Heart Rate Variability and Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients
NCT ID: NCT02996539
Last Updated: 2016-12-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
392 participants
OBSERVATIONAL
2013-02-28
2015-04-30
Brief Summary
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The present study investigated an association between heart rate variability (HRV) parameters and diabetic kidney disease (DKD) in Chinese type 2 diabetes mellitus (T2DM) patients, specifically through time and frequency domain analyses of HRV and urine albumin creatinine ratio (UACR) or estimated glomerular filtration rate (eGFR).
Detailed Description
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Conditions
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Study Design
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CASE_ONLY
Study Groups
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Type 2 diabetes
With Clinical examination and laboratory measurements
Clinical examination and laboratory measurements
Subjects were interviewed by a physician regarding their medical history, history of hypoglycemic attacks, smoking status, and alcohol consumption. Concentrations of blood urea nitrogen (BUN) and serum creatinine (SCr) were analyzed by the urease-ultraviolet rate method and picric acid method, respectively. Serum uric acid was determined using the enzymatic colorimetric method. Serum hemoglobin A1c (HbA1c) was measured by liquid enzymatic assay. Urine albumin and urine creatinine were found through immune turbidimetric analysis and the enzymatic method, respectively.
Interventions
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Clinical examination and laboratory measurements
Subjects were interviewed by a physician regarding their medical history, history of hypoglycemic attacks, smoking status, and alcohol consumption. Concentrations of blood urea nitrogen (BUN) and serum creatinine (SCr) were analyzed by the urease-ultraviolet rate method and picric acid method, respectively. Serum uric acid was determined using the enzymatic colorimetric method. Serum hemoglobin A1c (HbA1c) was measured by liquid enzymatic assay. Urine albumin and urine creatinine were found through immune turbidimetric analysis and the enzymatic method, respectively.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Adult patients has had consecutively undergone 24-hour Holter monitoring for heart rate variability analysis
Exclusion Criteria
* Foot ulcer
* Severe acute or chronic infection
* Chronic liver disease
* Dialysis or renal transplantation
* The presence of any serious concomitant disease affecting life expectancy were not eligible for the study.
18 Years
80 Years
ALL
No
Sponsors
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Shi wei, MM
OTHER
Responsible Party
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Shi wei, MM
Director
Principal Investigators
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Xiaolei Chen, MM
Role: STUDY_CHAIR
Kunming first people's hospital
Locations
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Internal medicine department, Kunming First People's Hospital
Kunming, Yunnan, China
Countries
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References
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Tuttle KR, Bakris GL, Bilous RW, Chiang JL, de Boer IH, Goldstein-Fuchs J, Hirsch IB, Kalantar-Zadeh K, Narva AS, Navaneethan SD, Neumiller JJ, Patel UD, Ratner RE, Whaley-Connell AT, Molitch ME. Diabetic kidney disease: a report from an ADA Consensus Conference. Diabetes Care. 2014 Oct;37(10):2864-83. doi: 10.2337/dc14-1296.
Related Links
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test link
Other Identifiers
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FirstPHKunming
Identifier Type: -
Identifier Source: org_study_id