High Concentration of Sugar Solution Irrigation Promotes the Healing of Infected Wound

NCT ID: NCT02945761

Last Updated: 2016-10-26

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 3 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-10-31

Brief Summary

Surgeons easily get wound infections. Most wound infections will be cured by applying medicines and changing dressing in very short period of time. But some wounds are severely contaminated combined with fat liquefaction, crateriform ulcer and large undermined lacuna, so changing dressing takes a very long time. In order to better change the dressing, it needs to expose the wound thoroughly, which requires to completely open the healed skin, so the healing will be slowed down. Some scholars lay stress on prevention. Wound infection control concerns prevention--not therapy--of an infrequent but expensive kind of surgical morbidity.(1.2)Some scholars think that the main armamentarium of the attack is the use of topical anti-infectives, which invade the bacteria where they reside, and, consequently, reduce their numbers and promote wound healing.(3)For example, silver is reemerging as a viable treatment option for infections encountered in burns, open wounds, and chronic ulcers. But it is expensive and is difficult to acquire silver-containing dressings. And Recent findings, however, indicate that the compound delays the wound-healing process and that silver may have serious cytotoxic activity on various host cells. (4) As High concentration of sugar solution, honey appears to heal partial thickness burns more quickly than conventional treatment (which included polyurethane film, paraffin gauze, soframycin-impregnated gauze, sterile linen and leaving the burns exposed) and infected post-operative wounds more quickly than antiseptics and gauze.(5)This study involve the use of another high-concentration of sugar solution (HCSS) to lavage infected wounds when changing dressings.

Conditions

Wound Infection; Sugar Solution

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

High concentration of sugar solution

Lavage group of high-concentration sugar solution (HCSS): disinfected the Skin outside wound with conventional PVP. HCSS refers to supersaturated sugar solution made of 50% high-concentration glucose and white sugar. Prior to wound irrigation, dry cotton balls are used to wipe the wound and internal lacuna, to clean some necrotic tissues out of the wound. HCSS is applied on the wound once a day, and whether the lavaging is stopped based on the amount of exudation from the wound.

Group Type: ACTIVE_COMPARATOR

High concentration of sugar solution

Intervention Type: PROCEDURE

conventional surgical dressing change

conventional surgical dressing change:separated suture, expanded the wound, placed drainage ribbon gauze and used hydrogen peroxide or(and) PVP to wash the wound; the decision-making power of these operators is determined by a doctor. After the doctor confirms granulation cleaning in the wound, the decision-making power of suture is also determined by a doctor.

Group Type: ACTIVE_COMPARATOR

conventional surgical dressing change

Intervention Type: PROCEDURE

Interventions

High concentration of sugar solution

Intervention Type: PROCEDURE

conventional surgical dressing change

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Patients conducted surgical operation in the hospital within 2 weeks. The wound had swelling and lots of secretions;

2. Except for the incision, primary surgical site has been recovered smoothly. Patients didn't accept secondary operation in the same site;

Exclusion Criteria

1. Except for the wound that can't use healthy skin closure in Phase I

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ningbo Municipal No.4 Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

weng xinhai

Director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

xinhai weng, BS

Role: STUDY_DIRECTOR

Ningbo NO.4 hospital

Other Identifiers

wengxinhai

Identifier Type: -

Identifier Source: org_study_id