Efficacy and Safety of Prurisol Administered Orally for Active Moderate to Severe Chronic Plaque Psoriasis

NCT ID: NCT02949388

Last Updated: 2018-02-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 199 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-11-30
• Study Completion Date: 2017-12-31

Brief Summary

This study is designed as a randomized, double blind, parallel group, placebo-controlled trial to study the efficacy and safety of two oral doses of Prurisol administered twice daily for twelve weeks to subjects with moderate to severe chronic plaque psoriasis.

Detailed Description

This study is designed as a randomized, double blind, parallel group, placebo-controlled trial to study the efficacy and safety of two oral doses of Prurisol administered twice daily for twelve weeks to subjects with moderate to severe chronic plaque psoriasis.

Approximately 189 study participants will be enrolled. Subjects will be randomly assigned to one of three treatment groups in a 3:3:1 randomization ratio, respectively.

• Group A (n=81): Prurisol 150 mg bid
• Group B (n=81): Placebo
• Group C (n=27): Prurisol 200 mg bid Outpatient subjects with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy will be recruited to the study. Study participants are required to have a Psoriasis Area and Severity Index (PASI) score ≥ 12, body surface area involvement ≥ 10%, and a static Physician's Global Assessment (sPGA) of moderate or severe (score of 3 or 4).

A subject studied under this clinical protocol will commence with a screening period of up to 4 weeks, a treatment period of 12 weeks, and a follow-up period of 4 weeks ending with an End of Study evaluation.

During treatment, subjects will return to the study center every 2 weeks. Efficacy assessments, including physician and patient rated endpoints, will be measured throughout the study. Safety and tolerability will be assessed by ascertainment of AEs and results of clinical laboratory testing, vital signs assessments, and need for concomitant medications.

At a subset of sites, blood samples for determination of plasma concentrations of Prurisol (abacavir glycolate) and abacavir, it's metabolite, will be obtained from subjects who consent to provide these samples. At selected sites, for those subjects consenting to photography, standardized digital photographs will be obtained for illustrative purposes.

Conditions

Chronic Stable Plaque Psoriasis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Placebo

Placebo Comparator: Placebo daily Two (2) placebo capsules given twice daily (AM and PM) for 84 (± 2 days

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Two capsules (both containing Placebo enclosed) taken twice a day and approximately 12 hours apart

300 mg (150 mg BID)

Active Comparator: 300 mg of Prurisol daily One (1) capsule containing 100 mg Prurisol and one (1) capsule containing 50 mg of Prurisol given twice (AM and PM) for 84 (± 2) days

Group Type: ACTIVE_COMPARATOR

300 mg (150 mg BID)

Intervention Type: DRUG

Two capsules (one containing 50mg tablet and one containing two 50 mg tablets) taken twice a day and approximately 12 hours apart

400 mg (200 mg BID)

Active Comparator: 400 mg of Prurisol daily Two (2) capsule each containing 100 mg Prurisol given twice daily (AM and PM) for 84 (± 2) days

Group Type: ACTIVE_COMPARATOR

400 mg (200 mg BID)

Intervention Type: DRUG

Two capsules (both containing two 50mg tablets enclosed) taken twice a day and approximately 12 hours apart

Interventions

Placebo

Two capsules (both containing Placebo enclosed) taken twice a day and approximately 12 hours apart

Intervention Type: DRUG

400 mg (200 mg BID)

Two capsules (both containing two 50mg tablets enclosed) taken twice a day and approximately 12 hours apart

Intervention Type: DRUG

300 mg (150 mg BID)

Two capsules (one containing 50mg tablet and one containing two 50 mg tablets) taken twice a day and approximately 12 hours apart

Intervention Type: DRUG

Other Intervention Names

Prurisol; Prurisol

Eligibility Criteria

Inclusion Criteria

1. Evidence of a personally signed and dated written informed consent to participate in the clinical study

2. Male or non-pregnant female adults at least 18 years of age at time of informed consent

3. Chronic plaque-type psoriasis diagnosed for at least 6 months prior to baseline (at time of first study dose)

4. Moderate to severe plaque psoriasis as defined at baseline by:

1. PASI score of 12 or greater, and

2. Static PGA score of moderate (3) or severe (4), and

3. Body Surface Area (BSA) affected by plaque-type psoriasis of 10% or greater

5. Candidate for systemic therapy or phototherapy

6. Willing to limit ultraviolet light exposure from sunbathing, use of tanning booths, prolonged outdoor exposure, or from other UV light sources during the study.

