Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
NCT ID: NCT02993406
Last Updated: 2024-01-03
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE3
13970 participants
INTERVENTIONAL
2016-12-22
2022-11-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Bempedoic Acid 180 mg
Bempedoic acid 180 mg tablet taken orally, once daily.
Bempedoic acid 180 mg tablet
Patients take bempedoic acid 180 mg tablet orally once daily
Placebo Comparator
Matching placebo tablet taken orally, once daily
Matching placebo tablet
Patients take matching placebo tablet orally once daily
Interventions
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Bempedoic acid 180 mg tablet
Patients take bempedoic acid 180 mg tablet orally once daily
Matching placebo tablet
Patients take matching placebo tablet orally once daily
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* History of, or at high risk for, cardiovascular disease (CVD) including coronary artery disease, symptomatic peripheral arterial disease, cerebrovascular atherosclerotic disease, or at high risk for a cardiovascular event
* Participant-reported SI due to an adverse safety effect that started or increased during statin therapy and resolved or improved when statin therapy was discontinued resulting in an inability to tolerate:
* 2 or more statins at any dose, or
* 1 statin at any dose and unwilling to attempt a second statin or advised by a physician to not attempt a second statin.
Please note that participants currently tolerating very low dose statin therapy (an average daily dose of rosuvastatin \<5 mg, atorvastatin \<10 mg, simvastatin \<10 mg, lovastatin \<20 mg, pravastatin \<40 mg, fluvastatin \<40 mg, or pitavastatin \<2 mg) are considered to be intolerant to that low dose statin. Patients may continue taking very low dose statin therapy throughout the study provided that it is stable (used for at least 4 weeks prior to screening) and well tolerated.
* Written confirmation by both participant and investigator that the participant is statin intolerant as defined above, aware of the benefit of statin use to reduce the risk of MACE including death, and also aware that many other participants who are unable to tolerate a statin are able to tolerate a different statin or dose.
* Men and nonpregnant, nonlactating women
* Fasting blood LDL-cholesterol ≥ 100 (2.6 mmol/L) at screening
Exclusion Criteria
* Recent (within 90 days of screening) history of major cardiovascular events, transient ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia
* History of severe heart failure
* Uncontrolled hypertension or uncontrolled diabetes
18 Years
85 Years
ALL
No
Sponsors
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The Cleveland Clinic
OTHER
Esperion Therapeutics, Inc.
INDUSTRY
Responsible Party
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Locations
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Soham, Cambridgeshire, United Kingdom
Fowey, Cornwall, United Kingdom
Hayle, Cornwall, United Kingdom
Torpoint, Cornwall, United Kingdom
Exmouth, Devon, United Kingdom
Birmingham, Alabama, United States
Birmingham, Alabama, United States
Huntsville, Alabama, United States
Mobile, Alabama, United States
Mobile, Alabama, United States
Pell City, Alabama, United States
Tuscumbia, Alabama, United States
Chandler, Arizona, United States
Cottonwood, Arizona, United States
Fountain Hills, Arizona, United States
Gilbert, Arizona, United States
Glendale, Arizona, United States
Glendale, Arizona, United States
Mesa, Arizona, United States
Phoenix, Arizona, United States
Phoenix, Arizona, United States
Tucson, Arizona, United States
Tucson, Arizona, United States
Beverly Hills, California, United States
Carlsbad, California, United States
Huntington Beach, California, United States
Lincoln, California, United States
Long Beach, California, United States
Long Beach, California, United States
Northridge, California, United States
Oceanside, California, United States
Rancho Cucamonga, California, United States
San Diego, California, United States
Santa Ana, California, United States
Santa Rosa, California, United States
Torrance, California, United States
Vista, California, United States
Aurora, Colorado, United States
Colorado Springs, Colorado, United States
Colorado Springs, Colorado, United States
Golden, Colorado, United States
Littleton, Colorado, United States
Loveland, Colorado, United States
Hamden, Connecticut, United States
Hartford, Connecticut, United States
North Haven, Connecticut, United States
Stamford, Connecticut, United States
Boca Raton, Florida, United States
Boynton Beach, Florida, United States
Boynton Beach, Florida, United States
Bradenton, Florida, United States
Clearwater, Florida, United States
Crystal River, Florida, United States
Fleming Island, Florida, United States
Fort Lauderdale, Florida, United States
Fort Lauderdale, Florida, United States
Greenacres City, Florida, United States
Hialeah, Florida, United States
Hialeah, Florida, United States
