Study of Bevacizumab(BAT1706) and Comparators in Healthy Subjects

NCT ID: NCT03030430

Last Updated: 2018-07-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 128 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-03-15
• Study Completion Date: 2017-06-28

Brief Summary

The purpose of this study is to establish PK similarity in the treatment of BAT1706 and comparators.

Detailed Description

This is a Phase I, randomized, double-blind, single-dose, 3-arm parallel group study to compare the PK, and to evaluate the safety, tolerability and immunogenicity, of BAT1706, EU-Avastin and US-Avastin after a single IV infusion in healthy adult male subjects.

A total of 129 healthy male subjects who meet the required entry criteria will be randomly assigned to one of three treatment groups in a 1:1:1 ratio to receive a single IV infusion of either BAT1706, EU-Avastin or US-Avastin. A total of 117 evaluable subjects are required.

Initially, subjects will be administered the study drug in staggered groups; the first group will comprise 3 subjects, the second group 6 subjects and the third group 9 subjects. Within each group subjects will be randomized to ensure equal numbers of subjects receive each of the three treatments.

There will be at least 48 hours between administrations of study drug to each group. Prior to administration of study drug to the next group, the safety and tolerability findings of the preceding group will be reviewed by the Principal Investigator. The next group will be dosed provided there are no serious or unexpected drug-related safety issues. Each subject will be required to remain in the clinical center for 48 hours after dosing for safety evaluation.

After the first 3 groups have been evaluated, the Principal Investigator will decide whether to proceed with continuous enrolment according to the clinical center capability.

Conditions

NSCLC

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

BAT1706

BAT1706 injection

Group Type: EXPERIMENTAL

BAT1706 injection

Intervention Type: BIOLOGICAL

1mg/kg, IV on day 1

EU-sourced Avastin

EU-sourced Avastin

Group Type: ACTIVE_COMPARATOR

EU-sourced Avastin

Intervention Type: BIOLOGICAL

1mg/kg, IV on day 1

US-sourced Avastin

US-sourced Avastin

Group Type: ACTIVE_COMPARATOR

US-sourced Avastin

Intervention Type: BIOLOGICAL

1mg/kg, IV on day 1

Interventions

BAT1706 injection

1mg/kg, IV on day 1

Intervention Type: BIOLOGICAL

EU-sourced Avastin

1mg/kg, IV on day 1

Intervention Type: BIOLOGICAL

US-sourced Avastin

1mg/kg, IV on day 1

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

1. Adult males aged 18 to 50 years inclusive and body weight 65 to 100kg.

2. Subjects who are healthy as determined by pre-study medical history, physical examination, vital signs and 12 ECG.

3. Subjects whose clinical laboratory test results are normal, or where outside the reference range are judged as not clinical relevant.

Exclusion Criteria

1. Have a history of and/or current clinically significant gastrointestinal, renal, hepatic, cardiovascular, haematological, pulmonary, neurologic, metabolic, psychiatric or allergic disease excluding mild asymptomatic seasonal allergies.

2. Subject with a psychiatric disorder or considered unsuitable for inclusion by the investigator.

3. History or current clinically significant, excluding mild asymptomatic seasonal allergies, hypersensitivity or allergic reactions including known or suspected drug hypersensitivity to any component of the study drug formulations or comparable drugs.

4. Any biological drug within 3 months or monoclonal antibodies within 9 months of study drug administration.

5. Intake of herbal remedies within 14 days prior to study drug administration.

6. History of alcohol abuse or a positive alcohol test on screening or admission to the clinical center.

7. Any persons who are:an employee of the Principal Investigator, clinical center, Clinical Research Organization (CRO) or Sponsor;a relative of an employee of the clinical center, the Investigators, CRO or the Sponsor.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Bio-Thera Solutions

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Chris Wynne, Medical Doc

Role: PRINCIPAL_INVESTIGATOR

Director

Locations

Christchurch Clinical Studies Trust Ltd (CCST)

Christchurch, , New Zealand

Countries

New Zealand

References

Wu X, Wynne C, Xu C, Gan Y, Wang C, Thomas BE, Yu JC, Li S, Zhang L. A Global Phase I Clinical Study Comparing the Safety and Pharmacokinetics of Proposed Biosimilar BAT1706 and Bevacizumab (Avastin(R)) in Healthy Male Subjects. BioDrugs. 2019 Jun;33(3):335-342. doi: 10.1007/s40259-019-00352-7.

Reference Type: DERIVED

PMID: 31016568 (View on PubMed)

Other Identifiers

BAT-1706-001

Identifier Type: -

Identifier Source: org_study_id