Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis

NCT ID: NCT03014284

Last Updated: 2018-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-20

Study Completion Date

2018-09-12

Brief Summary

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This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.

Detailed Description

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Conditions

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Colon Cancer Colitis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Able to provide informed consent (or have consent provided through a guardian)
* No immune-modulating drug use during study or within 30 days prior to enrollment
* Having colon material collected as part of standard of care

Exclusion Criteria

* Unable to provide informed consent (or have consent provided through a guardian)
* Not having colon material collected as part of standard of care
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The University of Texas Health Science Center at San Antonio

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tyler Curiel, MD

Role: PRINCIPAL_INVESTIGATOR

University of Texas Health Science Center at the Cancer Therapy and Research Center

Locations

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Cancer Therapy & Research Center at UTHSCSA

San Antonio, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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HSC20160555H

Identifier Type: OTHER

Identifier Source: secondary_id

CTMS 16-0101

Identifier Type: -

Identifier Source: org_study_id

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