Inverness, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jupiter, Florida, United States
Lake Worth, Florida, United States
Largo, Florida, United States
Largo, Florida, United States
Melbourne, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami Lakes, Florida, United States
Naples, Florida, United States
New Port Richey, Florida, United States
North Miami Beach, Florida, United States
Ocala, Florida, United States
Orlando, Florida, United States
Ormond Beach, Florida, United States
Pembroke Pines, Florida, United States
Pembroke Pines, Florida, United States
Pembroke Pines, Florida, United States
Pinellas Park, Florida, United States
Ponte Vedra, Florida, United States
Port Charlotte, Florida, United States
Safety Harbor, Florida, United States
St. Petersburg, Florida, United States
Tampa, Florida, United States
Wellington, Florida, United States
Atlanta, Georgia, United States
Columbus, Georgia, United States
Covington, Georgia, United States
Cumming, Georgia, United States
Dunwoody, Georgia, United States
Gainesville, Georgia, United States
Macon, Georgia, United States
Savannah, Georgia, United States
Tucker, Georgia, United States
Woodstock, Georgia, United States
Meridian, Idaho, United States
Champaign, Illinois, United States
Chicago, Illinois, United States
Gurnee, Illinois, United States
Jerseyville, Illinois, United States
Olympia Fields, Illinois, United States
Rock Island, Illinois, United States
Rockford, Illinois, United States
Anderson, Indiana, United States
Elkhart, Indiana, United States
Evansville, Indiana, United States
Evansville, Indiana, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Munster, Indiana, United States
Richmond, Indiana, United States
Council Bluffs, Iowa, United States
Iowa City, Iowa, United States
Waterloo, Iowa, United States
West Des Moines, Iowa, United States
Hutchinson, Kansas, United States
Kansas City, Kansas, United States
Wichita, Kansas, United States
Elizabethtown, Kentucky, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Paducah, Kentucky, United States
Eunice, Louisiana, United States
Lake Charles, Louisiana, United States
New Orleans, Louisiana, United States
New Orleans, Louisiana, United States
West Monroe, Louisiana, United States
Annapolis, Maryland, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Columbia, Maryland, United States
Rockville, Maryland, United States
Salisbury, Maryland, United States
Towson, Maryland, United States
Haverhill, Massachusetts, United States
Hyannis, Massachusetts, United States
Buckley, Michigan, United States
Cadillac, Michigan, United States
Caro, Michigan, United States
Grand Blanc, Michigan, United States
Grand Rapids, Michigan, United States
Kalamazoo, Michigan, United States
Lansing, Michigan, United States
Lansing, Michigan, United States
Mount Clemens, Michigan, United States
Petoskey, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
Troy, Michigan, United States
Minneapolis, Minnesota, United States
Richfield, Minnesota, United States
Saint Cloud, Minnesota, United States
Saint Paul, Minnesota, United States
Saint Paul, Minnesota, United States
Tupelo, Mississippi, United States
Bridgeton, Missouri, United States
St Louis, Missouri, United States
St Louis, Missouri, United States
Kalispell, Montana, United States
Fremont, Nebraska, United States
Lincoln, Nebraska, United States
Omaha, Nebraska, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Nashua, New Hampshire, United States
Bridgeton, New Jersey, United States
Bridgewater, New Jersey, United States
Flemington, New Jersey, United States
Haddon, New Jersey, United States
Linden, New Jersey, United States
Sewell, New Jersey, United States
Teaneck, New Jersey, United States
Albany, New York, United States
Binghamton, New York, United States
Bronxville, New York, United States
Buffalo, New York, United States
Endwell, New York, United States
Jackson Heights, New York, United States
Jamaica, New York, United States
Manhasset, New York, United States
New Windsor, New York, United States
New York, New York, United States
New York, New York, United States
Poughkeepsie, New York, United States
Saratoga Springs, New York, United States
Southampton, New York, United States
Asheboro, North Carolina, United States
Burlington, North Carolina, United States
Cary, North Carolina, United States
Cary, North Carolina, United States
Charlotte, North Carolina, United States
Greensboro, North Carolina, United States
Greensboro, North Carolina, United States
Greensboro, North Carolina, United States
Hickory, North Carolina, United States
Lenoir, North Carolina, United States
Mooresville, North Carolina, United States
Morehead City, North Carolina, United States
Raleigh, North Carolina, United States
Rocky Mount, North Carolina, United States
Rocky Mount, North Carolina, United States
Sanford, North Carolina, United States
Wilmington, North Carolina, United States
Winston-Salem, North Carolina, United States
Fargo, North Dakota, United States
Akron, Ohio, United States
Akron, Ohio, United States
