Magnesium Effect on Embryonal PR Interval

NCT ID: NCT03047304

Last Updated: 2017-02-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-14

Study Completion Date

2018-03-10

Brief Summary

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Magnesium is a known treatment for neuroprotection in preterm labor before 32 week of gestation. High concentration of Magnesium in the blood stream known as cause of conduction abnormalities and ECG changes such us prolonged QT, QRS and PR in about. The goal of our work is to evaluate the PR intervals in embryos after maternal treatment with magnesium during preterm labor.

Detailed Description

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We will recruit 25 woman with threaten preterm labor, magnesium blood level and PR interval will be evaluated before magnesium loading dose (4gr) and 20 minutes after the loading dose.

PR interval will be evaluated by Mitral-Aorta Doppler.

Conditions

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Preterm Labor

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Women in risk for preterm labor

Women in risk for preterm labor treated with magnesium.

Group Type OTHER

Trans abdominal sonography

Intervention Type DIAGNOSTIC_TEST

Trans abdominal sonography in order to measure fetal PR interval.

Interventions

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Trans abdominal sonography

Trans abdominal sonography in order to measure fetal PR interval.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Women at risk for preterm labor before 32 week of gestation

Exclusion Criteria

* Fetal malformations
* Maternal Lupus
* Fetal conduction abnormalities
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Ola Gutzeit MD

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ola Gutzeit, MD

Role: PRINCIPAL_INVESTIGATOR

Principal Investigator

Central Contacts

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Ola Gutzeit, MD

Role: CONTACT

972543088220

References

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Gums JG. Clinical significance of magnesium: a review. Drug Intell Clin Pharm. 1987 Mar;21(3):240-6. doi: 10.1177/106002808702100301.

Reference Type BACKGROUND
PMID: 3552543 (View on PubMed)

Agus ZS, Morad M. Modulation of cardiac ion channels by magnesium. Annu Rev Physiol. 1991;53:299-307. doi: 10.1146/annurev.ph.53.030191.001503. No abstract available.

Reference Type BACKGROUND
PMID: 1710436 (View on PubMed)

Laurant P, Touyz RM. Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. J Hypertens. 2000 Sep;18(9):1177-91. doi: 10.1097/00004872-200018090-00003.

Reference Type BACKGROUND
PMID: 10994748 (View on PubMed)

Glickstein JS, Buyon J, Friedman D. Pulsed Doppler echocardiographic assessment of the fetal PR interval. Am J Cardiol. 2000 Jul 15;86(2):236-9. doi: 10.1016/s0002-9149(00)00867-5. No abstract available.

Reference Type BACKGROUND
PMID: 10913494 (View on PubMed)

Other Identifiers

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0531-15-RMB

Identifier Type: -

Identifier Source: org_study_id

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