MRI-based Neuroimaging Predictors of Clinical Improvements Following Therapy in Children With Cerebral Palsy
NCT ID: NCT02979743
Last Updated: 2018-06-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2016-12-31
2019-12-31
Brief Summary
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Detailed Description
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This prospective cohort study will include children with occupational therapy (OT) or OT plus acupuncture and massage methods. Children with CP will be evaluated in terms of upper limb motor function using the manual ability classification system (MACS), fine motor function measure (FMFM). The Brain injuries of Children will be evaluated by MRI.
The aim of this study is to explore the relationship between brain MRI-metrics and hand function, compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictors of clinical improvements following therapy in children with CP.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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Occupational therapy group
The children worked with an occupational therapist for 4 hours a day for 5 days per week (totaling 40 hours) and initially concentrated on unilateral activities with the hemiplegic hand,and added bilateral activities during the second week.
Occupational therapy
Occupational therapy puls acupuncture and massage methods
The patients receive occupational therapy puls acupuncture and massage methods.
Occupational therapy
Occupational therapy puls acupuncture and massage methods
Interventions
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Occupational therapy
Occupational therapy puls acupuncture and massage methods
Eligibility Criteria
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Inclusion Criteria
* Spastic cerebral palsy
* The complete clinical and MRI data
Exclusion Criteria
* botulinum toxin upper limb injections
* braces artifact, excessive motion, afraid to enter the MRI
* parents were not interested in the MRI sessions
3 Years
18 Years
ALL
No
Sponsors
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Shenzhen Children's Hospital
OTHER_GOV
General Hospital of Ningxia Medical University
OTHER
Xijing Hospital
OTHER
Second Affiliated Hospital of Wenzhou Medical University
OTHER
Shaanxi Provincial People's Hospital
OTHER
Baoji Central Hospital
OTHER
Children's Hospital of Fudan University
OTHER
Hainan People's Hospital
OTHER
Zunyi Medical College
OTHER
First Affiliated Hospital Xi'an Jiaotong University
OTHER
Responsible Party
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Locations
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First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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Jian Yang, Ph.D.,M.D.
Role: primary
References
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Liu H, Jiang H, Wang X, Zheng J, Zhao H, Cheng Y, Tao X, Wang M, Liu C, Huang T, Wu L, Jin C, Li X, Wang H, Yang J. Treatment response prediction of rehabilitation program in children with cerebral palsy using radiomics strategy: protocol for a multicenter prospective cohort study in west China. Quant Imaging Med Surg. 2019 Aug;9(8):1402-1412. doi: 10.21037/qims.2019.04.04.
Other Identifiers
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2016YFC0100300CP01
Identifier Type: -
Identifier Source: org_study_id