Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
13 participants
OBSERVATIONAL
2015-08-31
2016-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CROSSOVER
CROSS_SECTIONAL
Study Groups
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Young
Six young (18-30 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
13C eicosapentaenoic acid and 13C arachidonic acid
Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
Elderly
Six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
13C eicosapentaenoic acid and 13C arachidonic acid
Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
Interventions
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13C eicosapentaenoic acid and 13C arachidonic acid
Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
Eligibility Criteria
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Inclusion Criteria
* healthy non medicated participants.
Exclusion Criteria
* malnutrition (assessed from blood albumin, haemoglobin and lipids), -
* participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
* severe gastro-intestinal problems,
* medication for diabetes,
* thyroid disease,
* renal failure,
* cancer,
* psychiatric difficulties or depression,
* cardiovascular disease,
* glucose intolerance (\>8 mmol/L in fasted samples)
* chronic immune condition or inflammation (CRP \> 10 mg/l, white cell count),
* recent major surgery or cardiac event,
* dementia,
* ongoing or past severe drug or alcohol abuse,
* ongoing or past intensive physical training.
18 Years
MALE
Yes
Sponsors
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Healthy Aging Research Network
NETWORK
Université de Sherbrooke
OTHER
Responsible Party
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Mélanie Plourde
Professor
References
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Leveille P, Chouinard-Watkins R, Windust A, Lawrence P, Cunnane SC, Brenna JT, Plourde M. Metabolism of uniformly labeled 13C-eicosapentaenoic acid and 13C-arachidonic acid in young and old men. Am J Clin Nutr. 2017 Aug;106(2):467-474. doi: 10.3945/ajcn.117.154708. Epub 2017 Jun 28.
Other Identifiers
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13C EPA and 13C AA metabolism
Identifier Type: -
Identifier Source: org_study_id