Canton, Ohio, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Cleveland, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Dayton, Ohio, United States
Franklin, Ohio, United States
Marion, Ohio, United States
Maumee, Ohio, United States
Middleburg Heights, Ohio, United States
Norman, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Tulsa, Oklahoma, United States
Abington, Pennsylvania, United States
Beaver, Pennsylvania, United States
Camp Hill, Pennsylvania, United States
Johnstown, Pennsylvania, United States
McMurray, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Smithfield, Pennsylvania, United States
Uniontown, Pennsylvania, United States
York, Pennsylvania, United States
Cumberland, Rhode Island, United States
Providence, Rhode Island, United States
Anderson, South Carolina, United States
Anderson, South Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Greer, South Carolina, United States
Little River, South Carolina, United States
Old Point Station, South Carolina, United States
Summerville, South Carolina, United States
Rapid City, South Dakota, United States
Rapid City, South Dakota, United States
Fayetteville, Tennessee, United States
Greeneville, Tennessee, United States
Jackson, Tennessee, United States
Knoxville, Tennessee, United States
Allen, Texas, United States
Amarillo, Texas, United States
Seton Heart Institute
Austin, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
DeSoto, Texas, United States
Fort Worth, Texas, United States
Fort Worth, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Katy, Texas, United States
Kerrville, Texas, United States
Lubbock, Texas, United States
McKinney, Texas, United States
Odessa, Texas, United States
Pearland, Texas, United States
Plano, Texas, United States
Plano, Texas, United States
San Angelo, Texas, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
Schertz, Texas, United States
Sugar Land, Texas, United States
Tomball, Texas, United States
Tyler, Texas, United States
Victoria, Texas, United States
Farmington, Utah, United States
Layton, Utah, United States
Murray, Utah, United States
Orem, Utah, United States
Burke, Virginia, United States
Charlottesville, Virginia, United States
Danville, Virginia, United States
Falls Church, Virginia, United States
Hampton, Virginia, United States
Norfolk, Virginia, United States
Roanoke, Virginia, United States
Suffolk, Virginia, United States
Woodbridge, Virginia, United States
Bellevue, Washington, United States
Green Bay, Wisconsin, United States
Kenosha, Wisconsin, United States
La Crosse, Wisconsin, United States
Madison, Wisconsin, United States
Bahía Blanca, Buenos Aires, Argentina
Bahía Blanca, Buenos Aires, Argentina
Bahía Blanca, Buenos Aires, Argentina
Berazategui, Buenos Aires, Argentina
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Coronel Suárez, Buenos Aires, Argentina
Haedo, Buenos Aires, Argentina
La Plata, Buenos Aires, Argentina
Mar del Plata, Buenos Aires, Argentina
Mar del Plata, Buenos Aires, Argentina
Mar del Plata, Buenos Aires, Argentina
Mar del Plata, Buenos Aires, Argentina
Morón, Buenos Aires, Argentina
San Fernando, Buenos Aires, Argentina
San Martín, Buenos Aires, Argentina
Vicente López, Buenos Aires, Argentina
Zárate, Buenos Aires, Argentina
Villa Luro, Ciudad Autonoma Buenos Aires, Argentina
Caba, Ciudad Autonoma, Argentina
Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, Argentina
Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, Argentina
Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, Argentina
Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, Argentina
Ciudad Autónoma de Buenos Aire, Ciudad Autonoma, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
San Vicente, Córdoba Province, Argentina
Godoy Cruz, Mendoza Province, Argentina
San Rafael, Mendoza Province, Argentina
Temperley, Partido De Lomas De Zamora, Argentina
Rosario, Santa Fe Province, Argentina
Rosario, Santa Fe Province, Argentina
Rosario, Santa Fe Province, Argentina
Rosario, Santa Fe Province, Argentina
Rosario, Sante Fe, Argentina
San Miguel de Tucumán, Tucumán Province, Argentina
San Miguel de Tucumán, Tucumán Province, Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Corrientes, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
Córdoba, , Argentina
La Plata, , Argentina
La Plata, , Argentina
Lanús, , Argentina
Morón, , Argentina
Pilar, , Argentina
Quilmes, , Argentina
Ramos Mejía, , Argentina
Rosario, , Argentina
Rosario, , Argentina
Salta, , Argentina
San Lorenzo, , Argentina
San Miguel de Tucumán, , Argentina
San Miguel de Tucumán, , Argentina
Santa Fe, , Argentina
Santa Fe, , Argentina
Adamstown, New South Wales, Australia
Camperdown, New South Wales, Australia
Gosford, New South Wales, Australia
Liverpool, New South Wales, Australia
Merewether, New South Wales, Australia
Tumbi Vmbi, New South Wales, Australia
Wollongong, New South Wales, Australia
Auchenflower, Queensland, Australia
Bundaberg, Queensland, Australia
Chermside, Queensland, Australia
Milton, Queensland, Australia
Sherwood, Queensland, Australia
Sippy Downs, Queensland, Australia
