Immunotherapy Vaccine and Herceptin in Breast Cancer

NCT ID: NCT03014076

Last Updated: 2017-01-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-01-31
• Study Completion Date: 2017-01-31

Brief Summary

The purpose of this trial is to determine if combination immunotherapy with HER2/neu GP2 peptide + GM-CSF vaccine and trastuzumab is safe and immunologically effective in treatment of patients with HER2/neu over-expressing breast cancer in the adjuvant setting. While not a primary endpoint, time to recurrence is measured for enrolled subjects. The objectives of the study are the following:

• Assess safety and document local and systemic toxicity to combination immunotherapy with GP2 peptide + GM-CSF vaccine and trastuzumab
• Evaluate the in vitro and in vivo immunologic responses to combination immunotherapy of GP2 peptide + GM-CSF vaccine and trastuzumab
• Determine maximum tolerated dose and optimal biologic dose for the combination immunotherapy of GP2 peptide + GM-CSF vaccine and trastuzumab

Conditions

Breastcancer

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

GP2 peptide + GM-CSF + trastuzumab

HLA-A2+/A3+ subjects receive GP2 + GM-CSF vaccine and trastzumab

Group Type: EXPERIMENTAL

GP2 peptide + GM-CSF vaccine plus trastuzumab

Intervention Type: DRUG

HLA-A2+/A3+ subjects are given the GP2 peptide vaccine plus trastuzumab

Trastuzumab

HLA-A2-/A3- subjects followed as controls receiving trastuzumab.

Group Type: ACTIVE_COMPARATOR

Trastuzumab

Intervention Type: DRUG

HLA-A2-/A3- patients are followed as controls receiving trastuzumab only.

Interventions

GP2 peptide + GM-CSF vaccine plus trastuzumab

HLA-A2+/A3+ subjects are given the GP2 peptide vaccine plus trastuzumab

Intervention Type: DRUG

Trastuzumab

HLA-A2-/A3- patients are followed as controls receiving trastuzumab only.

Intervention Type: DRUG

Other Intervention Names

Herceptin

Eligibility Criteria

Inclusion Criteria

• Age > 18 years
• HER2/neu+ over-expressing breast cancer (IHC 3+ or FISH ≥2.0)
• Patients who are receiving adjuvant trastuzumab as standard of care treatment
• Completion of breast cancer therapy (i.e., surgery, radiation, and chemotherapy as appropriate per standard of care for patients' specific cancer) to exclude trastuzumab (Patients on oral hormonal therapy as part of their adjuvant breast cancer treatment will be maintained on their regimens.)
• Enrollment must occur so that patients' trastuzumab treatment and vaccine schedule overlap for all 6 vaccinations and so that first vaccination occurs after a standard of care Multiple Gated Acquisition Scan (MUGA)
• ECOG performance status (PS) 0-1
• Clinically cancer-free (no evidence of disease; excluding +CTC)
• If the patient is of childbearing potential, she must be willing to practice adequate contraception through the study treatment period and for 2 months after completion of the injection sites
• Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria

• Clinical and/or radiographic evidence of residual or persistent breast cancer
• Receiving immunosuppressive therapy to include methotrexate or steroids (note: the use of prednisone, or equivalent, <2.0mg/day, is allowed)
• Tbili >1.8, creatinin >2, hemoglobin <10, platelets <100,000/mm³, WBC <2,000
• Active pulmonary disease requiring medication to include multiple inhalers
• Patients may not be receiving any other investigational agents (except with permission of the Lead Principal Investigator)
• Pregnant or are nursing
• History of autoimmune disease (patients with vitiligo not excluded)
• HIV positive
• Previous or concomitant malignancies at other sites, except effectively treated non- melanoma skin cancers or carcinoma in situ of the cervix or effectively treated malignancy that has been in remission for over 5 years and highly likely to have been cured
• Other concurrent severe medical problems, unrelated to the malignancy, that would significantly limit full compliance with the study or expose the patient to unacceptable risk
• Uncontrolled congestive heart failure or hypertension, unstable heart disease (coronary artery disease or myocardial infarction) or uncontrolled arrhythmia at the time of enrollment
• Psychiatric, addictive, or any disorder which compromises ability to give truly informed consent for participation in this study or adequate compliance

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Cancer Insight, LLC

INDUSTRY

Sponsor Role: lead

Responsible Party

George E. Peoples

CEO/Founder

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

George E Peoples, MD

Role: PRINCIPAL_INVESTIGATOR

Cancer Insight

Other Identifiers

C.2008.146

Identifier Type: -

Identifier Source: org_study_id