.
Detailed Description
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* The standard extent of pulmonary resection for non-small cell lung cancer (NSCLC) is still lobectomy. However, recent advances in imaging technology and staging modalities and the widespread use of computed tomography (CT) screening have greatly increased the probability of detecting small-sized tumors, especially with ground-glass opacity (GGO) feature. Adenocarcinoma with GGO feature generally has a good prognosis due to its minimally invasive nature. Many studies have shown that these pathologically less invasive subtypes are associated with better prognoses compared with other subtypes such as acinar, papillary, micropapillary, and solid predominant invasive adenocarcinoma.
* This recent change in the disease pattern of NSCLC from locally advanced and solid tumors to early and less invasive tumors with GGO features have led to a resurgence of interest in sublobar resection. Several retrospective studies have been conducted to compare the early and late outcomes including long-term survival between patients who underwent lobectomy and those who underwent sublobar resection.
* Multiple reports have suggested that small-sized peripheral lung adenocarcinoma can be treated by sublobar resection, yielding survival rates similar to those of lobectomy. Lobectomy is considered to be too much for these less invasive tumors and sublobar resection would be sufficient for these tumors. If sublobar resection is equivalent to lobectomy in terms of their oncologic efficacy for the surgical treatment of NSCLC, the potential benefits of sublobar resection include (1) the preservation of vital lung parenchyma and pulmonary function, which may lead to improved early morbidities and mortalities and then late quality of life and (2) a chance for a second resection with a subsequent primary NSCLC.
* However, when considering the published evidence for sublobar resection, its interpretation needs to be cautious. Since most studies were non-randomized, there may also have been selection bias in terms of preoperative patient risk factors (intentional vs. compromised sublobar resection), tumors of various histological subtypes or different tumor size in the study arms. Therefore, the results from two randomized trials of lobectomy versus sublobar resection for small-sized lung cancer currently ongoing in Japan (Japan Clinical Oncology Group \[0802\]) and in the United States (Cancer and Leukemia Group B \[140503\]) need to be awaited.
* Based on these clinical circumstances and the published evidence, the investigators developed the decision-making algorithm regarding the surgical treatment for clinical stage IA NSCLC.
2. Hypothesis The investigators hypothesized that selection of surgical procedure according to the pre-defined institutional decision-making algorithm will not compromise the treatment outcomes including overall survival and disease-free survival in patients with clinical stage IA non-small cell lung cancer.
3. Purpose The purpose of this study is to determine the outcome of participants with clinical stage IA NSCLC treated by 3 types of surgical resection (wide wedge resection, segmentectomy, or lobectomy) according to the institutional decision-making algorithm
4. Study plan The investigators are planning to enroll 1,000 participants who meet the pre-defined eligibility criteria over 5 years.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Lobectomy
Lobectomy will be chosen as the extent of pulmonary resection according to the institutional decision-making algorithm
No interventions assigned to this group
Segmentectomy
Segmentectomy will be chosen as the extent of pulmonary resection according to the institutional decision-making algorithm
Extent of pulmonary resection
Extent of pulmonary resection selected based on the institutional decision-making algorithm
Wide wedge resection
Wide wedge resection will be chosen as the extent of pulmonary resection according to the institutional decision-making algorithm
Extent of pulmonary resection
Extent of pulmonary resection selected based on the institutional decision-making algorithm
Interventions
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Extent of pulmonary resection
Extent of pulmonary resection selected based on the institutional decision-making algorithm
Eligibility Criteria
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Inclusion Criteria
* Solitary lung nodule
* Lesion size is 3cm or less in its maximal dimension of the entire tumor
* The center of the tumor is located in the outer third of the lung field in either the transverse, coronal, or sagittal plane
* Lung cancer is suspected (or NSCLC if tissue diagnosis already obtained)
2. Clinical stage T1a-bN0M0 (according to 7th AJCC staging system)
3. Absence of proximal segmental or lobar bronchial involvement.
4. NSCLC must be confirmed in intraoperative frozen section biopsies or postoperative pathologic examinations if the lesion was not histologically confirmed before operation.
5. Age ≥ 18 years and \< 75 years.
6. ECOG performance status 0-1.
7. The patient should have adequate cardiopulmonary reserve to tolerate lobectomy (ppo FEV1 \> 40% and ppo DLCO \> 40% or VO2 max \> 15ml kg-1 min-1)
8. No prior chemotherapy or thoracic radiotherapy for any malignancy.
9. No prior malignancy within 5 years from study entry (except for non-melanoma skin cancer, superficial bladder cancer, thyroid cancer or carcinoma in situ of the uterine cervix).
10. The patient agrees to participate in the study and signs the informed consent form.
Exclusion Criteria
2. Hilar or mediastinal lymph node metastasis suspected on imaging studies (CT or PET/CT) or confirmed preoperatively by EBUS or mediastinoscopy.
3. Parietal pleura, chest wall, or mediastinal invasion is confirmed intraoperatively or postoperatively.
4. M1a disease is confirmed intraoperatively or postoperatively.
5. Bilobectomy, sleeve resection, pneumonectomy, concomitant wedge resection, or concomitant thoracic procedure (including cardiac surgery) is performed.
6. Synchronous or metachronous multiple cancers (within the past 5 years).
7. Interstitial lung disease or severe pulmonary emphysema which makes it impossible to tolerate either lobectomy or sublobar resection.
8. Active bacterial or fungal infection.
9. Uncontrolled systemic disease which makes the patient medically unfit for thoracic surgery such as unstable angina, recent myocardial infarction, congestive heart failure, or end-stage renal or liver disease.
10. Serious mental illness or psychosis.
18 Years
75 Years
ALL
No
Sponsors
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Samsung Medical Center
OTHER
Responsible Party
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Hong Kwan Kim
MD, PhD, Department of Thoracic and Cardiovascular Surgery
Principal Investigators
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Hong Kwan Kim, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Samsung Medical Center
Locations
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Samsung Medical Center
Seoul, , South Korea
Countries
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Other Identifiers
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2016-12-116
Identifier Type: -
Identifier Source: org_study_id