A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)

NCT ID: NCT03033511

Last Updated: 2021-07-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

748 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-07

Study Completion Date

2019-11-20

Brief Summary

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This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based chemotherapy.

Detailed Description

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Conditions

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Small Cell Lung Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Rovalpituzumab tesirine/dexamethasone

Rovalpituzumab tesirine/dexamethasone every 6 weeks (q6 wk); omitting every third cycle

Group Type EXPERIMENTAL

Rovalpituzumab tesirine

Intervention Type DRUG

Rovalpituzumab tesirine 0.3 mg/kg administered intravenously Day 1 of each 6-week cycle, omitting every third cycle

Dexamethasone

Intervention Type DRUG

Dexamethasone 8 mg administered orally (PO) twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.

Placebo

Placebo q6 wk; omitting every third cycle

Group Type EXPERIMENTAL

Placebo for dexamethasone

Intervention Type DRUG

Placebo for dexamethasone PO twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.

Placebo for rovalpituzumab tesirine

Intervention Type DRUG

Placebo for rovalpituzumab tesirine administered intravenously Day 1 of each 6-week cycle, omitting every third cycle

Interventions

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Placebo for dexamethasone

Placebo for dexamethasone PO twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.

Intervention Type DRUG

Placebo for rovalpituzumab tesirine

Placebo for rovalpituzumab tesirine administered intravenously Day 1 of each 6-week cycle, omitting every third cycle

Intervention Type DRUG

Rovalpituzumab tesirine

Rovalpituzumab tesirine 0.3 mg/kg administered intravenously Day 1 of each 6-week cycle, omitting every third cycle

Intervention Type DRUG

Dexamethasone

Dexamethasone 8 mg administered orally (PO) twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Histologically or cytologically confirmed extensive-stage disease small cell lung cancer (ED SCLC) at initial diagnosis with ongoing clinical benefit (stable disease \[SD\], partial response \[PR\], or complete response \[CR\]) following completion of 4 cycles of first-line platinum-based therapy
* Participant is eligible to be randomized at least 3 but no more than 9 weeks from Day 1 of the fourth cycle of first-line platinum-based chemotherapy.
* Participants with a history of central nervous system (CNS) metastases prior to the initiation of first-line platinum-based chemotherapy must have received definitive local treatment and have documentation of stable or improved CNS disease status
* Eastern Cooperative Oncology Group (ECOG) performance score of 0 or 1
* Participants must have adequate bone marrow, renal and hepatic function
* Availability of archived or representative tumor material for assessment of DLL3 expression

* Any disease-directed radiotherapy (except prophylactic cranial irradiation, palliative radiotherapy to a radiographically documented non-progressing lesion for symptom control, or pre-planned radiotherapy for CNS metastases present prior to start of first-line therapy and non-progressing) after last dose of first-line chemotherapy.
* Prior exposure to a pyrrolobenzodiazepine (PBD-based) or indolinobenzodiazepine-based drug, prior participation in a rovalpituzumab tesirine clinical trial, or known hypersensitivity or other contraindications to rovalpituzumab tesirine or excipient contained in the drug formulation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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AbbVie Inc.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Clearview Cancer Institute /ID# 156699

