PATET Ratio to Rule Out Transient Tachypnea of the Newborn
NCT ID: NCT02965365
Last Updated: 2016-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
105 participants
OBSERVATIONAL
2016-01-31
2016-10-31
Brief Summary
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Detailed Description
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In several studies pulmonary artery Doppler indices are investigated as the possible indicators of pulmonary function. As a result of these studies, physiological processes in fetal lung maturation were established; pulmonary tissue impedance or resistance decreases with increasing gestational age, leading to increased pulmonary blood flow. In a normal lung maturation process the peak sistolic velocity is reached in midsystole, but in case of any reason disturbing the nornal development process,the peak occurs earlier.
We suggested that TTN, which is a factor increasing pulmonary tissue impedance like respiratory distress syndrome(RDS) and pulmonary hypoplasia, would change pulmonary artery(PA) Doppler indices, thus by the way of evaluating pulmonary artery Doplerr indices, we could predict possible diagnosis of TTN
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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TTN positive group
The group which subsequently diagnosed as TTN
No interventions assigned to this group
TTN negative group
The group which is not diagnosed as TTN
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
35 Years
FEMALE
Yes
Sponsors
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Kayseri Education and Research Hospital
OTHER_GOV
Responsible Party
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Hatice Akkaya
Principle investigator
Principal Investigators
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Barış Büke, resident
Role: PRINCIPAL_INVESTIGATOR
Kayseri Education and Research Hospital
Locations
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Kayseri Doğumevi
Kocasinan, Kayseri, Turkey (Türkiye)
Countries
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References
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Guglani L, Lakshminrusimha S, Ryan RM. Transient tachypnea of the newborn. Pediatr Rev. 2008 Nov;29(11):e59-65. doi: 10.1542/pir.29-11-e59. No abstract available.
Demirel G, Uras N, Celik IH, Canpolat FE, Dilmen U. Nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for transient tachypnea of newborn: a randomized, prospective study. J Matern Fetal Neonatal Med. 2013 Jul;26(11):1099-102. doi: 10.3109/14767058.2013.766707. Epub 2013 Feb 27.
Avery ME, Gatewood OB, Brumley G. Transient tachypnea of newborn. Possible delayed resorption of fluid at birth. Am J Dis Child. 1966 Apr;111(4):380-5. doi: 10.1001/archpedi.1966.02090070078010. No abstract available.
Tudehope DI, Smyth MH. Is "transient tachypnoea of the newborn" always a benign disease? Report of 6 babies requiring mechanical ventilation. Aust Paediatr J. 1979 Sep;15(3):160-5. doi: 10.1111/j.1440-1754.1979.tb01215.x. No abstract available.
Kugelman A, Riskin A, Weinger-Abend M, Bader D. Familial neonatal pneumothorax associated with transient tachypnea of the newborn. Pediatr Pulmonol. 2003 Jul;36(1):69-72. doi: 10.1002/ppul.10283.
Rasanen J, Huhta JC, Weiner S, Wood DC, Ludomirski A. Fetal branch pulmonary arterial vascular impedance during the second half of pregnancy. Am J Obstet Gynecol. 1996 May;174(5):1441-9. doi: 10.1016/s0002-9378(96)70586-0.
Chaoui R, Taddei F, Rizzo G, Bast C, Lenz F, Bollmann R. Doppler echocardiography of the main stems of the pulmonary arteries in the normal human fetus. Ultrasound Obstet Gynecol. 1998 Mar;11(3):173-9. doi: 10.1046/j.1469-0705.1998.11030173.x.
Kitabatake A, Inoue M, Asao M, Masuyama T, Tanouchi J, Morita T, Mishima M, Uematsu M, Shimazu T, Hori M, Abe H. Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation. 1983 Aug;68(2):302-9. doi: 10.1161/01.cir.68.2.302.
Chaoui R, Kalache K, Tennstedt C, Lenz F, Vogel M. Pulmonary arterial Doppler velocimetry in fetuses with lung hypoplasia. Eur J Obstet Gynecol Reprod Biol. 1999 Jun;84(2):179-85. doi: 10.1016/s0301-2115(98)00327-3.
