Study of Doxorubicin in Patients With Metastatic Breast Cancer/Advanced Ovarian Cancer

NCT ID: NCT03055143

Last Updated: 2021-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-03

Study Completion Date

2009-11-28

Brief Summary

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This was a randomized, multi centre, open label, two treatment, two period, two sequence, single dose, crossover study, with at least 28 days washout between doses, conducted under fed (normal breakfast) conditions.

Detailed Description

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Conditions

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Breast Cancer and Ovarian Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Study Groups

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SPARC-08-038

2 mg/ml

Group Type EXPERIMENTAL

SPARC-08-038

Intervention Type DRUG

2 mg/ml intravenous infusion

Ref-08-038

Intervention Type DRUG

2 mg/ml intravenous infusion

Ref-08-038

Group Type ACTIVE_COMPARATOR

SPARC-08-038

Intervention Type DRUG

2 mg/ml intravenous infusion

Ref-08-038

Intervention Type DRUG

2 mg/ml intravenous infusion

Interventions

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SPARC-08-038

2 mg/ml intravenous infusion

Intervention Type DRUG

Ref-08-038

2 mg/ml intravenous infusion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Availability of volunteer for the entire study period and willingness to adhere to protocol requirements as evidenced by written informed consent.
2. Patients with metastatic breast cancer/advanced ovarian cancer having age within the range of between 18-55 years.
3. Subjects who had no evidence of underlying disease
4. Subjects who had signed written consent form

Exclusion Criteria

1. Females who were pregnant, breastfeeding, or are likely to become pregnant
2. Subjects who had any medical condition (except metastatic breast cancer/advanced ovarian cancer) that could jeopardize their health or prejudice the results
3. Subjects deemed uncooperative or noncompliant
4. Smoking or consumption of any nicotine products
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Sun Pharma Advanced Research Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Bhowmik S, Bhowmick S, Maiti K, Chakra A, Shahi P, Jain D, Rajamannar T. Two multicenter Phase I randomized trials to compare the bioequivalence and safety of a generic doxorubicin hydrochloride liposome injection with Doxil(R) or Caelyx(R) in advanced ovarian cancer. Cancer Chemother Pharmacol. 2018 Sep;82(3):521-532. doi: 10.1007/s00280-018-3643-3. Epub 2018 Jul 11.

Reference Type DERIVED
PMID: 29995186 (View on PubMed)

Other Identifiers

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PKD/08/038

Identifier Type: -

Identifier Source: org_study_id

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