DASH-Sodium Trial in Adolescents

NCT ID: NCT02993458

Last Updated: 2017-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

79 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2017-10-18

Brief Summary

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The Camp DASH study trial will compare the effect of two dietary patterns and two levels of sodium intake on blood pressure and blood lipids in adolescents in the upper third of distribution for blood pressure. The two dietary patterns are based on the Dietary Approaches to Stop Hypertension (DASH) trial in adults.

Detailed Description

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The Camp DASH study is a controlled trial. the aim of which is to compare the effect of two dietary patterns and two levels of sodium intake on blood pressure and blood lipids in adolescents in the upper third of distribution for blood pressure. The study also assesses whether influences on blood pressure and blood lipids of dietary interventions vary according to sex, race/ethnic groups, baseline levels, and other personal characteristics. The proposed dietary interventions of DASH dietary patterns and sodium reduction have been shown to be effective in lowering blood pressure in adults. The two dietary patterns are based on the Dietary Approaches to Stop Hypertension (DASH) trial in adults. They are a Usual diet typical of what many American adolescents eat, and a DASH-type diet. The DASH diet is rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat compared to the Usual diet. The two sodium levels are High reflecting current US consumption and Low reflecting current recommended intake levels. Weight will be held constant by adjusting energy intake. The study participants will live in a residence hall on the Purdue campus where all food and beverages will be provided, and meals and snacks will be supervised.

Conditions

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Blood High Pressure

Keywords

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dietary patterns blood pressure adolescents dietary sodium

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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DASH diet-Low Na diet

DASH style diet, low sodium (1500 mg/d).

Group Type EXPERIMENTAL

DASH diet

Intervention Type OTHER

DASH style diet rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat

Low Na diet

Intervention Type OTHER

Sodium intake of 1500 mg/d (65 mmol, or 0.75 mg/Kcal/d), representing the Adequate Intake recommended by the Institute of Medicine.

DASH diet-High Na diet

DASH style diet, high sodium (3500 mg/d).

Group Type ACTIVE_COMPARATOR

DASH diet

Intervention Type OTHER

DASH style diet rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat

High Na diet

Intervention Type OTHER

Sodium intake of 3500 mg/d (152 mmol, or 1.73 mg/Kcal/d, representing the highest sodium intake used for adults in the DASH Sodium trial.

Usual diet-Low Na diet

Diet reflecting typical dietary pattern of American adolescents, low sodium (1500 mg/d).

Group Type ACTIVE_COMPARATOR

Low Na diet

Intervention Type OTHER

Sodium intake of 1500 mg/d (65 mmol, or 0.75 mg/Kcal/d), representing the Adequate Intake recommended by the Institute of Medicine.

Usual Diet

Intervention Type OTHER

The usual diet will include foods that provide the majority of energy for adolescents in the U.S., i.e. grain based desserts, pizza, sugary drinks,pasta, chicken, and chicken mixed dishes.

Usual diet-High Na diet

Diet reflecting typical dietary pattern of American adolescents, high sodium (3500 mg/d).

Group Type ACTIVE_COMPARATOR

High Na diet

Intervention Type OTHER

Sodium intake of 3500 mg/d (152 mmol, or 1.73 mg/Kcal/d, representing the highest sodium intake used for adults in the DASH Sodium trial.

Usual Diet

Intervention Type OTHER

The usual diet will include foods that provide the majority of energy for adolescents in the U.S., i.e. grain based desserts, pizza, sugary drinks,pasta, chicken, and chicken mixed dishes.

Interventions

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DASH diet

DASH style diet rich in fruits, vegetables, and low-fat dairy foods and low in saturated fat and total fat

Intervention Type OTHER

Low Na diet

Sodium intake of 1500 mg/d (65 mmol, or 0.75 mg/Kcal/d), representing the Adequate Intake recommended by the Institute of Medicine.

Intervention Type OTHER

High Na diet

Sodium intake of 3500 mg/d (152 mmol, or 1.73 mg/Kcal/d, representing the highest sodium intake used for adults in the DASH Sodium trial.

Intervention Type OTHER

Usual Diet

The usual diet will include foods that provide the majority of energy for adolescents in the U.S., i.e. grain based desserts, pizza, sugary drinks,pasta, chicken, and chicken mixed dishes.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* White, black, Hispanic, and Asian
* SBP in the upper one-third of the distribution for their given sex, age, and height

Exclusion Criteria

* Pre-existing lipid disorders, abnormal liver or kidney function
* Taking medications that alter mineral absorption or metabolism, affect blood pressure or lipids
* If subjects are taking dietary supplements and refuse to discontinue them 2 months prior to the study.
* Taking non-prescription illegal drugs, smoke, or drink alcohol
* Pregnancy
* Carry an epi pen for food-related allergies
Minimum Eligible Age

11 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centers for Disease Control and Prevention

FED

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role collaborator

Indiana University School of Medicine

OTHER

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

Purdue University

OTHER

Sponsor Role lead

Responsible Party

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Berdine Martin

Senior Research Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Connie M Weaver, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Nutrition Science, Purdue University

Berdine R Martin, PhD

Role: STUDY_DIRECTOR

Department of Nutrition Science, Purdue University

Locations

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Department of Pediatrics, IU School of Medicine

Indianapolis, Indiana, United States

Site Status

Department of Nutrition Science, Purdue University

West Lafayette, Indiana, United States

Site Status

Countries

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United States

References

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Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24. doi: 10.1056/NEJM199704173361601.

