Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2017-01-31
2017-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Mild hypoxia preconditioning
Patients will be treated with mild hypoxia (Note: The oxygen concentration decreased from 20% to 18%, and keeping at 18%) before surgery.
Mild Hypoxia Preconditioning
Patients will be treated with mild hypoxia ( Note: The oxygen concentration decreased from 20% to 18%, and keeping at 18%)×7 days，twice a day in the morning and in the afternoon before surgery.
Sham preconditioning
Patients will be treated with sham preconditioning (oxygen concentration: 21％) before surgery.
Sham preconditioning
Patients will be treated with sham preconditioning (oxygen concentration: 21％) ×7 days，twice a day in the morning and in the afternoon before surgery.
Interventions
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Mild Hypoxia Preconditioning
Patients will be treated with mild hypoxia ( Note: The oxygen concentration decreased from 20% to 18%, and keeping at 18%)×7 days，twice a day in the morning and in the afternoon before surgery.
Sham preconditioning
Patients will be treated with sham preconditioning (oxygen concentration: 21％) ×7 days，twice a day in the morning and in the afternoon before surgery.
Eligibility Criteria
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Inclusion Criteria
2. Han nationality, age \>18 years.
3. Carotid artery stenosis on at least one side, measuring more than 70% by ultrasonic detection and requiring carotid artery stenting or a carotid endarterectomy.
4. Long-term residence at an altitude of \<100 m (the altitude of Tianjin is 2-5 m).
5. Not having been to an altitude ≥1500 m in two years.
Exclusion Criteria
2. Systemic blood disease before intervention.
3. Regular physical activity exercise: frequency \>1 time/week, duration \>20 min.
4. History of brain disease or history of stroke or transient ischemic attack within the previous six months.
5. History of heart, liver, kidney or lung disease.
6. History of hypertension and poor blood pressure control, with blood pressure \>160/90 mmHg.
7. Pregnancy.
18 Years
ALL
No
Sponsors
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Hua Yan
OTHER
Responsible Party
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Hua Yan
Director
Principal Investigators
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Hua Yan, Doctor
Role: STUDY_CHAIR
Tianjin Huanhu Hospital
Locations
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Tianjin HuanHu Hospital
Tianjin, Tianjin Municipality, China
Countries
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Other Identifiers
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JH2016-17
Identifier Type: -
Identifier Source: org_study_id
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