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Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation

NCT ID: NCT02978378

Last Updated: 2024-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

2 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-01

Study Completion Date

2018-03-23

Brief Summary

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The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.

Detailed Description

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Conditions

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Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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biomarker levels

The level of the biomarker hyaluronic acid will be measured

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age more than 18 years
* refractory or advanced cardiogenic shock prior to institution of VA-ECMO

Exclusion Criteria

* History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min
* Cognitive impairment
* Pregnant women
* patient or surrogate is not fluent in English
* Long-term immunosuppression
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Milton S. Hershey Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Anthony Bonavia

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anthony Bonavia

Role: PRINCIPAL_INVESTIGATOR

Milton S. Hershey Medical Center

Locations

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Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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STUDY00006088

Identifier Type: -

Identifier Source: org_study_id