Woolloongabba, Queensland, Australia
Adelaide, South Australia, Australia
Ashford, South Australia, Australia
Fullarton, South Australia, Australia
Hobart, Tasmania, Australia
Ballarat, Victoria, Australia
Box Hill, Victoria, Australia
Clayton, Victoria, Australia
Fitzroy, Victoria, Australia
Frankston, Victoria, Australia
Langwarrin, Victoria, Australia
Melbourne, Victoria, Australia
Mildura, Victoria, Australia
Joondalup, Western Australia, Australia
Murdoch, Western Australia, Australia
Nedlands, Western Australia, Australia
Perth, Western Australia, Australia
Subiaco, Western Australia, Australia
Feldkirch, , Austria
Graz, , Austria
Innsbruck, , Austria
Linz, , Austria
Linz, , Austria
Vienna, , Austria
Vienna, , Austria
Vienna, , Austria
Vienna, , Austria
Vienna, , Austria
Wiener Neustadt, , Austria
Aalst, , Belgium
Antwerp, , Belgium
Antwerp, , Belgium
Brasschaat, , Belgium
Bruges, , Belgium
Brussels, , Belgium
Brussels, , Belgium
De Pinte, , Belgium
Dendermonde, , Belgium
Edegem, , Belgium
Genk, , Belgium
Ghent, , Belgium
Halen, , Belgium
Liège, , Belgium
Mechelen, , Belgium
Merksem, , Belgium
Mons, , Belgium
Tienen, , Belgium
Turnhout, , Belgium
Wetteren, , Belgium
Yvoir, , Belgium
Fortaleza, Ceará, Brazil
Fortaleza, Ceará, Brazil
Fortaleza, Ceará, Brazil
Fortaleza, Ceará, Brazil
Vitória, Espírito Santo, Brazil
Salvador, Estado de Bahia, Brazil
Brasília, Federal District, Brazil
Brasília, Federal District, Brazil
Brasília, Federal District, Brazil
Goiânia, Goiás, Brazil
Goiânia, Goiás, Brazil
Campo Grande, Mato Grosso do Sul, Brazil
Belo Horizonte, Minas Gerais, Brazil
Belo Horizonte, Minas Gerais, Brazil
Belo Horizonte, Minas Gerais, Brazil
Uberlândia, Minas Gerais, Brazil
Curitiba, Paraná, Brazil
Curitiba, Paraná, Brazil
Curitiba, Paraná, Brazil
Curitiba, Paraná, Brazil
Belém, Pará, Brazil
Recife, Pernambuco, Brazil
Boa Vista, Recife, Brazil
Natal, Rio Grande do Norte, Brazil
Passo Fundo, Rio Grande do Sul, Brazil
Porto Alegre, Rio Grande do Sul, Brazil
Porto Alegre, Rio Grande do Sul, Brazil
Porto Alegre, Rio Grande do Sul, Brazil
Porto Alegre, Rio Grande do Sul, Brazil
Santa Maria, Rio Grande do Sul, Brazil
Caxias do Sul, Rio Grande Du Sul, Brazil
Porto Alegre, Rio Grande Du Sul, Brazil
Balneário Camboriú, Santa Catarina, Brazil
Blumenau, Santa Catarina, Brazil
São Paulo, Sau Paulo, Brazil
Campinas, São Paulo, Brazil
Campinas, São Paulo, Brazil
Campinas, São Paulo, Brazil
Cotia, São Paulo, Brazil
Jaú, São Paulo, Brazil
Marília, São Paulo, Brazil
Paraíso, São Paulo, Brazil
Santo André, São Paulo, Brazil
Santo André, São Paulo, Brazil
Santo André, São Paulo, Brazil
São José do Rio Preto, São Paulo, Brazil
São José do Rio Preto, São Paulo, Brazil
São José dos Campos, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
São Paulo, São Paulo, Brazil
Tatuí, São Paulo, Brazil
Votuporanga, São Paulo, Brazil
Bela Vista, , Brazil
Belo Horizonte, , Brazil
Belo Horizonte, , Brazil
Belo Horizonte, , Brazil
Bento Gonçalves, , Brazil
Brasília, , Brazil
Curitiba, , Brazil
Curitiba, , Brazil
Curitiba, , Brazil
Goiânia, , Brazil
Joinville, , Brazil
Maceió, , Brazil
Maringá, , Brazil
Marília, , Brazil
Porto Alegre, , Brazil
Porto Alegre, , Brazil
Rio de Janeiro, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Santa Maria, , Brazil
São José, , Brazil
São Luís, , Brazil
São Paulo, , Brazil
São Paulo, , Brazil
Blagoevgrad, , Bulgaria
Byala, , Bulgaria
Dimitrovgrad, , Bulgaria
Haskovo, , Bulgaria
Pazardzhik, , Bulgaria
Pernik, , Bulgaria
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Plovdiv, , Bulgaria
Rousse, , Bulgaria
Rousse, , Bulgaria
Sandanski, , Bulgaria
Sliven, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Stara Zagora, , Bulgaria
Stara Zagora, , Bulgaria
Varna, , Bulgaria
Varna, , Bulgaria
Varna, , Bulgaria
Veliko Tarnovo, , Bulgaria
Yambol, , Bulgaria
Victoria, British Columbia, Canada
Mount Pearl, Newfoundland and Labrador, Canada
Brampton, Ontario, Canada
Brampton, Ontario, Canada
Cambridge, Ontario, Canada
Cambridge, Ontario, Canada
Greater Sudbury, Ontario, Canada
London, Ontario, Canada
Newmarket, Ontario, Canada
Oakville, Ontario, Canada
Peterborough, Ontario, Canada
Sarnia, Ontario, Canada
Toronto, Ontario, Canada
Chicoutimi, Quebec, Canada
Longueuil, Quebec, Canada
Longueuil, Quebec, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Pointe-Claire, Quebec, Canada
Saint-Georges, Quebec, Canada
Saint-Jean-sur-Richelieu, Quebec, Canada
Saint-Jérôme, Quebec, Canada
Victoriaville, Quebec, Canada
Québec, , Canada
Québec, , Canada
San Bernardo, , Chile
Santiago, , Chile
Santiago, , Chile
Santiago, , Chile
Santiago, , Chile
Santiago, , Chile
Santiago, , Chile
Temuco, , Chile
Viña del Mar, , Chile
Barranquilla, , Colombia
Barranquilla, , Colombia
Barranquilla, , Colombia
Bogotá, , Colombia
Bogotá, , Colombia
Bogotá, , Colombia
Bogotá, , Colombia
Bogotá, , Colombia
Bucaramanga, , Colombia
Bucaramanga, , Colombia
Cali, , Colombia
Cali, , Colombia
Cartagena, , Colombia
Cartagena, , Colombia
Espinal, , Colombia
Ibagué, , Colombia
Manizales, , Colombia