Reference Type BACKGROUND
PMID: 9099655 (View on PubMed)

Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998 Jun 4;338(23):1650-6. doi: 10.1056/NEJM199806043382302.

Reference Type BACKGROUND
PMID: 9614255 (View on PubMed)

Chen X, Wang Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation. 2008 Jun 24;117(25):3171-80. doi: 10.1161/CIRCULATIONAHA.107.730366. Epub 2008 Jun 16.

Reference Type BACKGROUND
PMID: 18559702 (View on PubMed)

Couch SC, Saelens BE, Levin L, Dart K, Falciglia G, Daniels SR. The efficacy of a clinic-based behavioral nutrition intervention emphasizing a DASH-type diet for adolescents with elevated blood pressure. J Pediatr. 2008 Apr;152(4):494-501. doi: 10.1016/j.jpeds.2007.09.022. Epub 2007 Nov 5.

Reference Type BACKGROUND
PMID: 18346503 (View on PubMed)

Food and Nutrition Board, Institute of Medicine. 'Sodium and chloride', Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, D.C.: National Academies Press; 2005. 269-423.

Reference Type BACKGROUND

Palacios C, Wigertz K, Martin BR, Braun M, Pratt JH, Peacock M, Weaver CM. Racial differences in potassium homeostasis in response to differences in dietary sodium in girls. Am J Clin Nutr. 2010 Mar;91(3):597-603. doi: 10.3945/ajcn.2009.28400. Epub 2009 Dec 9.

Reference Type BACKGROUND
PMID: 20007307 (View on PubMed)

Palacios C, Wigertz K, Braun M, Martin BR, McCabe GP, McCabe L, Pratt JH, Peacock M, Weaver CM. Magnesium retention from metabolic-balance studies in female adolescents: impact of race, dietary salt, and calcium. Am J Clin Nutr. 2013 May;97(5):1014-9. doi: 10.3945/ajcn.112.039867. Epub 2013 Apr 3.

Reference Type BACKGROUND
PMID: 23553157 (View on PubMed)

Palacios C, Wigertz K, Martin BR, Jackman L, Pratt JH, Peacock M, McCabe G, Weaver CM. Sodium retention in black and white female adolescents in response to salt intake. J Clin Endocrinol Metab. 2004 Apr;89(4):1858-63. doi: 10.1210/jc.2003-031446.

Reference Type BACKGROUND
PMID: 15070956 (View on PubMed)

Rakova N, Juttner K, Dahlmann A, Schroder A, Linz P, Kopp C, Rauh M, Goller U, Beck L, Agureev A, Vassilieva G, Lenkova L, Johannes B, Wabel P, Moissl U, Vienken J, Gerzer R, Eckardt KU, Muller DN, Kirsch K, Morukov B, Luft FC, Titze J. Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance. Cell Metab. 2013 Jan 8;17(1):125-31. doi: 10.1016/j.cmet.2012.11.013.

Reference Type BACKGROUND
PMID: 23312287 (View on PubMed)

Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER 3rd, Simons-Morton DG, Karanja N, Lin PH; DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. 2001 Jan 4;344(1):3-10. doi: 10.1056/NEJM200101043440101.

Reference Type BACKGROUND
PMID: 11136953 (View on PubMed)

Van Horn L, Obarzanek E, Barton BA, Stevens VJ, Kwiterovich PO Jr, Lasser NL, Robson AM, Franklin FA Jr, Lauer RM, Kimm SY, Dorgan JF, Greenlick MR. A summary of results of the Dietary Intervention Study in Children (DISC): lessons learned. Prog Cardiovasc Nurs. 2003 Winter;18(1):28-41. doi: 10.1111/j.0889-7204.2003.01007.x.

Reference Type BACKGROUND
PMID: 12624570 (View on PubMed)

Weaver CM, Martin BR, McCabe GP, McCabe LD, Woodward M, Anderson CA, Appel LJ. Individual variation in urinary sodium excretion among adolescent girls on a fixed intake. J Hypertens. 2016 Jul;34(7):1290-7. doi: 10.1097/HJH.0000000000000960.

Reference Type BACKGROUND
PMID: 27176144 (View on PubMed)

Other Identifiers

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1U01HL128834

Identifier Type: NIH

Identifier Source: secondary_id

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1U01HL128834-01A1

Identifier Type: NIH

Identifier Source: org_study_id

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