Inflammatory Biomarkers and Brain Metabolites, a Study Based on Magnetic Resonance Spectroscopy
NCT ID: NCT03052855
Last Updated: 2021-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
69 participants
INTERVENTIONAL
2017-02-01
2017-11-29
Brief Summary
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Evidence associated dysregulation of the serotonergic system and the hypothalamic-pituitary-adrenal axis to vulnerability to SB. Recent data point to linke these abnormalities with neuroinflammatory clues, glutamatergic function and neuronal plasticity. There is a need to better understand the physiopathology and develop diagnostic and therapeutic tools in SB.
The investigators hypothesize that increased peripheral biomarkers of inflammation would correlate to a disturbance of the cerebral metabolites, such as glutamate and NAA, especially in suicidal patients.
Our aim is to compare rates of cerebral metabolites, in particular the complex glutamine/glutamate, in cerebral areas involved in suicidal vulnerability (the anterior cingulate cortex and the orbito-frontal cortex) between person with unipolar disorder with and without suicidal attempt.
Detailed Description
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2 visits :
* Inclusion visit (V0) : (Day 1)
o Clinical interview : self and hetero assessment questionnaire
* Visit V1 (as soon as possible, day 1 if available) :
* MRI (spectroscopy)
Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Participants
All the participants of the 3 groups (depressed patients with suicide attempt, depressed patients without suicide attempt, healthy volunteers) will have to realize a MRI and biological samples.
Magnetic Resonance Imaging (MRI) and biological samples
Participants will have to do a MRI and biological samples.
Interventions
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Magnetic Resonance Imaging (MRI) and biological samples
Participants will have to do a MRI and biological samples.
Eligibility Criteria
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Inclusion Criteria
* Able to understand nature, aims and methodology of the study
* Suicidal patient with suicide attempt :
* Persistent depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders - V (DSM-V) criteria, and evaluated by the Mini International Neuropsychiatric Interview (MINI)
* Hamilton Depression Scale \> 7
* Suicide attempt \< 1 week
* Suicidal patient without suicide attempt :
* Persistent depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders - V (DSM-V) criteria, and evaluated by the Mini International Neuropsychiatric Interview (MINI)
* Hamilton Depression Scale \> 7
* No history of suicide attempt
* Healthy volunteers :
* No psychiatric history
* No history of suicide attempt
Exclusion Criteria
* Traumatic brain injury with loss of consciousness
* Antibiotic treatment or anti-inflammatory treatment
* Actual toxic abuse according to DSM-V (except tobacco and alcohol)
* Actual or passed history of psychotic disorder
* Patient on protective measures (guardianship or trusteeship)
* Deprived of liberty subject (judicial or administrative decision)
* Pregnant women or breastfeeding
* Contraindications to MRI scan
18 Years
70 Years
ALL
Yes
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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Frédéric COPPOLA, MD
Role: PRINCIPAL_INVESTIGATOR
Montpellier Hospital University
Locations
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Montpellier Hospital University
Montpellier, , France
Countries
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References
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Olie E, Clain G, Malestroit M, Fiedos D, Cognasse F, Deverdun J, Bars EL, Courtet P. Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder. J Clin Psychiatry. 2024 Jun 26;85(3):23m15148. doi: 10.4088/JCP.23m15148.
Other Identifiers
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2016-A01267-44
Identifier Type: OTHER
Identifier Source: secondary_id
UF9741
Identifier Type: -
Identifier Source: org_study_id