Medellín, , Colombia
Medellín, , Colombia
Pereira, , Colombia
San Gil, , Colombia
Zipaquirá, , Colombia
Čakovec, , Croatia
Dubrovnik, , Croatia
Koprivnica, , Croatia
Krapinske Toplice, , Croatia
Opatija, , Croatia
Osijek, , Croatia
Rijeka, , Croatia
Slavonski Brod, , Croatia
Varaždin, , Croatia
Virovitica, , Croatia
Zabok, , Croatia
Zadar, , Croatia
Zagreb, , Croatia
Benátky nad Jizerou, , Czechia
Beroun, , Czechia
Brandýs nad Labem, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Brno, , Czechia
Broumov, , Czechia
Choceň, , Czechia
Chrudim, , Czechia
Frýdek-Místek, , Czechia
Havířov, , Czechia
Havlíčkův Brod, , Czechia
Hodonín, , Czechia
Hradec Králové, , Czechia
Hradec Králové, , Czechia
Kolín, , Czechia
Náchod, , Czechia
Olomouc, , Czechia
Ostrava, , Czechia
Pardubice, , Czechia
Prague, , Czechia
Prague, , Czechia
Prague, , Czechia
Prague, , Czechia
Prague, , Czechia
Prague, , Czechia
Prague, , Czechia
Praha 4 - Krc, , Czechia
Přerov, , Czechia
Slaný, , Czechia
Teplice, , Czechia
Trutnov, , Czechia
Uherské Hradiště, , Czechia
Aalborg, , Denmark
Aalborg, , Denmark
Århus N, , Denmark
Ballerup Municipality, , Denmark
Copenhagen NV, , Denmark
Esbjerg, , Denmark
Glostrup Municipality, , Denmark
Hellerup, , Denmark
Holbæk, , Denmark
Nykøbing Falster, , Denmark
Vejle, , Denmark
Viborg, , Denmark
Tallinn, , Estonia
Tallinn, , Estonia
Tallinn, , Estonia
Tallinn, , Estonia
Bad Krozingen, Baden-Wurttemberg, Germany
Dresden, Baden-Wurttemberg, Germany
Heidelberg, Baden-Wurttemberg, Germany
Munich, Bavaria, Germany
Wallerfing, Bavaria, Germany
Bad Homburg, Hesse, Germany
Frankfurt am Main, Hesse, Germany
Frankfurt am Main, Hesse, Germany
Frankfurt am Main, Hesse, Germany
Kassel, Hesse, Germany
Mainz, Hesse, Germany
Rodgau, Hesse, Germany
Schwerin, Mecklenburg-Vorpommern, Germany
Bielefeld, North Rhine-Westphalia, Germany
Bochum, North Rhine-Westphalia, Germany
Cologne, North Rhine-Westphalia, Germany
Cologne, North Rhine-Westphalia, Germany
Dortmund, North Rhine-Westphalia, Germany
Dortmund, North Rhine-Westphalia, Germany
Essen, North Rhine-Westphalia, Germany
Essen, North Rhine-Westphalia, Germany
Goch, North Rhine-Westphalia, Germany
Siegen, North Rhine-Westphalia, Germany
Soest, North Rhine-Westphalia, Germany
Witten, North Rhine-Westphalia, Germany
Mainz, Rhineland-Palatinate, Germany
Altenburg, Saxony, Germany
Böhlen, Saxony, Germany
Dippoldiswalde, Saxony, Germany
Dresden, Saxony, Germany
Dresden, Saxony, Germany
Dresden, Saxony, Germany
Dresden, Saxony, Germany
Leipzig, Saxony, Germany
Leipzig, Saxony, Germany
Markkleeberg, Saxony, Germany
Wermsdorf, Saxony, Germany
Zwenkau, Saxony, Germany
Bad Homburg, , Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Bielefeld, , Germany
Falkensee, , Germany
Frankfurt, , Germany
Hamburg, , Germany
Hamburg, , Germany
Hamburg, , Germany
Hanover, , Germany
Heidelberg, , Germany
Mainz, , Germany
Reinfeld, , Germany
Orosháza, Szentetornya, Hungary
Baja, , Hungary
Balatonfüred, , Hungary
Balatongyörök, , Hungary
Békéscsaba, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Debrecen, , Hungary
Dombóvár, , Hungary
Gyöngyös, , Hungary
Győr, , Hungary
Gyula, , Hungary
Hajdúszoboszló, , Hungary
Kalocsa, , Hungary
Kecskemét, , Hungary
Kiskunhalas, , Hungary
Miskolc, , Hungary
Mosonmagyaróvár, , Hungary
Nagykanizsa, , Hungary
Nyíregyháza, , Hungary
Nyíregyháza, , Hungary
Orosháza, , Hungary
Pécs, , Hungary
Pécs, , Hungary
Polgár, , Hungary
Szekszárd, , Hungary
Szentendre, , Hungary
Szentes, , Hungary
Székesfehérvár, , Hungary
Szombathely, , Hungary
Zalaegerszeg, , Hungary
Hyderabad, Andhra Pradesh, India
Guwahati, Assam, India
Ahmedabad, Gujarat, India
Nadiād, Gujarat, India
Surat, Gujarat, India
Surat, Gujarat, India
Vadodara, Gujarat, India
Faridabad, Haryana, India
Gurgaon, Haryana, India
Bangalore, Karnataka, India
Bangalore, Karnataka, India
Belagavi, Karnataka, India
Bengaluru, Karnataka, India
Hubli, Karnatak, India
Aurangabad, Maharashtra, India
Aurangabad, Maharashtra, India
Nagpur, Maharashtra, India
Nagpur, Maharashtra, India
Nagpur, Maharashtra, India
Nashik, Maharashtra, India
Nashik, Maharashtra, India
Pune, Maharashtra, India
Pune, Maharashtra, India
Pune, Maharashtra, India
New Delhi, National Capital Territory of Delhi, India
New Delhi, National Capital Territory of Delhi, India
New Delhi, National Capital Territory of Delhi, India
Jaipur, Rajasthan, India
Jaipur, Rajasthan, India
Chennai, Tamil Nadu, India
Coimbatore, Tamil Nadu, India
Lucknow, Uttar Pradesh, India
Noida, Uttar Pradesh, India
Kolkata, West Bengal, India
Delhi, , India
Daugavpils, , Latvia
Kuldīga, , Latvia
Ogre, , Latvia
Riga, , Latvia
Riga, , Latvia
Riga, , Latvia
Riga, , Latvia
Tukums, , Latvia
Ventspils, , Latvia
Alytus, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Kaunas, , Lithuania
Klaipėda, , Lithuania
Šiauliai, , Lithuania
Vilnius, , Lithuania
Vilnius, , Lithuania
Tijuana, Baja California Norte, Mexico
Chihuahua City, Chihuahua C.P., Mexico
Monclova, Coahuila, Mexico
Torreón, Coahuila, Mexico
Pachuca, Hidalgo, Mexico
Guadalajara, Jalisco, Mexico
