NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes

NCT ID: NCT02959125

Last Updated: 2017-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-12-12

Study Completion Date

2017-12-20

Brief Summary

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This study evaluates the intervention of Nut Fish based food, micro nutrients supplementation and pregnancy class to improve maternal and birth outcome. This is cluster randomized trial with two arms. The intervention group will receive Nut Fish based supplementation, multiple micro nutrients, and pregnancy class. The control group will receive government food supplementation, iron folic acid supplementation, and pregnancy class.

Detailed Description

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Objectives: To investigate whether a nut fish based food and dietary supplementation delivered to pregnant mothers with health education would benefit maternal and birth outcomes compared with the government standard of care.

Design. A randomized control trial will be implemented in rural community in Indonesia.

Intervention. The 2 trial arms will be control group (government standard of care) and intervention group with nut fish based food and dietary supplementation and health education series in the pregnancy class. A control group will receive government food supplementation package, Iron Folic acid pills and pregnancy class. An intervention group will receive NutFish based food supplementation, multiple micro nutrients, and pregnancy class. As a pilot study, all the intervention packages will be delivered by research team members.

Subjects. A total 72 first trimester of pregnant mothers will be enrolled with 36 pregnant mothers each group.

Outcome measures. Maternal outcome at 1 and 2 month after intervention namely weight increment, energy and protein intake, mid upper arm circumference, and complications. Birth outcomes include APGAR score, birth weight and length, preterm birth.

Analysis. Linear, logistic and multinomial logistic regression.

Conditions

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Pregnancy Protein-Energy Malnutrition Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Intervention

Intervention

* NutFish based supplementation for 60 days
* Multiple micro nutrient for 60 days
* Health education in pregnancy class

Group Type EXPERIMENTAL

NutFish Based Food Supplementation

Intervention Type OTHER

Cookies contain 500 Calories and 15 gram protein make from nut and ocean fish

Multiple micronutrients

Intervention Type DIETARY_SUPPLEMENT

Vitamin A 5000 iu, vitamin D 400 iu, vitamin C 100 mg, vitamin B1 7.5 mg, vitamin B2 3 mg, vitamin B6 10 mg, vitamin B12 10 mcg, fluoride 1 mg, Fe fumarate 91 mg, niacinamide 20 mg, Ca pantothenate 7.5 mg, folic acid 400 mcg, Zn 5 mg, Ca lactate 250 mg, copper 0.1 mg, iodine 0.1 mg

Health Education in Pregnancy Class

Intervention Type BEHAVIORAL

Health education on pregnancy, complication, and breastfeeding by research team members

Control

Control

* Government food supplementation for 60 days
* Iron Folic acid for 60 days
* Health education in pregnancy class

Group Type ACTIVE_COMPARATOR

Health Education in Pregnancy Class

Intervention Type BEHAVIORAL

Health education on pregnancy, complication, and breastfeeding by research team members

Government Food Supplementation

Intervention Type OTHER

Cookies contain 500 Calories and 5 gram protein make from flour and egg

Fe Supplementation

Intervention Type DIETARY_SUPPLEMENT

Ferrous Fumarate 60mg and folic acid 0.400 mg

Interventions

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NutFish Based Food Supplementation

Cookies contain 500 Calories and 15 gram protein make from nut and ocean fish

Intervention Type OTHER

Multiple micronutrients

Vitamin A 5000 iu, vitamin D 400 iu, vitamin C 100 mg, vitamin B1 7.5 mg, vitamin B2 3 mg, vitamin B6 10 mg, vitamin B12 10 mcg, fluoride 1 mg, Fe fumarate 91 mg, niacinamide 20 mg, Ca pantothenate 7.5 mg, folic acid 400 mcg, Zn 5 mg, Ca lactate 250 mg, copper 0.1 mg, iodine 0.1 mg

Intervention Type DIETARY_SUPPLEMENT

Health Education in Pregnancy Class

Health education on pregnancy, complication, and breastfeeding by research team members

Intervention Type BEHAVIORAL

Government Food Supplementation

Cookies contain 500 Calories and 5 gram protein make from flour and egg

Intervention Type OTHER

Fe Supplementation

Ferrous Fumarate 60mg and folic acid 0.400 mg

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Intervention

Eligibility Criteria

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Inclusion Criteria

* First trimester of pregnancy
* Anemic or Mid Upper Arm Circumference \< 23.5cm or no weight gain
* Plan to deliver at village midwives
* residence in the study area

Exclusion Criteria

* severe anemia \< 7.0g/dl
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Semarang Health Polytechnic

OTHER

Sponsor Role lead

Responsible Party

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Kun Aristiati Susiloretni

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kun A Susiloretni, Dr

Role: PRINCIPAL_INVESTIGATOR

Semarang Health Polytechnic

Locations

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Demak District Health Office

Demak, Central Java, Indonesia

Site Status

Public Health Center of Karangawen 2

Demak, Central Java, Indonesia

Site Status

Countries

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Indonesia

References

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Ota E, Hori H, Mori R, Tobe-Gai R, Farrar D. Antenatal dietary education and supplementation to increase energy and protein intake. Cochrane Database Syst Rev. 2015 Jun 2;(6):CD000032. doi: 10.1002/14651858.CD000032.pub3.

Reference Type RESULT
PMID: 26031211 (View on PubMed)

Imdad A, Bhutta ZA. Maternal nutrition and birth outcomes: effect of balanced protein-energy supplementation. Paediatr Perinat Epidemiol. 2012 Jul;26 Suppl 1:178-90. doi: 10.1111/j.1365-3016.2012.01308.x.

Reference Type RESULT
PMID: 22742610 (View on PubMed)

Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2015 Nov 1;2015(11):CD004905. doi: 10.1002/14651858.CD004905.pub4.

Reference Type RESULT
PMID: 26522344 (View on PubMed)

Other Identifiers

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SemarangHP

Identifier Type: -

Identifier Source: org_study_id