Optimal Predilatation Technique for BVS Implantation

NCT ID: NCT02946320

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2017-03-31

Brief Summary

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The purpose of this study is to determine the optimal way of predilatation for BVS implantation.

Detailed Description

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Randomized, single-center study. Forty-five patients with intended BVS implantation will be randomized in ratio of 1:1:1 to different predilatation strategies(non-compliant balloon/Emerge NC™, Boston Scientific, cutting balloon/Flexitome™, scoring balloon/Scoroflex™,Orbus). Predilatation is intended to be done in a vessel:balloon ratio of 1:1. If the device is not able enter the lesion, it will be replaced with a conventional semicompliant balloon with the same predilatation strategy (a vessel:balloon ratio of 1:1) After a successful predilatation, the BVS (Absorb™, Abbott) will be implanted and this procedure will be accomplished by a high pressure postdilatation with a non-compliant balloon (Emerge NC™, BSCI). The MLA of the Absorb stent will be evaluated with optical coherence tomography (OPTIS, St.Jude).

Conditions

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Coronary Artery Stenosis

Keywords

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PCI, bioabsorbable scaffold

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Non-compliant balloon

15 patients, before BVS implantation is coronary artery stenosis dilated with this type of balloon

Group Type ACTIVE_COMPARATOR

Predilatation with non-compliant balloon

Intervention Type DEVICE

Coronary artery stenosis is dilated before BVS implantation with the use of non-compliant balloon (standard procedure). Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Scoring balloon

15 patients, before BVS implantation is coronary artery stenosis dilated with this type of balloon

Group Type EXPERIMENTAL

Predilatation with scoring balloon (Scoroflex)

Intervention Type DEVICE

Coronary artery stenosis is dilated before BVS implantation with the use of scoring balloon. Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Cutting balloon

15 patients, before BVS implantation is coronary artery stenosis dilated with this type of balloon

Group Type EXPERIMENTAL

Predilatation with cutting balloon (Flextome)

Intervention Type DEVICE

Coronary artery stenosis is dilated before BVS implantation with the use of cutting balloon. Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Interventions

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Predilatation with non-compliant balloon

Coronary artery stenosis is dilated before BVS implantation with the use of non-compliant balloon (standard procedure). Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Intervention Type DEVICE

Predilatation with scoring balloon (Scoroflex)

Coronary artery stenosis is dilated before BVS implantation with the use of scoring balloon. Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Intervention Type DEVICE

Predilatation with cutting balloon (Flextome)

Coronary artery stenosis is dilated before BVS implantation with the use of cutting balloon. Size and dilatation pressure is done according to OCT measurement of the coronary artery (distal segment / balloon diameter = 1:1)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* patients undergoing percutaneous coronary intervention (PCI)
* lesion no more than 25 mm in length with a reference-vessel diameter of 2.5 to 3.75 mm on visual assessment

Exclusion Criteria

* patients with acurate myocardial infarction (STEMI)
* patients with specific complex lesion features (left main, aorto ostial, bifurcation with side branch ≥ 2 mm in diameter, extreme angulation proximal or within the target lesion, moderate or heavy calcification proximal or within the target lesion, chronic total occlusion)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cardiology Center Agel

OTHER

Sponsor Role lead

Responsible Party

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MUDr. Ivo Varvařovský, Ph.D

Head of Cardiology Center Agel

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ivo Varvařovský, MUDr, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Cardiology Center AGEL a.s.

Central Contacts

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Petra Jiroušková, Mgr

Role: CONTACT

Phone: +420466014182

Email: [email protected]

Other Identifiers

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RG4201601

Identifier Type: -

Identifier Source: org_study_id