Guadalajara, Jalisco, Mexico
Mexico City, Mexico City, Mexico
Mexico City, Mexico City, Mexico
Mexico City, Mexico City, Mexico
Mexico City, Mexico City, Mexico
Mexico City, Mexico City, Mexico
Monterrey, Nuevo León, Mexico
Querétaro City, Querétaro, Mexico
Culiacán, Sinaloa, Mexico
Culiacán, Sinaloa, Mexico
Mazatlán, Sinaloa, Mexico
Mérida, Yucatán, Mexico
Aguascalientes, , Mexico
Aguascalientes, , Mexico
Aguascalientes, , Mexico
Chihuahua City, , Mexico
Chihuahua City, , Mexico
Chihuahua City, , Mexico
Cuernavaca, , Mexico
Durango, , Mexico
Guadalajara, , Mexico
Guadalajara, , Mexico
Guadalajara, , Mexico
Guadalajara, , Mexico
Juárez, , Mexico
Mexico City, , Mexico
Mexico City, , Mexico
Mexico City, , Mexico
Mexico City, , Mexico
Monterrey, , Mexico
Monterrey, , Mexico
Monterrey, , Mexico
Pachuca, , Mexico
Puerto Vallarta, , Mexico
Querétaro, , Mexico
Tamaulipas, , Mexico
Veracruz, , Mexico
Alkmaar, , Netherlands
Almelo, , Netherlands
Almere Stad, , Netherlands
Amersfoort, , Netherlands
Amstelveen, , Netherlands
Amsterdam, , Netherlands
Amsterdam, , Netherlands
Amsterdam, , Netherlands
Amsterdam, , Netherlands
Amsterdam, , Netherlands
Amsterdam, , Netherlands
Apeldoorn, , Netherlands
Apeldoorn, , Netherlands
Arnhem, , Netherlands
Beverwijk, , Netherlands
Blaricum, , Netherlands
Delft, , Netherlands
Dirksland, , Netherlands
Doetinchem, , Netherlands
Dordrecht, , Netherlands
Ede, , Netherlands
Eindhoven, , Netherlands
Enschede, , Netherlands
Goes, , Netherlands
Gorinchem, , Netherlands
Gouda, , Netherlands
Gouda, , Netherlands
Hardenberg, , Netherlands
Hardenberg, , Netherlands
Harderwijk, , Netherlands
Heerlen, , Netherlands
Helmond, , Netherlands
Hilversum, , Netherlands
Hoogeveen, , Netherlands
Hoogezand, , Netherlands
Hoorn, , Netherlands
Leeuwarden, , Netherlands
Leiden, , Netherlands
Leiderdorp, , Netherlands
Maastricht, , Netherlands
Nijmegen, , Netherlands
Nijmegen, , Netherlands
Purmerend, , Netherlands
Roosendaal, , Netherlands
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Schiedam, , Netherlands
Sneek, , Netherlands
The Hague, , Netherlands
The Hague, , Netherlands
The Hague, , Netherlands
Tiel, , Netherlands
Tilburg, , Netherlands
Utrecht, , Netherlands
Utrecht, , Netherlands
Utrecht, , Netherlands
Venlo, , Netherlands
Zutphen, , Netherlands
Zwijndrecht, , Netherlands
Zwijndrecht, , Netherlands
Zwolle, , Netherlands
Auckland, , New Zealand
Auckland, , New Zealand
Auckland, , New Zealand
Auckland, , New Zealand
Christchurch, , New Zealand
Christchurch, , New Zealand
Grafton, , New Zealand
Hamilton, , New Zealand
Hastings, , New Zealand
New Plymouth, , New Zealand
Papamoa, , New Zealand
Rotorua, , New Zealand
Tauranga, , New Zealand
Tauranga, , New Zealand
Wellington, , New Zealand
Włocławek, Kuyavian-Pomeranian Voivodeship, Poland
Krakow, Lesser Poland Voivodeship, Poland
Tarnów, Lesser Poland Voivodeship, Poland
Legnica, Lower Silesian Voivodeship, Poland
Wroclaw, Lower Silesian Voivodeship, Poland
Wroclaw, Lower Silesian Voivodeship, Poland
Lublin, Lubelski, Poland
Katowice, Silesian Voivodeship, Poland
Katowice, Sląskie, Poland
Katowice, Sląskie, Poland
Ruda Śląska, Sląskie, Poland
Bialystok, , Poland
Brzozów, , Poland
Bydgoszcz, , Poland
Bydgoszcz, , Poland
Chełm, , Poland
Częstochowa, , Poland
Elblag, , Poland
Gdansk, , Poland
Gdansk, , Poland
Gdynia, , Poland
Grodzisk Mazowiecki, , Poland
Katowice, , Poland
Katowice, , Poland
Kielce, , Poland
Krakow, , Poland
Krakow, , Poland
Krakow, , Poland
Legnica, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lodz, , Poland
Lublin, , Poland
Lublin, , Poland
Nałęczów, , Poland
Nowa Sól, , Poland
Nowy Targ, , Poland
Oświęcim, , Poland
Poznan, , Poland
Poznan, , Poland
Poznan, , Poland
Puławy, , Poland
Płock, , Poland
Ruda Śląska, , Poland
Ruda Śląska, , Poland
Rzeszów, , Poland
Rzeszów, , Poland
Rzeszów, , Poland
Siedlce, , Poland
Skierniewice, , Poland
Sopot, , Poland
Staszów, , Poland
Szczecin, , Poland
Szczecin, , Poland
Tarnów, , Poland
Tczew, , Poland
Torun, , Poland
Warsaw, , Poland
Warsaw, , Poland
Warsaw, , Poland
Warsaw, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Wroclaw, , Poland
Włocławek, , Poland
Zamość, , Poland
Piteşti, Argeş, Romania
Baia Mare, Maramureş, Romania
Satu Mare, Satu Mare County, Romania
Timișoara, Timiș County, Romania
Alba Iulia, , Romania
Baia Mare, , Romania
Baia Mare, , Romania
Baloteşti, , Romania
Brasov, , Romania
Brasov, , Romania
Brăila, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Bucharest, , Romania
Călăraşi, , Romania
Cluj-Napoca, , Romania
Craiova, , Romania
Deva, , Romania
Galati, , Romania
Galati, , Romania
Oradea, , Romania
Oradea, , Romania
Oradea, , Romania
Oradea, , Romania
Paşcani, , Romania
Piteşti, , Romania
Ploieşti, , Romania
Satu Mare, , Romania
Târgu Mureş, , Romania
Târgu Mureş, , Romania
Târgu Mureş, , Romania
Târgu Mureş, , Romania
Timișoara, , Romania
Timișoara, , Romania
Timișoara, , Romania
Zalău, , Romania
Barnaul, Altayskiy Kray, Russia
Arkhangelsk, , Russia
Barnaul, , Russia
Chelyabinsk, , Russia
