Transfusion Strategies for Pediatric Liver Transplantation
NCT ID: NCT02951013
Last Updated: 2021-10-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
488 participants
INTERVENTIONAL
2016-12-07
2022-12-30
Brief Summary
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The primary outcome: Survival rate in six months after randomization.
Secondary outcomes: Incidence of perioperative complications, including sepsis , pulmonary complications, portal vein thrombosis, hepatic artery thrombosis and transfusion-related adverse events. Intraoperative blood loss, intraoperative blood transfusion amount, postoperative blood transfusion amount in 7 days after surgery, postoperative inflammatory reaction, mechanical ventilation time in the intensive care unit, lengths of stay in the intensive care unit and the hospital，and hospitalization expenses.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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restrictive group
Patients in this group will have a transfusion when the hemoglobin concentration falls below 6g/dL, with a target hemoglobin range of 7.5-8.0g/dL.
restrictive transfusion
Transfusion will start when the hemoglobin concentration falls below 6.0 g/dL
liberal group
Patients in this group will have a transfusion when the hemoglobin concentration falls below 8g/dL, with a target hemoglobin range of 9.5-10.0g/dL.
liberal transfusion
Interventions
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restrictive transfusion
Transfusion will start when the hemoglobin concentration falls below 6.0 g/dL
liberal transfusion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
36 Months
ALL
No
Sponsors
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RenJi Hospital
OTHER
Responsible Party
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Principal Investigators
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Jie Tian
Role: PRINCIPAL_INVESTIGATOR
RenJi Hospital
Locations
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Renji Hospital affliated to Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PLT20161023
Identifier Type: -
Identifier Source: org_study_id