Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy

NCT ID: NCT02967926

Last Updated: 2016-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2016-11-30

Brief Summary

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This study aim to evaluated the effectiveness of Digital SpyGlass Cholangioscopy to facilitate common bile duct stone removal without fluoroscopy

Detailed Description

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Patients This study recruited patients who suspected/confirmed CBDS from clinical manifestation, liver function tests and imaging studies. With CBD sized between 5 and 15 millimeters, which measured from transabdominal ultrasonography (US), computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP) or endoscopic ultrasonography (EUS). The exclusion criteria were history of bile duct surgery, bile duct stricture, bile duct tumors, severe comorbid diseases, unstable vital signs, pregnancy, and coagulopathy. All patients were informed and wrote informed consent for the procedure.

Procedures Non-fluoroscopic CBDS removal was performed by experienced endoscopists, using standard side-viewing duodenoscope. After identified major papilla, the investigators performed bile duct cannulation with guidewire assisted technique. Successful cannulation confirmed by visualized bile aspiration. If the patients had difficult cannulation, double guidewire technique was used. After the successful bile duct cannulation, the investigators performed endoscopic standard sphincterotomy (EST). Precut sphincterotomy was not used in this study. Non fluoroscopic balloon extraction was performed. The balloon was pushed up to hilum then the investigators sweep until suspected complete CBD clearance. After that the investigators used digital SpyGlassTM to confirm the complete clearance of CBDS. If SpyGlassTM showed residual CBD stone, the investigators repeat balloon extraction. If SpyGlassTM showed complete clearance, the investigator proceed to perform final cholangiogram as reference standard for this study.

Conditions

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Common Bile Duct Diseases Stone - Biliary Cholangitis, Sclerosing

Keywords

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common bile duct stone cholangioscopy SpyGlass non-fluoroscopic

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ERCP without Fluoroscopy

Non-fluoroscopic common bile duct stone extraction

Group Type EXPERIMENTAL

Endoscopic Retrograde Cholangioscopy by SpyGlass (ERCS)

Intervention Type PROCEDURE

Digital SpyGlass Cholangioscopy to facilitate common bile duct stone removal

Interventions

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Endoscopic Retrograde Cholangioscopy by SpyGlass (ERCS)

Digital SpyGlass Cholangioscopy to facilitate common bile duct stone removal

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with clinically suspected/confirmed CBDS
* CBD caliber 5-15 mm

Exclusion Criteria

* History of bile duct surgery
* History of bile duct tumor
* History of bile duct stricture
* Severe comorbidity
* Unstable vital signs
* Pregnancy
* Coagulopathy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role collaborator

Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Thanawat Luangsukrerk

Gastrointestinal Endoscopy Excellence Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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791/2016

Identifier Type: -

Identifier Source: org_study_id