Chelyabinsk, , Russia
Ivanovo, , Russia
Kazan', , Russia
Kemerovo, , Russia
Kemerovo, , Russia
Kemerovo, , Russia
Kirov, , Russia
Kirov, , Russia
Kirovsk, , Russia
Krasnoyarsk, , Russia
Kursk, , Russia
Kursk, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Moscow, , Russia
Nizhny Novgorod, , Russia
Novosibirsk, , Russia
Novosibirsk, , Russia
Novosibirsk, , Russia
Novosibirsk, , Russia
Omsk, , Russia
Omsk, , Russia
Orenburg, , Russia
Perm, , Russia
Rostov-on-Don, , Russia
Ryazan, , Russia
Ryazan, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saint Petersburg, , Russia
Saratov, , Russia
Sestroretsk, , Russia
Smolensk, , Russia
Tomsk, , Russia
Tomsk, , Russia
Yaroslavl, , Russia
Yaroslavl, , Russia
Yaroslavl, , Russia
Yekaterinburg, , Russia
Yekaterinburg, , Russia
Yekaterinburg, , Russia
Belgrade, , Serbia
Belgrade, , Serbia
Belgrade, , Serbia
Kragujevac, , Serbia
Niš, , Serbia
Pančevo, , Serbia
Smederevo, , Serbia
Sremska Mitrovica, , Serbia
Užice, , Serbia
Valjevo, , Serbia
Zaječar, , Serbia
Bratislava, Ružinov, Slovakia
Bardejov, , Slovakia
Bratislava, , Slovakia
Bratislava, , Slovakia
Bratislava, , Slovakia
Bratislava, , Slovakia
Dolný Kubín, , Slovakia
Komárno, , Slovakia
Košice, , Slovakia
Košice, , Slovakia
Košice, , Slovakia
Košice, , Slovakia
Levice, , Slovakia
Levice, , Slovakia
Lučenec, , Slovakia
Lučenec, , Slovakia
Ľubochňa, , Slovakia
Moldava nad Bodvou, , Slovakia
Nitra, , Slovakia
Nové Zámky, , Slovakia
Prešov, , Slovakia
Rožňava, , Slovakia
Svidník, , Slovakia
Šahy, , Slovakia
Štúrovo, , Slovakia
Žilina, , Slovakia
Port Elizabeth, Eastern Cape, South Africa
Port Elizabeth, Eastern Cape, South Africa
Bloemfontein, Free State, South Africa
Bloemfontein, Free State, South Africa
Centurion, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Kempton Park, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Alberton, Guateng, South Africa
Pretoria, Guateng, South Africa
Pretoria, Guateng, South Africa
Durban, KwaZulu-Natal, South Africa
Durban, KwaZulu-Natal, South Africa
Durban, KwaZulu-Natal, South Africa
Merebank, KwaZulu-Natal, South Africa
Thabazimbi, Limpopo, South Africa
Middelburg, Mpumalanga, South Africa
Moloto South, Mpumalanga, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Somerset West, Western Cape, South Africa
Worcester, Western Cape, South Africa
Santiago de Compostela, La Coruña, Spain
A Coruña, , Spain
Almería, , Spain
Barcelona, , Spain
Barcelona, , Spain
Barcelona, , Spain
Barcelona, , Spain
Girona, , Spain
Madrid, , Spain
Madrid, , Spain
Málaga, , Spain
Seville, , Spain
Seville, , Spain
Seville, , Spain
Adana, , Turkey (Türkiye)
Ankara, , Turkey (Türkiye)
Antalya, , Turkey (Türkiye)
Edirne, , Turkey (Türkiye)
Eskişehir, , Turkey (Türkiye)
Istanbul, , Turkey (Türkiye)
Istanbul, , Turkey (Türkiye)
Istanbul, , Turkey (Türkiye)
Izmir, , Turkey (Türkiye)
Kocaeli, , Turkey (Türkiye)
Mersin, , Turkey (Türkiye)
Sivas, , Turkey (Türkiye)
Brovary, , Ukraine
Cherkasy, , Ukraine
Chernivtsi, , Ukraine
Dnipro, , Ukraine
Dnipro, , Ukraine
Dnipro, , Ukraine
Dnipro, , Ukraine
Ivano-Frankivsk, , Ukraine
Ivano-Frankivsk, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kharkiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Kyiv, , Ukraine
Lutsk, , Ukraine
Lviv, , Ukraine
Lviv, , Ukraine
Mykolaiv, , Ukraine
Odesa, , Ukraine
Sumy, , Ukraine
Ternopil, , Ukraine
Uzhhorod, , Ukraine
Vinnytsia, , Ukraine
Vinnytsia, , Ukraine
Vinnytsia, , Ukraine
Vinnytsia, , Ukraine
Vinnytsia, , Ukraine
Zaporizhzhia, , Ukraine
Zaporizhzhia, , Ukraine
Zaporizhzhia, , Ukraine
Zaporizhzhia, , Ukraine
Zaporizhzhia, , Ukraine
Zaporizhzhia, , Ukraine
Zhytomyr, , Ukraine
Reading, Berkshire, United Kingdom
Plymouth, Devon, United Kingdom
Plymouth, Devon, United Kingdom
Stockton-on-Tees, Durham, United Kingdom
Basildon, Essex, United Kingdom
London, Greater London, United Kingdom
Manchester, Greater Manchester, United Kingdom
East Kilbride, Lanarkshire, United Kingdom
Blackpool, Lancashire, United Kingdom
Chorley, Lancashire, United Kingdom
Edinburgh, Lothian Region, United Kingdom
Liverpool, Merseyside, United Kingdom
Airdrie, North Lanarkshire, United Kingdom
Hexham, Northumberland, United Kingdom
Axbridge, Somerset, United Kingdom
Bath, Somerset, United Kingdom
Cardiff, South Glamorgan, United Kingdom
Glasgow, Strathclyde, United Kingdom
Chertsey, Surrey, United Kingdom
Dundee, Tayside Region, United Kingdom
Birmingham, West Midlands, United Kingdom
Wakefield, Yorkshire and the Humber, United Kingdom
Wakefield, Yorkshire, United Kingdom
Blackpool, , United Kingdom
Chesterfield, , United Kingdom
Crownhill, , United Kingdom
Lincoln, , United Kingdom
Oldham, , United Kingdom
Royal Leamington Spa, , United Kingdom
Sandbach, , United Kingdom
Whitby, , United Kingdom
Countries
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References
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Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PHE, Steinberg GR, Lalwani ND. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016 Nov 28;7:13457. doi: 10.1038/ncomms13457.
