CKD-581 + Bortezomib + Dexamethasone in Patients With Previously Treated Multiple Myeloma

NCT ID: NCT03051841

Last Updated: 2020-02-24

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-01-31
• Study Completion Date: 2022-11-30

Brief Summary

This study is to determine the maximum tolerated dose(MTD), dose limiting toxicity(DLT), safety and pharmacokinetics(PK) profile of a single agent CKD-581 injection in Combination with Bortezomib and Dexamethasone in patients with Previously Treated Multiple Myeloma.

Detailed Description

This is an open label, dose escalation study. Cohort of 3~6 patients receive escalation doses of CKD-581 until the maximum toleated dose(MTD) is determined. The MTD is defiend as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose limiting toxicity.

Conditions

Myeloma, Multiple

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treat Regimen

CKD-581(investigational Drug) Bortezomib Dexamethasone

Group Type: EXPERIMENTAL

CKD-581

Intervention Type: DRUG

Intravenously on Days 1, 8 of each 21-day treatment cycle.

Interventions

CKD-581

Intravenously on Days 1, 8 of each 21-day treatment cycle.

Intervention Type: DRUG

Other Intervention Names

CKD-581 bortezomib dexamethasone regimen

Eligibility Criteria

Inclusion Criteria

• must have received at least one prior lines of therapy and Diagnosis of symptomatic multiple myeloma(IMWG 2014)
• Eastern Cooperative Oncology Group performance status ≤ 2
• Life expectancy 12 weeks
• must have the following laboratory values within 3 weeks prior to first dose of study drug

• ANC(absolute neutrophil count) ≥ 1,500 mm3
• PLT(platelet count)≥ 100,000 mm3
• Hb ≥ 8.0g/dL
• AST(SGOT) and ALT (SGPT) ≤ 3 x UNL(upper limit of normal)
• Serum bilirubin ≤ 1.5 x ULN (but, Gilbert syndrome ≤ 3 x UNL)
• Serum Cr ≤ 1.5 x UNL
• One more measureable disease following values

• Serum M-protein ≥ 1g/dL
• Urine M-Protein ≥ 200mg/24hr
• in that case serum M-protein, urine M-Protein nonmeasurable and FLC ratio abnormal, Serum FLC level ≥ 100mg/L(≥10mg/dL)
• more than 24 weeks prior to last bortezomib dose
• must have signed the consent form

Exclusion Criteria

• Patients with central neurological disease
• Patients with clinically significant heart disease within 24weeks prior to first dose of study drug
• patients with clinically significans abnormal EKG, echocardiography at screening
• patients with active hepatitis, HIV positive(exception, non active hepatitis)
• peripheral neuropathy ≥ CTCAE grade 2 or peripheral neuropathy ≥ CTCAE grade 1 with pain within 2 weeks prior to first dose of study drug
• Patients with a prior malignancy with in the last 3 years except adequately treated basal cell or squamous cell or skin cancer, in situ cervical cancer
• Patients who have received surgery, chemotherapy, radiation therapy or immunotherapy or any other investigational drugs ≤ 4 weeks prior to first dose of study drug and during treatment period
• Women who are pregnant or breast feeding or women of childbearing potential not using an effective method of birth control. Male patients whose sexual partners are not using effective birth control.
• patients with hypersensitive reaction of bortezomib or dexamethasone
• patients without best overall response is above minimal response based on IMWG 2015 past all treatment for multiple myeloma
• patients with refractory to past bortezomib treatment(ex; under minimal response) or progress within 60days prior to last bortezomib treatment

• Minimum Eligible Age: 19 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chong Kun Dang Pharmaceutical

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Min Ji Song

Role: STUDY_DIRECTOR

Chong Kun Dang Pharmaceutical Corp.

Locations

Seoul National University Hospital

Seoul, , South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Min Ji Song

Role: CONTACT

songmj@ckdpharm.com

+82-2-3149-7853

Facility Contacts

Sung-Soo Yoon

Role: primary

ssysmc@gmail.com

+82-2-2072-3079

Other Identifiers

133MM16010

Identifier Type: -

Identifier Source: org_study_id