Huntsville, Alabama, United States

Site Status

University of South Alabama /ID# 160975

Mobile, Alabama, United States

Site Status

Highlands Oncology Group /ID# 156722

Fayetteville, Arkansas, United States

Site Status

Marin Cancer Care /ID# 159207

Greenbrae, California, United States

Site Status

Ucsd /Id# 157764

La Jolla, California, United States

Site Status

LA Hem-Oncology Med Group /ID# 156717

Los Angeles, California, United States

Site Status

Palo Alto Veterans Institute for Research /ID# 203695

Palo Alto, California, United States

Site Status

St Jude Hospital dba St Joseph /ID# 156526

Santa Rosa, California, United States

Site Status

Icri /Id# 157765

Whittier, California, United States

Site Status

Kaiser Permanente Lone Tree /ID# 159331

Lone Tree, Colorado, United States

Site Status

Christiana Care Health Service /ID# 159212

Newark, Delaware, United States

Site Status

Holy Cross Hospital /ID# 156716

Fort Lauderdale, Florida, United States

Site Status

University of Florida - Archer /ID# 155799

Gainesville, Florida, United States

Site Status

Memorial Cancer Institute /ID# 156673

Hollywood, Florida, United States

Site Status

Memorial Cancer Institute /ID# 164052

Hollywood, Florida, United States

Site Status

Cancer Specialists of North Florida - Southpoint /ID# 156595

Jacksonville, Florida, United States

Site Status

Georgia Cancer Center /ID# 201894

Atlanta, Georgia, United States

Site Status

Southeastern Regional Medical /ID# 163064

Newnan, Georgia, United States

Site Status

St. Luke's Mountain States Tumor Institute - Boise /ID# 156691

Boise, Idaho, United States

Site Status

NorthShore University HealthSystem - Evanston Hospital /ID# 156664

Evanston, Illinois, United States

Site Status

Ingalls Memorial Hosp /ID# 156685

Harvey, Illinois, United States

Site Status

Goshen Center for Cancer Care /ID# 156682

Goshen, Indiana, United States

Site Status

Ashland-Bellefonte Cancer Ctr /ID# 202901

Ashland, Kentucky, United States

Site Status

University of Louisville /ID# 156683

Louisville, Kentucky, United States

Site Status

Ochsner Clinic Foundation /ID# 159136

Baton Rouge, Louisiana, United States

Site Status

Henry Ford Health System /ID# 156712

Detroit, Michigan, United States

Site Status

Sparrow Regional Cancer Center, Sparrow Health System /ID# 156590

Lansing, Michigan, United States

Site Status

Mayo Clinic - Rochester /ID# 160181

Rochester, Minnesota, United States

Site Status

MidAmerica Division, Inc. /ID# 163530

Kansas City, Missouri, United States

Site Status

Billings Clinic /ID# 201788

Billings, Montana, United States

Site Status

Nebraska Hematology Oncology /ID# 156534

Lincoln, Nebraska, United States

Site Status

MD Anderson Cancer Center at Cooper - Camden /ID# 156681

Camden, New Jersey, United States

Site Status

Northwell Health - Monter Cancer Center /ID# 159252

Lake Success, New York, United States

Site Status

Icahn School of Med Mt. Sinai /ID# 159210

New York, New York, United States

Site Status

Stony Brook University Hospital /ID# 159272

Stony Brook, New York, United States

Site Status

Montefiore Medical Center /ID# 201845

The Bronx, New York, United States

Site Status

Duke University Medical Center /ID# 156706

Durham, North Carolina, United States

Site Status

Cone Health /ID# 156689

Greensboro, North Carolina, United States

Site Status

Cone Health /ID# 163612