7. Willing and able to comply with scheduled visits, study assessments and l laboratory tests, and other study procedures

Exclusion Criteria

1. Positive blood test for HLA-B*5701 allele

2. Currently have forms of psoriasis other than chronic plaque-type, (e.g., guttate, erythrodermic, exfoliative, palmoplantar, pustular), with the exception of nail psoriasis

3. Evidence of drug-induced psoriasis, e.g., a new onset or current exacerbation of psoriasis from beta-blockers, calcium channel inhibitors, antimalarial drugs or lithium

4. Psoriasis flare or rebound within 4 weeks prior to Screening

5. Active inflammatory diseases other than psoriasis that might confound the evaluation of study treatment on signs and symptoms of psoriasis.

6. . Any of the following prohibited treatments that do not meet the specified minimum washout period:

1. Biologic immunomodulating treatments of brodalumab or ustekinumab within 24 weeks prior to start of study treatment

2. Biologic immunomodulating treatments such as adalimumab, etanercept, infliximab, ixekizumab, secukinumab or certolizumab pegol within 12 weeks prior to start of study treatment

3. Systemic immunomodulating treatments other than biologics within 4 weeks prior to start of study treatment, e.g., oral corticosteroids, injectable corticosteroids (intraarticular, intramuscular, cutaneous/subcutaneous or intravenous), methotrexate, cyclosporine, cyclophosphamide, apremilast

• Inhaled or intranasal corticosteroids with predominantly local effect (e.g., to treat asthma) are allowable
• Use of corticosteroids in the eye or the ear are allowable

4. Other systemic treatments for psoriasis within 4 weeks prior to start of study treatment, e.g., retinoids, fumarates

• Any such treatment used to treat a symptom of psoriasis but not the condition itself (e.g., anti-histamines for pruritus) is not restricted

5. Photochemotherapy, e.g., Psoralens + UVA phototherapy (PUVA), within 4 weeks prior to start of study treatment

6. Phototherapy, e.g., UVA, UVB, within 2 weeks prior to start of study treatment

7. Topical treatments that could affect signs and symptoms of psoriasis within 2 weeks prior to start of study treatment, e.g., corticosteroids, vitamin D analogs, retinoids, pimecrolimus, tacrolimus, tars, keratolytics

• Allowable exceptions are: low or least potent (Class 6 or 7) topical corticosteroids for use on face, palms, soles, and intertriginous areas only; tar and salicylic acid preparations/shampoos for use on scalp only; bland emollient for use on any body region

7. Past vaccination with live vaccine within 6 weeks prior to start of study treatment, or plans for administration during the study

8. Any investigational or experimental therapy or procedure or participation in any interventional trial within 4 weeks or 5 half-lives (whichever is longer) prior to start of study treatment

9. Women of child-bearing potential who are not using reliable means of contraception, e.g., abstinence, surgical sterilization (hysterectomy and/or bilateral oophorectomy or partner vasectomy) or tubal ligation, double barrier method, oral/ injected/ implanted/ transdermal hormonal contraception, intrauterine device or intrauterine system, throughout study participation, and for 4 weeks after the end of treatment

10. Women of child-bearing potential who are pregnant or nursing (lactating), or planning a pregnancy while participating in the study

11. History of any ongoing, chronic or recurrent infectious disease (with the exception of episodic herpes labialis and herpes genitalis, and vaginal yeast infections)

12. Evidence of tuberculosis infection as defined by a positive QuantiFERON®-TB Gold In-Tube test (QFT-G) at Screening, or subjects with an indeterminate QFT-G test result with any retest result as indeterminate or positive

13. History of either untreated or incompletely treated latent or active tuberculosis infection

14. Ongoing or recent history of any non-psoriatic uncontrolled (in the Investigator's medical opinion) systemic disease, including, but not limited to renal, hepatic, hematologic, gastrointestinal, endocrine, metabolic, pulmonary, cardiac, neurologic, or psychiatric disease. (e.g., A past or current history of hypertension that is controlled with diet and/or medications is not exclusionary.)

