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Immunmodulation in Patients With HHT

NCT ID: NCT02983253

Last Updated: 2019-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

124 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-30

Study Completion Date

2019-10-31

Brief Summary

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Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder. Literature suggests that HHT is often associated with higher frequency of infectious diseases.

The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.

Detailed Description

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Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder with recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. Literature and the investigators' observation suggest that HHT is often associated with higher frequency of infectious diseases. This might be a hint for a immunocompromised situation.

The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.

Conditions

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Hereditary Haemorrhagic Telangiectasia (HHT)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients with HHT

blood sample of patients with HHT

blood sample

Intervention Type OTHER

none, only laboratory tests on blood serum

probands

blood sample of healthy controls

blood sample

Intervention Type OTHER

none, only laboratory tests on blood serum

Interventions

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blood sample

none, only laboratory tests on blood serum

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* aged 18 or over, HHT

Exclusion Criteria

* Unable to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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Urban Geisthoff

Prof. Dr. med. Urban Geisthoff

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Urban Geisthoff, Prof.Dr.med.

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Essen

Locations

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University Hospital Essen

Essen, , Germany

Site Status

Countries

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Germany

Other Identifiers

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ImmunUHEssen

Identifier Type: -

Identifier Source: org_study_id