Bilen O, Ballantyne CM. Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase. Curr Atheroscler Rep. 2016 Oct;18(10):61. doi: 10.1007/s11883-016-0611-4.
Thompson PD, MacDougall DE, Newton RS, Margulies JR, Hanselman JC, Orloff DG, McKenney JM, Ballantyne CM. Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance. J Clin Lipidol. 2016 May-Jun;10(3):556-67. doi: 10.1016/j.jacl.2015.12.025. Epub 2016 Jan 6.
Thompson PD, Rubino J, Janik MJ, MacDougall DE, McBride SJ, Margulies JR, Newton RS. Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance. J Clin Lipidol. 2015 May-Jun;9(3):295-304. doi: 10.1016/j.jacl.2015.03.003. Epub 2015 Mar 19.
Nicholls S, Lincoff AM, Bays HE, Cho L, Grobbee DE, Kastelein JJ, Libby P, Moriarty PM, Plutzky J, Ray KK, Thompson PD, Sasiela W, Mason D, McCluskey J, Davey D, Wolski K, Nissen SE. Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021 May;235:104-112. doi: 10.1016/j.ahj.2020.10.060. Epub 2020 Oct 24.
Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, Thompson PD, Libby P, Cho L, Plutzky J, Bays HE, Moriarty PM, Menon V, Grobbee DE, Louie MJ, Chen CF, Li N, Bloedon L, Robinson P, Horner M, Sasiela WJ, McCluskey J, Davey D, Fajardo-Campos P, Petrovic P, Fedacko J, Zmuda W, Lukyanov Y, Nicholls SJ; CLEAR Outcomes Investigators. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023 Apr 13;388(15):1353-1364. doi: 10.1056/NEJMoa2215024. Epub 2023 Mar 4.
Nissen SE, Menon V, Nicholls SJ, Brennan D, Laffin L, Ridker P, Ray KK, Mason D, Kastelein JJP, Cho L, Libby P, Li N, Foody J, Louie MJ, Lincoff AM. Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients. JAMA. 2023 Jul 11;330(2):131-140. doi: 10.1001/jama.2023.9696.
Nicholls SJ, Ray KK, Lincoff AM, Sarnes E, Gillard KK, Bloedon L, Migliaccio-Walle K, Elsea D, Nissen SE. Cost-Effectiveness of Bempedoic Acid in High Cardiovascular Risk Patients with Statin Intolerance: An Analysis of the CLEAR Outcomes Trial. Am J Cardiovasc Drugs. 2025 Aug 20. doi: 10.1007/s40256-025-00753-w. Online ahead of print.
Laufs U, Lincoff AM, Nicholls SJ, Li N, Bloedon L, Sasiela WJ, Powell HA, Herout PM, Thompson PD, Nissen SE. Characteristics and outcomes of patients with and without statin-associated muscle symptoms treated with bempedoic acid in the CLEAR Outcomes trial. J Clin Lipidol. 2025 Mar-Apr;19(2):337-347. doi: 10.1016/j.jacl.2024.12.014. Epub 2024 Dec 25.
Bays HE, Bloedon L, Brennan D, Lei L, Lincoff AM, Nicholls SJ, Plutzky J, Powell HA, Nissen SE. Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis. J Am Heart Assoc. 2025 Feb 18;14(4):e037898. doi: 10.1161/JAHA.124.037898. Epub 2025 Feb 8.
Lincoff AM, Ray KK, Sasiela WJ, Haddad T, Nicholls SJ, Li N, Cho L, Mason D, Libby P, Goodman SG, Nissen SE. Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs. J Am Coll Cardiol. 2024 Jul 9;84(2):152-162. doi: 10.1016/j.jacc.2024.04.048.
Ray KK, Nicholls SJ, Li N, Louie MJ, Brennan D, Lincoff AM, Nissen SE; CLEAR OUTCOMES Committees and Investigators. Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial. Lancet Diabetes Endocrinol. 2024 Jan;12(1):19-28. doi: 10.1016/S2213-8587(23)00316-9. Epub 2023 Dec 4.
Ridker PM, Lei L, Louie MJ, Haddad T, Nicholls SJ, Lincoff AM, Libby P, Nissen SE; CLEAR Outcomes Investigators. Inflammation and Cholesterol as Predictors of Cardiovascular Events Among 13 970 Contemporary High-Risk Patients With Statin Intolerance. Circulation. 2024 Jan 2;149(1):28-35. doi: 10.1161/CIRCULATIONAHA.123.066213. Epub 2023 Nov 6.
Provided Documents
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Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Other Identifiers
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1002-043
Identifier Type: -
Identifier Source: org_study_id
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