A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT

NCT ID: NCT02981446

Last Updated: 2024-03-15

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

370 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2019-01-31

Brief Summary

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The purpose of this study is to investigate the intraocular pressure-lowering effect and the safety of DE-117 ophthalmic solution compared with Latanoprost ophthalmic solution in subjects with open angle glaucoma or ocular hypertension.

Detailed Description

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Conditions

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Open Angle Glaucoma or Ocular Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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DE-117 ophthalmic solution

Group Type EXPERIMENTAL

DE-117

Intervention Type DRUG

DE-117 ophthalmic solution will be taken one drop, once daily for 3 months in both eyes.

Latanoprost ophthalmic solution 0.005%

Group Type ACTIVE_COMPARATOR

Latanoprost ophthalmic solution

Intervention Type DRUG

Latanoprost ophthalmic solution will be taken one drop, once daily for 3 months in both eyes.

Interventions

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DE-117

DE-117 ophthalmic solution will be taken one drop, once daily for 3 months in both eyes.

Intervention Type DRUG

Latanoprost ophthalmic solution

Latanoprost ophthalmic solution will be taken one drop, once daily for 3 months in both eyes.

Intervention Type DRUG

Other Intervention Names

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Xalatan

Eligibility Criteria

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Inclusion Criteria

* Patients with open angle glaucoma or ocular hypertension in both eyes

Exclusion Criteria

* Patients at risk of progression of visual field loss
* Patients with severe visual field defect
* Patients with any diseases that preclude participation in this study for safety reasons
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Santen Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Singapore, , Singapore

Site Status

Countries

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Singapore

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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01171505

Identifier Type: -

Identifier Source: org_study_id

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