Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses

NCT ID: NCT03034629

Last Updated: 2021-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-22

Study Completion Date

2021-09-27

Brief Summary

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The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Short-term aerobic exercise

One bout of moderate intensity exercise (75% of maximal predicated heart rate).

Group Type EXPERIMENTAL

Short-term aerobic exercise

Intervention Type BEHAVIORAL

One bout of moderate intensity exercise (75% of maximal predicated heart rate).

Interventions

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Short-term aerobic exercise

One bout of moderate intensity exercise (75% of maximal predicated heart rate).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adult males and females aged 18-70 years old.
* Primary language is English
* Exercise clearance

Exclusion Criteria

* Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
* History of migraines
* History of fainting spells of unknown or undetermined etiology that might constitute seizures
* History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy
* Any current history of psychiatric illness
* Any unstable medical condition
* No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
* The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs.
* The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, \& Safety of TMS Consensus Group, 2009)
* Any metal in the brain, skull or elsewhere unless approved by the responsible MD
* Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
* Intracranial lesion
* Substance abuse or dependence within the past six months
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Joyce Rios Gomes Osman

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joyce R Gomes-Osman, PT, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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University of Miami Miller School of Medicine

Miami, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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20161183

Identifier Type: -

Identifier Source: org_study_id