15. History of lymphoproliferative disease or any known malignancy or history of malignancy of any organ system within the past 5 years with the exception of: basal cell or squamous cell carcinoma or actinic keratoses that have been treated or excised with no evidence of recurrence in the past 12 weeks; cervical carcinoma in situ or non-invasive malignant colon polyps that have been removed

16. Active systemic infections during the past two weeks (exception: common cold) prior to start of study treatment or any infection that reoccurs on a regular basis

17. Past medical history of infection with HIV, hepatitis B or hepatitis C

18. History of any allergic reaction to any formulation of abacavir

19. Previous treatment with any abacavir-containing product, e.g., Ziagen®, Epzicom®, or Trizivir®

20. Previous participation in a clinical study of Prurisol

21. Presence of any medical or psychiatric condition that, in the Investgator's opinion, makes it unlikely that the requirements of the protocol will be completed

22. History of alcohol or substance abuse, unless in full remission for more than 6 months prior to start of study treatment

23. Electrocardiogram (ECG) obtained at Screening visit which shows medically relevant abnormalities which may affect subject safety or interpretation of study results

24. Observed clinical laboratory values/abnormalities during Screening that show any one or more of the following:

1. Screening total white blood cell (WBC) count <2.5 x 10^9/L, or platelets <100 x 10^9/L or neutrophils <1.2 x 10^9/L or hemoglobin <8.5 g/dL

2. Screening serum creatinine level exceeding 2.0 mg/dL (176.8 µmol/L)

3. Screening alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels > 2 x ULN

25. Any other severe acute or chronic medical or psychiatric condition or test abnormality(ies) that, in the Investigator's opinion, puts the subject at significant risk, could confound the study results, or may interfere significantly with the subject's participation in the study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Innovation Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Study Site

Glendale, Arizona, United States

Study Center

Hot Springs, Arkansas, United States

Clinical Study Site

Rogers, Arkansas, United States

Study Center

Los Angeles, California, United States

Study Site

Los Angeles, California, United States

Clinical Study Site

Murrieta, California, United States

Clinical Study Site

Oceanside, California, United States

Study Site

Sherman Oaks, California, United States

Study Site

Denver, Colorado, United States

Clinical Study Site

Denver, Colorado, United States

Study Site

Port Orange, Florida, United States

Clinical Study Site

Tampa, Florida, United States

Study Site

Savannah, Georgia, United States

Study Center

Arlington Heights, Illinois, United States

Clinical Study Site

South Bend, Indiana, United States

Study Center

Overland Park, Kansas, United States

Study Site

Louisville, Kentucky, United States

Clinical Study Site

Clarkston, Michigan, United States

Clinical Study Site

Clinton Township, Michigan, United States

Clinical Study Site

St Louis, Missouri, United States

Study Site

Las Vegas, Nevada, United States

Clinical Study Site

Portsmouth, New Hampshire, United States

Clinical Study Site

Berlin, New Jersey, United States

Clinical Study Site

New York, New York, United States

Clinical Study Site

Portland, Oregon, United States

Study Site

Johnston, Rhode Island, United States

Study Center

Austin, Texas, United States

Clinical Study Site

Houston, Texas, United States

Clinical Study Site

Pflugerville, Texas, United States

Clinical Study Site

San Antonio, Texas, United States

Clinical Study Site

San Antonio, Texas, United States

Study Site

San Antonio, Texas, United States

Study Site

Webster, Texas, United States

Study Center

Charlottesville, Virginia, United States

Countries

United States

Other Identifiers

CTIX-PRU-005

Identifier Type: -

Identifier Source: org_study_id