The ePass Clinical Trial for the Treatment of Obese Subjects

NCT ID: NCT02954016

Last Updated: 2016-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2022-03-31

Brief Summary

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To evaluate the safety and efficacy of the endoscopically implanted ValenTx EndoPass™ System for treatment of adults with severe obesity.

The EndoPass System is indicated for weight loss in adults with a body mass index (BMI) ≥35 and ≤ 50 kg/m2 who have failed more conservative weight loss methods.

Detailed Description

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* Single-arm, multi-center study conducted in up to 50 subjects at up to 5 sites.
* Subjects will be implanted with the EndoPass device for up to 36 months.
* Body weight, adverse events and device function will be monitored at monthly visits for the first year after implant and quarterly visits thereafter.
* Additional follow-up data will include vital signs, hip and waist circumference, blood lab tests, endoscopic and esophagram assessments of the condition of the implanted device, quality of life and eating behavior questionnaires.
* All subjects will be followed for 12 months after device removal.
* A single device renewal may take place as needed after the initial implant.
* Subject study participation may last up to four years, but is expected to vary with implant duration, which will be determined on a case-by-case basis.

Conditions

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Obesity

Keywords

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Obesity Weight Loss Hypertension Type 2 Diabetes Mellitus Hyperlipidemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ePass

Subjects implanted with the investigational ValenTx Endo Bypass System

Group Type EXPERIMENTAL

ePass

Intervention Type DEVICE

Subject is implanted with the device for up to 3 years.

Interventions

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ePass

Subject is implanted with the device for up to 3 years.

Intervention Type DEVICE

Other Intervention Names

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ValenTx Endo Bypass System EBS

Eligibility Criteria

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Inclusion Criteria

* 18-60 years of age.
* BMI ≥ 35 and ≤ 50 kg/m2
* Documented failure with non-surgical weight loss methods
* Self-reported maximum and minimum body weights during the past 12 months within 10% of current body weight

Exclusion Criteria

* Pregnancy or intention of becoming pregnant.
* Past history of esophageal, gastric or bariatric surgery.
* Medical conditions contraindicating elective endoscopic or bariatric procedures.
* Insulin-dependent diabetes mellitus
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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ValenTx, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Roland Maude-Griffin

Role: STUDY_DIRECTOR

ValenTx, Inc.

Locations

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Hospital Italiano de Mendoza / Clinica Quiriurgica

Mendoza, , Argentina

Site Status

Swiss Hospital / Especialidades Bariatrices

Monterrey, Nuevo León, Mexico

Site Status

Countries

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Argentina Mexico

Other Identifiers

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EP 1.0

Identifier Type: -

Identifier Source: org_study_id