Tumor Characteristics, Pre-transplant Treatments and Immunosuppression After Liver Transplantation for Hepatocellular Carcinoma

NCT ID: NCT02995096

Last Updated: 2019-04-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

23124 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2019-03-31

Brief Summary

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Recurrence after liver transplantation for hepatocellular carcinoma (HCC) represents an important cause of mortality for this surgical population. In addition to tumor characteristics, It has been suggested that pre-treatment and sirolimus-based immunosuppression may affect recurrence and survival. With data from the European Liver Transplant Registry (ELTR) database, the aim of this study is to investigate the impact of tumor characteristics, pre-transplant treatment and immunosuppression regimens on survival after liver transplantation for HCC.

Detailed Description

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Conditions

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Liver Transplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Pre-treatment

Non-transplantation pre-treatments prior to transplantation (e.g. radiofrequency ablation, transcatheter arterial chemoembolization)

Intervention Type PROCEDURE

Sirolimus based immunosuppression

Immunosuppression regimens containing Sirolimus

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Hepatocellular carcinoma within transplantation criteria

Exclusion Criteria

* Disseminated disease
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Hans-Christian Pommergaard, MD, PhD

Resident

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hans-Christian Pommergaard, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery and Transplantion, Rigshospitalet, Denmark

Other Identifiers

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There is no unique protocol ID

Identifier Type: -

Identifier Source: org_study_id

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