Greensboro, North Carolina, United States

Site Status

Eastern Carolina University /ID# 159264

Greenville, North Carolina, United States

Site Status

Gabrail Cancer Center Research /ID# 156667

Canton, Ohio, United States

Site Status

Kaiser Permanente, NW /ID# 201793

Portland, Oregon, United States

Site Status

Thomas Jefferson University /ID# 156719

Philadelphia, Pennsylvania, United States

Site Status

VA Pittsburgh HealthcareSystem /ID# 159284

Pittsburgh, Pennsylvania, United States

Site Status

Rhode Island Hospital /ID# 160834

Providence, Rhode Island, United States

Site Status

Sarah Cannon Research Institute-Chattanooga /ID# 202933

Chattanooga, Tennessee, United States

Site Status

Thompson Cancer Survival Ctr /ID# 202460

Knoxville, Tennessee, United States

Site Status

Tennessee Oncology-Nashville Centennial /ID# 161168

Nashville, Tennessee, United States

Site Status

Univ Medical Ctr Brackenridge /ID# 155798

Austin, Texas, United States

Site Status

Parkland Health and Hosp Syste /ID# 170933

Dallas, Texas, United States

Site Status

UT Southwestern Medical Center /ID# 157848

Dallas, Texas, United States

Site Status

Houston Methodist Hospital - Scurlock Tower /ID# 202323

Houston, Texas, United States

Site Status

Medical Oncology Associates /ID# 156715

Spokane, Washington, United States

Site Status

West Virginia Univ School Med /ID# 156687

Morgantown, West Virginia, United States

Site Status

Coffs Harbour Hospital /ID# 158880

Coffs Harbour, New South Wales, Australia

Site Status

Gosford Hospital /ID# 158884

Gosford, New South Wales, Australia

Site Status

Newcastle Private Hospital /ID# 203506

Lambton Heights, New South Wales, Australia

Site Status

Royal North Shore Hospital /ID# 158881

Saint Leonards, New South Wales, Australia

Site Status

Calvary North Adelaide Hospita /ID# 161701

Adelaide, South Australia, Australia

Site Status

Sunshine Hospital /ID# 161700

St Albans, Victoria, Australia

Site Status

Affinity Clinical Research Ser /ID# 158887

Nedlands, , Australia

Site Status

SMZ Baumgartner Höhe, Otto-Wagner-Spital und Pflegezentrum /ID# 201776

Vienna, Vienna, Austria

Site Status

Krankenhaus Nord - Klinik Floridsdorf /ID# 201768

Vienna, Vienna, Austria

Site Status

LKH-Univ. Klinikum Graz /ID# 159563

Graz, , Austria

Site Status

Ordensklinikum Linz GmbH, Elisabethinen /ID# 159564

Linz, , Austria

Site Status

Salzburger Landeskliniken (SALK) /ID# 201779

Salzburg, , Austria

Site Status

Bobruysk Interdistrict Onco. /ID# 169393

Babruysk, , Belarus

Site Status

State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159383

Lesnoy, , Belarus

Site Status

Mogilev Reg Clin Oncology Dis /ID# 159384

Mogilev, , Belarus

Site Status

CHU Saint-Pierre /ID# 159009

Brussels, Brussels Capital, Belgium

Site Status

Grand Hôpital de Charleroi /ID# 159006

Charleroi, Hainaut, Belgium

Site Status

ZNA Middelheim /ID# 159007

Antwerp, , Belgium

Site Status

Hopital de Jolimont /ID# 159005

Haine-Saint-Paul, , Belgium

Site Status

CHU Charleroi (Vesale) /ID# 159008

Montigny-le-Tilleul, , Belgium

Site Status

Hospital Evangelico de Cachoei /ID# 159657

Cachoeiro de Itapemirim, Espírito Santo, Brazil

Site Status

Liga Norte Rio Grandense Cont. /ID# 159011

Natal, Rio Grande do Norte, Brazil

Site Status

Associação Hospital de Caridade Ijuí - Centro de Tratamento de Cancer - CACON /ID# 159013