Kim SM, Park JS, Norwitz ER, Hwang EJ, Kang HS, Park CW, Jun JK. Acceleration time-to-ejection time ratio in fetal pulmonary artery predicts the development of neonatal respiratory distress syndrome: a prospective cohort study. Am J Perinatol. 2013 Nov;30(10):805-12. doi: 10.1055/s-0032-1333132. Epub 2013 Jan 4.
Guan Y, Li S, Luo G, Wang C, Norwitz ER, Fu Q, Tu X, Tian X, Zhu J. The role of doppler waveforms in the fetal main pulmonary artery in the prediction of neonatal respiratory distress syndrome. J Clin Ultrasound. 2015 Jul-Aug;43(6):375-83. doi: 10.1002/jcu.22219. Epub 2014 Aug 11.
Rizzo G, Capponi A, Angelini E, Mazzoleni A, Romanini C. Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia. Ultrasound Obstet Gynecol. 2000 Feb;15(2):98-103. doi: 10.1046/j.1469-0705.2000.00006.x.
Rawlings JS, Smith FR. Transient tachypnea of the newborn. An analysis of neonatal and obstetric risk factors. Am J Dis Child. 1984 Sep;138(9):869-71. doi: 10.1001/archpedi.1984.02140470067022.
Clark SL, Meyers JA, Perlin JB. Oversight of elective early term deliveries: avoiding unintended consequences. Am J Obstet Gynecol. 2012 May;206(5):387-9. doi: 10.1016/j.ajog.2011.08.017. Epub 2011 Aug 22.
Martin JA, Hamilton BE, Osterman MJ, Curtin SC, Matthews TJ. Births: final data for 2013. Natl Vital Stat Rep. 2015 Jan 15;64(1):1-65.
Statland BE, Sher G, Freer DE, Kraybill EN, Smith HY, Hisley JC. Evaluation of a modified foam stability (FS-50) test. An assay performed on amniotic fluid to predict fetal pulmonary maturity. Am J Clin Pathol. 1978 May;69(5):514-9. doi: 10.1093/ajcp/69.5.514. No abstract available.
Hagen E, Link JC, Arias F. A comparison of the accuracy of the TDx-FLM assay, lecithin-sphingomyelin ratio, and phosphatidylglycerol in the prediction of neonatal respiratory distress syndrome. Obstet Gynecol. 1993 Dec;82(6):1004-8.
Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, Sumigama S, Hayakawa H, Kotani T, Kikkawa F. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN). J Perinat Med. 2011 May;39(3):245-50. doi: 10.1515/jpm.2011.006. Epub 2011 Feb 11.
Machado MV, Chita SC, Allan LD. Acceleration time in the aorta and pulmonary artery measured by Doppler echocardiography in the midtrimester normal human fetus. Br Heart J. 1987 Jul;58(1):15-8. doi: 10.1136/hrt.58.1.15.
Laudy JA, Gaillard JL, vd Anker JN, Tibboel D, Wladimiroff JW. Doppler ultrasound imaging: a new technique to detect lung hypoplasia before birth? Ultrasound Obstet Gynecol. 1996 Mar;7(3):189-92. doi: 10.1046/j.1469-0705.1996.07030189.x.
Azpurua H, Norwitz ER, Campbell KH, Funai EF, Pettker CM, Kleine M, Bahtiyar MO, Malkus H, Copel JA, Thung SF. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. Am J Obstet Gynecol. 2010 Jul;203(1):40.e1-8. doi: 10.1016/j.ajog.2010.01.075. Epub 2010 Apr 24.
Schenone MH, Samson JE, Jenkins L, Suhag A, Mari G. Predicting fetal lung maturity using the fetal pulmonary artery Doppler wave acceleration/ejection time ratio. Fetal Diagn Ther. 2014;36(3):208-14. doi: 10.1159/000358299. Epub 2014 Aug 13.
Other Identifiers
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E52332816_54
Identifier Type: -
Identifier Source: org_study_id