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Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma

NCT ID: NCT02988102

Last Updated: 2016-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2017-08-31

Brief Summary

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In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms.

Most emergency management protocols are focused exclusively on the identification of the relatively small number of patients who may require operative intervention, as early surgery is believed to improve outcome.

Detailed Description

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However early rehabilitation can also be effective for the much larger number of patients who do not require surgery\[1\] In addition, Hall and others recently reported that low doses of ionizing radiation to the brain in infancy may influence cognitive abilities in adulthood. \[2\] Accordingly, increased serum concentrations of, for example S100B ( a calcium-binding protein present in high concentrations in glial cells) and neurone-specific enolase ( NSE: a cytoplasmatic enzyme occuring predominantly in neurones ) have been demonstrated to reflect the presence and severity of brain tissue damage in acute head injuries. \[3\] In both pediatric age and adults.

Conditions

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Biomarkers

Keywords

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S100B, NSE moderate brain trauma mild brain trauma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Following S100B and NSE in head trauma

Following S100B and NSE in head trauma in correlation with Head CT and post concussion syndrome and Lisat11

Intervention Type OTHER

Other Intervention Names

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S100B NSE

Eligibility Criteria

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Inclusion Criteria

* Only head trauma without any other body injury

Exclusion Criteria

* Blood thinner, hydrocephalus , previous brain infarcts, encephalopathy, birth trauma.
Minimum Eligible Age

1 Year

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Clinical Centre of Kosova

OTHER

Sponsor Role lead

Responsible Party

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Dr. Fatos Kelmendi

Dr. Fatos Kelmendi Neurosurgeon

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fatos Kelmendi

Tirana, Kosovo Prishtina, Albania

Site Status RECRUITING

Countries

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Albania

Central Contacts

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Fatos Kelmendi

Role: CONTACT

Phone: +377 44 128 255

Email: [email protected]

Agon Mekaj, PhD

Role: CONTACT

Phone: +377 44 373545

Email: [email protected]

Facility Contacts

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Agon Mekaj, PhD

Role: primary

Ridvan Alimehmeti, PhD

Role: backup

Other Identifiers

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FKelmendi

Identifier Type: -

Identifier Source: org_study_id