Ijuí, Rio Grande do Sul, Brazil

Site Status

Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159661

Passo Fundo, Rio Grande do Sul, Brazil

Site Status

Hospital Sao Lucas da PUCRS /ID# 159662

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159012

Barretos, São Paulo, Brazil

Site Status

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159659

São José do Rio Preto, São Paulo, Brazil

Site Status

Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159658

Rio de Janeiro, , Brazil

Site Status

UMHAT Tsaritsa Joanna - ISUL /ID# 159638

Sofia, , Bulgaria

Site Status

UMHAT Sv. Ivan Rilski /ID# 159639

Sofia, , Bulgaria

Site Status

British Columbia Cancer Agency /ID# 163721

Surrey, British Columbia, Canada

Site Status

Brampton Civic Hospital /ID# 204425

Brampton, Ontario, Canada

Site Status

R.S. McLaughlin Durham Regional /ID# 170870

Oshawa, Ontario, Canada

Site Status

Princess Margaret /ID# 170868

Toronto, Ontario, Canada

Site Status

Windsor Regional Cancer Centre /ID# 170869

Windsor, Ontario, Canada

Site Status

Iucpq-Ul /Id# 159530

Québec, Quebec, Canada

Site Status

Fujian Provincial Cancer Hospital /ID# 204864

Fuzhou, Fujian, China

Site Status

Harbin Medical University Cancer Hospital /Id# 203638

Harbin, Heilongjiang, China

Site Status

Hubei Cancer Hospital /ID# 202886

Wuhan, Hubei, China

Site Status

Jilin Cancer Hosptial /ID# 204060

Changchun, Jilin, China

Site Status

The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203641

Ürümqi, Xinjiang, China

Site Status

Yunnan Cancer Hospital /ID# 204911

Kunming, Yunnan, China

Site Status

Zhejiang Cancer hospital /ID# 204640

Hangzhou, Zhejiang, China

Site Status

Sir Run Run Shaw Hospital /ID# 206802

Jianggan Hangzhou, Zhejiang, China

Site Status

Jiangsu Province Hospital /ID# 205183

Nanjing, , China

Site Status

4th Military Medical Universit /ID# 203986

Xi'an, , China

Site Status

First Affiliated Hospital of Xi'an Jiaotong University /ID# 203733

Xi'an, , China

Site Status

Henan Cancer Hospital /ID# 203983

Zhengzhou Henan, , China

Site Status

Henan Cancer Hospital /ID# 204636

Zhengzhou Henan, , China

Site Status

Klinicki bolnicki centar Sestre milosrdnice /ID# 159090

Zagreb, City of Zagreb, Croatia

Site Status

Klinika za plucne bolesti Jordanovac /ID# 159505

Zagreb, City of Zagreb, Croatia

Site Status

Klinicki bolnicki centar Rijeka /ID# 159504

Rijeka, Primorje-Gorski Kotar County, Croatia

Site Status

Thomayerova nemocnice /ID# 159062

Prague, Praha 4, Czechia

Site Status

Nemocnice Rudolfa a Stefanie /ID# 159655

Benešov, , Czechia

Site Status

Nemocnice Horovice a.s. /ID# 161186

Hořovice, , Czechia

Site Status

Vitkovicka nemocnice a. s. /ID# 161187

Ostrava, , Czechia

Site Status

FN Plzen /ID# 204097

Pilsen, , Czechia

Site Status

Oblastni Nemocnice Pribram /ID# 159654

Příbram, , Czechia

Site Status

Rigshospitalet /ID# 158055

Copenhagen Ø, Capital Region, Denmark

Site Status

