High Intensity Interval Training in Osteoarthritis, Effects on Metabolomics
NCT ID: NCT03039452
Last Updated: 2017-10-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2017-01-31
2017-10-31
Brief Summary
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Participants: Fifteen patients (age 40-70 yrs; BMI 20-35 kg/m²) with symptomatic knee OA
Procedures (methods): All participants will be assigned to the single-arm of the study in which all participants will receive 6 weeks of HIIT, delivered twice per week. Outcomes will be assessed at baseline and 6 weeks. The primary outcome will evaluate tolerability, feasibility, acceptability, compliance, and adherence to the HIIT program. Secondary outcomes will include whole body metabolism markers, inflammation, and a set of physical function including knee osteoarthritis symptomatic burden and pain, cardiorespiratory fitness, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), and body composition.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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High intensity interval training
High intensity interval training
Each training session will consist of a 3-5 minute warm-up, followed by 10 repetitions of 1-minute bouts at individualized training intensity with 1-minute rest periods.
Interventions
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High intensity interval training
Each training session will consist of a 3-5 minute warm-up, followed by 10 repetitions of 1-minute bouts at individualized training intensity with 1-minute rest periods.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age 40-70 years
* Body mass index 20-35 kg/m²
* Cleared by study physician from 12 lead EKG and medical history review
Exclusion Criteria
* Individuals currently doing HIIT
* Individuals currently participating in physical therapy for knee OA
* Individuals currently participating in another OA intervention study
* Received a corticosteroid or hyaluronic acid injection involved in the knee in the previous 3 weeks or scheduled for during the intervention
* Diagnosis of gout in the knee
* Diagnosis of Rheumatoid arthritis
* Diagnosis of Fibromyalgia
* Other systemic rheumatic disease
* Severe dementia or other memory loss
* Active diagnosis of psychosis or uncontrolled substance abuse disorder
* Hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 6 months
* Diabetics (medications include exogenous insulin)
* Total joint replacement knee surgery, other knee surgery, meniscus tear, or ACL tear in the past 12 months
* On a waiting list for total joint replacement
* Severely impaired hearing or speech
* Pregnant or planning to become pregnant in the next 8 weeks
* Inability to speak English
* Serious or terminal illness as indicated by referral to hospice or palliative care
* Nursing home residence
* Inability to ride a stationary bike
* Any other health problems that would prohibit safe participation in the study.
40 Years
70 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Principal Investigators
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Abbie Smith-Ryan, PhD
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Locations
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Applied Physiology Laboratory
Chapel Hill, North Carolina, United States
Countries
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References
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Smith-Ryan AE, Blue MNM, Anderson KC, Hirsch KR, Allen KD, Huebner JL, Muehlbauer MJ, Ilkayeva OR, Kraus VB, Kraus WE, Golightly YM, Huffman KM. Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study. Osteoarthr Cartil Open. 2020 Jun 10;2(4):100083. doi: 10.1016/j.ocarto.2020.100083. eCollection 2020 Dec.
Other Identifiers
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16-0829
Identifier Type: -
Identifier Source: org_study_id