University of Wisconsin Solution Versus New Parathyroid Transport Solution for Parathyroid Allotransplantation
NCT ID: NCT03051308
Last Updated: 2017-02-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
7 participants
INTERVENTIONAL
2017-03-01
2017-07-01
Brief Summary
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Detailed Description
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Cold ischemia protects organs and tissues by slowing their metabolism. The cold ischemia of the transplant tissue is a very important process. The University of Wisconsin (UW) solution substantially improves graft preservation and consequently increases patient survival. The researchers newly developed NPTS for transportation of parathyroid glands.
For the comparision the researchers measured the parathyroid cell viability and the calcium sensing and vitamin D receptor density of the parathyroid cells at the 0, 6, 12 and 24 hours of cold ischemia.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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First Application in Hour 0
Viability, Calcium-sensing receptor, Vitamin D receptor and parathormone levels of Parathyroid cells (10\^7 cells) at 'First Application in Hour 0' non-cold ischemia tissue group
NPT and UW Solution
Tissue preservation solutions for transplantation
First Application in Hour 6
Viability, Calcium-sensing receptor, Vitamin D receptor and parathormone levels of Parathyroid cells (10\^7 cells) at 'First Application in Hour 6' cold ischemic tissue group
NPT and UW Solution
Tissue preservation solutions for transplantation
First Application in Hour 12
Viability, Calcium-sensing receptor, Vitamin D receptor and parathormone levels of Parathyroid cells (10\^7 cells) at 'First Application in Hour 12' cold ischemic tissue group
NPT and UW Solution
Tissue preservation solutions for transplantation
First Application in Hour 18
Viability, Calcium-sensing receptor, Vitamin D receptor and parathormone levels of Parathyroid cells (10\^7 cells) at 'First Application in Hour 18' cold ischemic tissue group
NPT and UW Solution
Tissue preservation solutions for transplantation
First Application in Hour 24
Viability, Calcium-sensing receptor, Vitamin D receptor and parathormone levels of Parathyroid cells (10\^7 cells) at 'First Application in Hour' 24 cold ischemic tissue group
NPT and UW Solution
Tissue preservation solutions for transplantation
Interventions
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NPT and UW Solution
Tissue preservation solutions for transplantation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients younger than 18 years and older than 80 years.
* Patients who have hepatitis B,
* Patients who have hepatitis C,
* Patients who have human immunodeficiency virus (HIV).
18 Years
80 Years
ALL
No
Sponsors
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Bezmialem Vakif University
OTHER
SB Istanbul Education and Research Hospital
OTHER
Responsible Party
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Erhan Aysan
Principal Investigator
Principal Investigators
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Erhan Aysan, Prof. M.D.
Role: STUDY_DIRECTOR
Bezmialem Vakif University
Locations
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Bezmialem Vakif University Hospital
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Belzer FO, Southard JH. Principles of solid-organ preservation by cold storage. Transplantation. 1988 Apr;45(4):673-6. doi: 10.1097/00007890-198804000-00001. No abstract available.
Southard JH, van Gulik TM, Ametani MS, Vreugdenhil PK, Lindell SL, Pienaar BL, Belzer FO. Important components of the UW solution. Transplantation. 1990 Feb;49(2):251-7. doi: 10.1097/00007890-199002000-00004.
Guibert EE, Petrenko AY, Balaban CL, Somov AY, Rodriguez JV, Fuller BJ. Organ Preservation: Current Concepts and New Strategies for the Next Decade. Transfus Med Hemother. 2011;38(2):125-142. doi: 10.1159/000327033. Epub 2011 Mar 21.
Voigt MR, DeLario GT. Perspectives on abdominal organ preservation solutions: a comparative literature review. Prog Transplant. 2013 Dec;23(4):383-91. doi: 10.7182/pit2013100.
Other Identifiers
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BAVUvsUW
Identifier Type: -
Identifier Source: org_study_id
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