Herlev Hospital /ID# 158053

Herlev, Capital Region, Denmark

Site Status

Aalborg University Hospital /ID# 203737

Aalborg, North Denmark, Denmark

Site Status

Odense Universitets Hospital /ID# 158054

Odense C, Region Syddanmark, Denmark

Site Status

East Tallinn Central Hospital /ID# 160019

Tallinn, , Estonia

Site Status

North Estonian Medical Centre /ID# 159779

Tallinn, , Estonia

Site Status

Docrates Cancer Center /ID# 159591

Helsinki, , Finland

Site Status

CHU Hopital Nord /ID# 160543

Marseille, Bouches-du-Rhone, France

Site Status

Hopital Haut-Lévêque /ID# 160547

Pessac, Gironde, France

Site Status

CHU Calmette /ID# 202706

Lille, Hauts-de-France, France

Site Status

Centre Leon Berard /ID# 160550

Lyon, Rhone, France

Site Status

Centre Hosp Intercommunal de Creteil /ID# 162686

Créteil, Val-de-Marne, France

Site Status

Hopital Tenon /ID# 160541

Paris, , France

Site Status

Hospital Pontchaillou /ID# 160544

Rennes, , France

Site Status

Nouvel Hopital Civil (NHC) /ID# 204427

Strasbourg, , France

Site Status

Hopital Larrey /ID# 204290

Toulouse, , France

Site Status

Institut Curie /ID# 207514

Paris, Île-de-France Region, France

Site Status

KH Martha-Maria Halle Dolau /ID# 158794

Halle, Saxony-Anhalt, Germany

Site Status

Charite Universitatsmedizin Berlin Campus Virchow Klinikum /ID# 158783

Berlin, , Germany

Site Status

Evangelische Lungenklinik Berl /ID# 158935

Berlin, , Germany

Site Status

Asklepios Fachkliniken M. Gaut /ID# 158789

Gauting, , Germany

Site Status

Thoraxklinik Heidelberg gGmbH /ID# 158871

Heidelberg, , Germany

Site Status

Lungenklinik Hemer /ID# 158790

Hemer, , Germany

Site Status

Klinikum Kassel /ID# 158786

Kassel, , Germany

Site Status

Klinik Loewenstein GmbH /ID# 158870

Löwenstein, , Germany

Site Status

Fachkliniken Wangen /ID# 160779

Wangen, , Germany

Site Status

Metropolitan General Hospital /ID# 202422

Cholargós, Attica, Greece

Site Status

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159160

Athens, , Greece

Site Status

Metropolitan Hospital /ID# 159157

Athens, , Greece

Site Status

University General Hospital of Heraklion PA.G.N.I /ID# 202409

Heraklion, , Greece

Site Status

University Hospital of Ioannin /ID# 159158

Ioannina, , Greece

Site Status

General Oncological Hospital /ID# 159159

Nea Kifissia, , Greece

Site Status

Euromedica General Clinic /ID# 159156

Thessaloniki, , Greece

Site Status

Queen Elizabeth Hospital /ID# 159565

Kowloon, , Hong Kong

Site Status

Princess Margaret Hospital /ID# 162810

Lai Chi Kok, , Hong Kong

Site Status

Tuen Mun Hospital /ID# 162435

Tuenmen, , Hong Kong

Site Status

CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 158962

Miskolc, Borsod-Abauj Zemplen county, Hungary

Site Status

Orszagos Koranyi Pulmonologiai Intezet /ID# 158953

Budapest XII, Budapest, Hungary

Site Status

Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz - Pulmonologia /ID# 202466

Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary

Site Status

Semmelweis Egyetem /ID# 158955

Budapest, , Hungary

Site Status

Csongrad Megyei Mellkasi Beteg /ID# 158952

Deszk, , Hungary

Site Status

St. James's Hospital /ID# 159712

Dublin, Dublin, Ireland

Site Status

Cork University Hospital /ID# 159715

Cork, , Ireland

Site Status

St Vincent's University Hosp /ID# 161678

Dublin, , Ireland

Site Status

Beaumont Hospital /ID# 159711

Dublin, , Ireland

Site Status

University Hospital Limerick /ID# 159714

Limerick, , Ireland

Site Status

University Hospital Waterford /ID# 159713

Waterford, , Ireland

Site Status

Rabin Medical Center /ID# 159764

Petakh Tikva, Tel Aviv, Israel

Site Status

Tel Aviv Sourasky Medical Center /ID# 161467

Tel Aviv, Tel Aviv, Israel

Site Status

Soroka University Medical Center /ID# 159762

Beersheba, , Israel

Site Status

Assaf Harofeh Medical Center /ID# 201883

Be’er Ya‘aqov, , Israel

Site Status

Rambam Health Care Campus /ID# 202336

Haifa, , Israel

Site Status

Hadassah /ID# 159763

Jerusalem, , Israel

Site Status

Meir Medical Center /ID# 159761

Kfar Saba, , Israel

Site Status

Sheba Medical Center /ID# 159760

Ramat Gan, , Israel

Site Status

IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 160898

Meldola, Emilia-Romagna, Italy

Site Status

Policlinico Universitario Campus Bio-Medico /ID# 160874

Rome, Lazio, Italy

Site Status

AUSL 8 Arezzo Ospedale San Don /ID# 160897

Arezzo, , Italy

Site Status

A.O.U. San Luigi Gonzaga /ID# 158916

Orbassano, , Italy

Site Status

Ospedale Santa Maria delle Cro /ID# 158911

Ravenna, , Italy

Site Status

IFO Istituto Nazionale Tumori /ID# 158912

Rome, , Italy

Site Status

Aichi Cancer Center Hospital /ID# 164976

Nagoya, Aichi-ken, Japan

Site Status

National Cancer Center Hospital East /ID# 165721

Kashiwa-shi, Chiba, Japan

Site Status

Kyushu University Hospital /ID# 165722

Fukuoka, Fukuoka, Japan

Site Status

Kurume University Hospital /ID# 164595

Kurume-shi, Fukuoka, Japan

Site Status

Kanazawa University Hospital /ID# 165127

Kanazawa, Ishikawa-ken, Japan

Site Status

Kanagawa Cardiovascular and Respiratory Center /ID# 165015

Yokohama, Kanagawa, Japan

Site Status

Yokohama City University Hospital /ID# 165746

Yokohama, Kanagawa, Japan

Site Status

Japanese Red Cross Okayama Hospital /ID# 165157

Okayama, Okayama-ken, Japan

Site Status

Kansai Medical University Hospital /ID# 165054

Hirakata-shi, Osaka, Japan

Site Status

Kindai University Hospital /ID# 166395

Osaka-sayama-shi, Osaka, Japan

Site Status

Shizuoka Cancer Center /ID# 166272

Sunto-gun, Shizuoka, Japan

Site Status

Tokushima University Hospital /ID# 166105

Tokushima, Tokushima, Japan

Site Status

National Cancer Center Hospital /ID# 166547

Chuo-ku, Tokyo, Japan

Site Status

Showa University Hospital /ID# 165575

Shinagawa-ku, Tokyo, Japan

Site Status

Wakayama Medical University /ID# 165946

Wakayama, Wakayama, Japan

Site Status

Hyogo Cancer Center /ID# 165138

Akashi, , Japan

Site Status

National Hospital Organization Himeji Medical Center /ID# 165899

Himeji, , Japan

Site Status

Matsusaka City Hospital /ID# 166156

Matsusaka-shi MIE, , Japan

Site Status

Osaka City General Hospital /ID# 165714

Osaka, , Japan

Site Status

Hokkaido Cancer Center /ID# 165236

Sapporo, , Japan

Site Status

Sendai Kousei Hospital /ID# 166491

Sendai, , Japan

Site Status

Kanagawa Cancer Center /ID# 165814

Yokohama, , Japan

Site Status

Pauls Stradins Clinical /ID# 158715

Riga, , Latvia

Site Status

Riga East Clinical University /ID# 158716

Riga, , Latvia

Site Status

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 160016

Kaunas, Kaunas County, Lithuania

Site Status

Klaipeda University Hospital /ID# 160018

Klaipėda, , Lithuania

Site Status

National Cancer Institute /ID# 160017

Vilnius, , Lithuania

Site Status

Centro de Investigación Clinica Chapultepec /ID# 160965

Morelia, Michoacán, Mexico

Site Status

Health Pharma professional Ser /ID# 160734

Mexico City, , Mexico

Site Status

Jeroen Bosch Ziekenhuis /ID# 158081

