Circulating Tumor Cells and Tumor DNA in HCC and NET

NCT ID: NCT02973204

Last Updated: 2021-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

167 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-30

Study Completion Date

2020-01-08

Brief Summary

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Background Treatment and control of cancer is associated with high costs, to patients in the form of side effects and discomfort during investigations, to society in the form of expensive drugs and studies.

Circulating tumor cells (CTC) has received great attention as a cancer biomarker in trying to estimate future course in patients with breast cancer, colon cancer and prostate cancer. CTC is believed to be a crucial step in cancer spreading to the bloodstream and giving rise to metastases. Detection of circulating tumor DNA (ctDNA) specifically adds specificity to the analysis of the CTC.

The investigators would like to with molecular biological methods predict which patients requires special monitoring and individualized therapy and explore these tests as clinical decision support.

Purpose and method

In a blood sample from patients with neuro-endocrine tumor (NET) and hepatocellular carcinoma (HCC), the investigators will by cell separation, flow cytometry and DNA sequencing and digital polymerase chain reaction (PCR):

1. Identify and isolate the CTC and investigate these for tumor-specific mutations.
2. Quantify ctDNA and analyze this for specific mutations, which in the past has been found frequent in NET and HCC.
3. Compare findings of mutations on CTC and ctDNA with mutations in tissue biopsies.

The results are compared with the clinical data on disease course, including the effect of treatment and survival.

Subjects 40 Patients with small intestinal/unknown primary NET before treatment with somatostatin analogues 30 patients with pancreatic NET before treatment with Everolimus 30 patients with presumed radically treated HCC 30 patients with HCC in treatment with Sorafenib A blood sample will be taken prior to the start of treatment, after 1 month after start of treatment and thereafter every 3.-6. month for up to two years.

Perspectives In several cancer types molecular diagnostics have had significant influence in treatment and control strategy. The goal is in future to be able to take advantage of a so-called "liquid biopsy" as clinical decision support. The study will bring new knowledge to this growing field of research.

Detailed Description

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Conditions

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Carcinoma, Hepatocellular Neuroendocrine Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HCC sorafenib

HCC patients referred for Sorafenib treatment

Sorafenib

Intervention Type DRUG

HCC curative treatment

HCC patient undergoing potential curative treatment, eg. radiofrequency ablation (RFA) or resection

Radiofrequency ablation (RFA) or surgery

Intervention Type PROCEDURE

Intended curative surgery or RFA

NET everolimus

Pancreatic NET patients referred for Everolimus treatment

Everolimus

Intervention Type DRUG

NET ssta

Small intestinal or unknown primary NET patients referred for treatment with somatostatin analogues, eg. lanreotide and octreotide

Lanreotide

Intervention Type DRUG

Or other somatostatin analogues (SSTA), eg. Sandostatin

Interventions

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Sorafenib

Intervention Type DRUG

Radiofrequency ablation (RFA) or surgery

Intended curative surgery or RFA

Intervention Type PROCEDURE

Everolimus

Intervention Type DRUG

Lanreotide

Or other somatostatin analogues (SSTA), eg. Sandostatin

Intervention Type DRUG

Other Intervention Names

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Nexavar Anatomical Therapeutic Chemical Classification System L01XE05 Certican Afinitor Votubia Anatomical Therapeutic Chemical Classification System L01XE10 Ipstyl Sandostatin LAR Octreotide

Eligibility Criteria

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Inclusion Criteria

* one of the above mentioned diseases
* planed surgery, RFA, Somatostatin Analogue, Sorafenib or Everolimus treatment
* signed informed consent

Exclusion Criteria

* age below 18, concomitant invasive cancer (not skin cancer) and planed emigration of Denmark.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jens Kelsen, Consultant

Role: STUDY_CHAIR

Department of Hepatology and Gastroenterology, Aarhus University Hospital

Locations

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Department of Hepatology and Gastroenterology

Aarhus, Aarhus C, Denmark

Site Status

Countries

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Denmark

References

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Other Identifiers

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SK-HCC-NET

Identifier Type: -

Identifier Source: org_study_id

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