's-Hertogenbosch, , Netherlands

Site Status

Meander Medisch Centrum /ID# 159064

Amersfoort, , Netherlands

Site Status

Rijnstate /ID# 159063

Arnhem, , Netherlands

Site Status

Amphia Ziekenhuis /ID# 159065

Breda, , Netherlands

Site Status

Catharina Ziekenhuis /ID# 158082

Eindhoven, , Netherlands

Site Status

Maastricht Universitair Medisch Centrum /ID# 161669

Maastricht, , Netherlands

Site Status

Universitair Medisch Centrum Utrecht /ID# 158083

Utrecht, , Netherlands

Site Status

Akershus universitetssykehus /ID# 201682

Nordbyhagen, Akershus, Norway

Site Status

Drammen Sykehus /ID# 159572

Drammen, Buskerud, Norway

Site Status

Haukeland University Hospital /ID# 159573

Bergen, Hordaland, Norway

Site Status

St. Olavs Hospital HF /ID# 163110

Trondheim, Sor-Trondelag, Norway

Site Status

Radiumhospitalet, OUS /ID# 159574

Oslo, , Norway

Site Status

Stavanger Universitetssykehus /ID# 159575

Stavanger, , Norway

Site Status

Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 159604

Rzeszów, Podkarpackie Voivodeship, Poland

Site Status

Wojewodzki Szpital Specjalisty /ID# 159603

Bytom, , Poland

Site Status

Szpitale Pomorskie Sp. z o.o /ID# 159605

Gdynia, , Poland

Site Status

Centro Hospitalar Lisboa Norte, EPE /ID# 159957

Lisbon, Lisbon District, Portugal

Site Status

IPO Lisboa FG, EPE /ID# 159949

Lisbon, , Portugal

Site Status

Hospital da Luz, SA /ID# 159954

Lisbon, , Portugal

Site Status

Unidade Local Saude Matosinhos /ID# 159950

Matosinhos Municipality, , Portugal

Site Status

Centro Hospitalar do Porto EPE /ID# 203582

Porto, , Portugal

Site Status

Hospital CUF Porto /ID# 159955

Porto, , Portugal

Site Status

IPO Porto FG, EPE /ID# 159956

Porto, , Portugal

Site Status

National Medical Research Cntr /ID# 169885

Moscow, Moscow Oblast, Russia

Site Status

Arkhangelsk clinical oncology /ID# 159367

Arkhangelsk, , Russia

Site Status

Kaluga Regional Clinical Oncol /ID# 160180

Kaluga, , Russia

Site Status

Clinical Onco Dispensary /ID# 159365

Omsk, , Russia

Site Status

PMI Euromedservice /ID# 159369

Pushkin, , Russia

Site Status

LLC Novaya Clinica /ID# 205523

Pyatigorsk, , Russia

Site Status

LLC BioEq Ltd. /ID# 159368

Saint Petersburg, , Russia

Site Status

OOO Centre of Palliative Medicine De Vita /ID# 206855

Saint Petersburg, , Russia

Site Status

N.N. Petrov Research Inst Onc /ID# 159370

Saint Petersburg, , Russia

Site Status

Ogarev Mordovia State Univ /ID# 205742

Saransk, , Russia

Site Status

Smolensk Regional Onc Clin Dis /ID# 159372

Smolensk, , Russia

Site Status

Clinical Center Serbia /ID# 160902

Belgrade, Beograd, Serbia

Site Status

Clin Hosp Ctr Bezanijska Kosa /ID# 160903

Belgrade, Beograd, Serbia

Site Status

Clinical Center of Nis /ID# 160905

Niš, Nisavski Okrug, Serbia

Site Status

Institut za onkologiju i radio /ID# 160904

Belgrade, , Serbia

Site Status

Institute For Pulmonary Diseas /ID# 164250

Kamenitz, , Serbia

Site Status

Cancercare Langenhoven Drive Oncology Centre /ID# 159126

Port Elizabeth, Eastern Cape, South Africa

Site Status

Dr Albert, Bouwer and Jordaan Incorporated /ID# 158873

Pretoria, Gauteng, South Africa

Site Status

Mary Potter Oncology Centre /ID# 158877

Pretoria, Gauteng, South Africa

Site Status

The Oncology Centre /ID# 158872

Durban, KwaZulu-Natal, South Africa

Site Status

Cape Town Oncology Trials /ID# 201311

Cape Town, Western Cape, South Africa

Site Status

Cancercare Outeniqua Oncology Unit /ID# 200689

George, Western Cape, South Africa

Site Status

Dong-A University Hospital /ID# 159305

Busan, Busan Gwang Yeogsi, South Korea

Site Status

CHA Bundang Medical center CHA University /ID# 161281

Seongnam-si, Gyeonggido, South Korea

Site Status

Kyungpook National University Chilgok Hospital /ID# 159301

Daegu, Seoul Teugbyeolsi, South Korea

Site Status

Samsung Medical Center /ID# 159304

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Korea University Guro Hospital /ID# 159302

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Chungbuk National University /ID# 159300

Cheongju-si, , South Korea

Site Status

Severance Hospital /ID# 159297

Seoul, , South Korea

Site Status

Asan Medical Center /ID# 159299

Seoul, , South Korea

Site Status

Hospital Teresa Herrera - CHUAC /ID# 164368

A Coruña, A Coruna, Spain

Site Status

Hospital Regional de Malaga /ID# 164371

Málaga, Malaga, Spain

Site Status

Hospital Parc de Salut del Mar /ID# 159690

Barcelona, , Spain

Site Status

Hospital Universitario Vall d'Hebron /ID# 159708

Barcelona, , Spain

Site Status

Hospital Clinico Universitario San Carlos /ID# 159706

Madrid, , Spain

Site Status

Hospital Universitario Fundacion Jimenez Diaz /ID# 159693

Madrid, , Spain

Site Status

Hospital Universitario La Paz /ID# 159692

Madrid, , Spain

Site Status

Hospital Clinico Universitario Lozano Blesa /ID# 159709

Zaragoza, , Spain

Site Status

Centralsjukhuset, Karlstad /ID# 163451

Karlstad, Värmland County, Sweden

Site Status

Sahlgrenska US Gbg /ID# 159524

Gothenburg, Västra Götaland County, Sweden

Site Status

University Hospital Linkoping /ID# 159046

Linköping, , Sweden

Site Status

Karolinska Univ Sjukhuset /ID# 159649

Solna, , Sweden

Site Status

Uppsala University Hospital /ID# 159052

Uppsala, , Sweden

Site Status

Hopitaux Universitaires de Geneve /ID# 160603

Geneva, Canton of Geneva, Switzerland

Site Status

Kantonsspital St. Gallen /ID# 160604

Sankt Gallen, Canton of St. Gallen, Switzerland

Site Status

Universitaetsspital Basel /ID# 160605

Basel, , Switzerland

Site Status

Luzerner Kantonsspital /ID# 160607

Lucerne, , Switzerland

Site Status

Kantonsspital Winterthur /ID# 161379

Winterthur, , Switzerland

Site Status

China Medical University Hosp /ID# 158981

Taichung, Taichung, Taiwan

Site Status

National Cheng Kung University Hospital /ID# 158799

Tainan City, Tainan, Taiwan

Site Status

National Taiwan Univ Hosp /ID# 159049

Taipei City, Taipei, Taiwan

Site Status

Tri-Service General Hospital /ID# 158980

Taipei City, Taipei, Taiwan

Site Status

Dalin Tzu Chi General Hospital /ID# 158983

Dalin Township, , Taiwan

Site Status

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 158798

Kaohsiung City, , Taiwan

Site Status

Taichung Veterans General Hosp /ID# 159047

Taichung, , Taiwan

Site Status

Taipei Veterans General Hosp /ID# 203699

Taipei, , Taiwan

Site Status

Hacettepe University Medical Faculty /ID# 159242

Altindağ, Ankara, Turkey (Türkiye)

Site Status

Erciyes University Medical Fac /ID# 202269

Melikgazi, Kayseri, Turkey (Türkiye)

Site Status

Ataturk Gogus Hastalikl /ID# 159556

Ankara, , Turkey (Türkiye)

Site Status

Akdeniz Universitesi Tip Fakul /ID# 160791

Antalya, , Turkey (Türkiye)

Site Status

Bezmi alem Vakif Universitesi /ID# 202267

Istanbul, , Turkey (Türkiye)

Site Status

Istanbul Medeniyet Universites /ID# 200126

Istanbul, , Turkey (Türkiye)

Site Status

Ege University Medical Faculty /ID# 159243

Izmir, , Turkey (Türkiye)

Site Status

Dr. Suat Seren Gogus Has /ID# 159244

Izmir, , Turkey (Türkiye)

Site Status

Inonu University /ID# 159245

Malatya, , Turkey (Türkiye)

Site Status

CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159131

Zaporizhzhia, Zaporizhzhia Oblast, Ukraine

Site Status

Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 159864

Chernivtsi, , Ukraine

Site Status

Municipal institution Multifie /ID# 159130

Dnipro, , Ukraine

Site Status

Regional Center of Oncology /ID# 159132

Kharkiv, , Ukraine

Site Status

PE PMC Acinus, Medical and Diagnostic Center /ID# 165543

Kropyvnytskyi, , Ukraine

Site Status

Volyn Regional Medical Oncology Centre /ID# 159133

Lutsk, , Ukraine

Site Status

Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159865

Uzhhorod, , Ukraine

Site Status

Cheltenham General Hospital /ID# 169096

Cheltenham, Gloucestershire, United Kingdom

Site Status

Queen Elizabeth Medical Centre /ID# 162899

Birmingham, , United Kingdom

Site Status

The Royal Bournemouth Hospital /ID# 159039

Bournemouth, , United Kingdom

Site Status

Colchester General Hospital /ID# 159042

Colchester, , United Kingdom

Site Status

Hereford County Hospital /ID# 159038

Hereford, , United Kingdom

Site Status

St. George's Healthcare NHS /ID# 202416

London, , United Kingdom

Site Status

Charing Cross Hospital /ID# 161399

London, , United Kingdom

Site Status

Maidstone Hospital /ID# 159043

Maidstone, , United Kingdom

Site Status

Christie NHS Foundation Trust /ID# 159037

Manchester, , United Kingdom

Site Status

The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 159044

Newcastle upon Tyne, , United Kingdom

Site Status

Torbay Hospital - So Devon HC /ID# 159041

Torquay, , United Kingdom

Site Status

Countries

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United States Australia Austria Belarus Belgium Brazil Bulgaria Canada China Croatia Czechia Denmark Estonia Finland France Germany Greece Hong Kong Hungary Ireland Israel Italy Japan Latvia Lithuania Mexico Netherlands Norway Poland Portugal Russia Serbia South Africa South Korea Spain Sweden Switzerland Taiwan Turkey (Türkiye) Ukraine United Kingdom

References

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Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, Nakanishi Y, Okamoto I. Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. Lung Cancer. 2018 Jan;115:116-120. doi: 10.1016/j.lungcan.2017.11.018. Epub 2017 Nov 22.

Reference Type DERIVED
PMID: 29290251 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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2016-003503-64

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

M16-298

Identifier Type: -

Identifier Source: org_study_id

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