Trial Outcomes & Findings for Edoxaban Treatment in Routine Clinical Practice in Patients With Venous Thromboembolism in Europe (NCT NCT02943993)

NCT ID: NCT02943993

Last Updated: 2025-04-01

Results Overview

Descriptive statistics were used to report the number of participants with at least 1 symptomatic VTE recurrence. Recurrent VTE events were based on adjudicated events. For the overall symptomatic VTE, precentage of participants (including 95% confidence intervals) were calculated.

Recruitment status

COMPLETED

Target enrollment

2809 participants

Primary outcome timeframe

Baseline up to end of observation period (18 months)

Results posted on

2025-04-01

Participant Flow

A total of 2809 participants were included in the All Documented Patient Set defined as participants with a signed ICF and trustworthy data at sites in Germany, Austria, Switzerland, Belgium, The Netherlands, United Kingdom, Ireland, and Italy; a total of 2655 participants were included in the Baseline Analysis Set and a total of 2644 participants were included in the Full Analysis Set.

Participant milestones

Participant milestones
Measure
ETNA-VTE
Participants with established initial or recurrent acute symptomatic venous thromboembolism (VTE) who were treated with edoxaban according to the Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Overall Study
STARTED
2655
Overall Study
Full Analysis Set
2644
Overall Study
COMPLETED
2325
Overall Study
NOT COMPLETED
330

Reasons for withdrawal

Reasons for withdrawal
Measure
ETNA-VTE
Participants with established initial or recurrent acute symptomatic venous thromboembolism (VTE) who were treated with edoxaban according to the Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Overall Study
Withdrawal by Subject
52
Overall Study
Transfer to another institution
6
Overall Study
Lost to Follow-up
135
Overall Study
Death
98
Overall Study
Other reason for premature termination
32
Overall Study
Missing reason for termination
7

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Age, Continuous
65.0 years
n=2644 Participants
Age, Customized
<65 years
1312 Participants
n=2644 Participants
Age, Customized
≥65 and <75 years
593 Participants
n=2644 Participants
Age, Customized
≥75 years
739 Participants
n=2644 Participants
Sex: Female, Male
Female
1231 Participants
n=2644 Participants
Sex: Female, Male
Male
1413 Participants
n=2644 Participants
Region of Enrollment
Germany
722 participants
n=2644 Participants
Region of Enrollment
Austria
182 participants
n=2644 Participants
Region of Enrollment
Switzerland
84 participants
n=2644 Participants
Region of Enrollment
Belgium
372 participants
n=2644 Participants
Region of Enrollment
Netherlands
321 participants
n=2644 Participants
Region of Enrollment
United Kingdom
113 participants
n=2644 Participants
Region of Enrollment
Ireland
17 participants
n=2644 Participants
Region of Enrollment
Italy
833 participants
n=2644 Participants

PRIMARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: VTE recurrence was assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of participants with at least 1 symptomatic VTE recurrence. Recurrent VTE events were based on adjudicated events. For the overall symptomatic VTE, precentage of participants (including 95% confidence intervals) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - Overall
3.8 Percentage of VTE recurrence
Interval 3.09 to 4.58

PRIMARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Bleeding events were assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of participants with bleeding events. For the analysis of bleeding events, absolute number of participants were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Provoked bleeding
115 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Participants with any bleeding events
304 participants
Interval 10.31 to 12.78
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
At least 1 major bleeding event
38 participants
Interval 0.99 to 1.92
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Clinically relevant non-major bleeding event
82 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Minor
300 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Gastrointestinal bleeding event
77 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Epidural or subdural haematoma bleeding event
4 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Intra-ocular bleeding event
5 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Intra-articular bleeding event
3 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Pleural bleeding event
1 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Other bleeding event
319 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Spontaneous bleeding
287 participants
Number of Participants With Bleeding Events (Adjudicated) While On Edoxaban Treatment
Unknown bleeding
18 participants

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Real word safety events were assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of participants experiencing recurrent VTE and at least 1 real world safety event. VTE recurrence data were reported by recurrent deep vein thrombosis (DVT), recurrent pulmonary embolism (PE) with DVT, and recurrent PE only. Recurrent VTE events were based on adjudicated events. Real world safety events included all-cause death, cardiovascular (CV)-related death, VTE-related death, stroke, systemic embolic event, and hospitalization related to CV. For recurrent VTE and real world safety events, absolute and relative frequencies (including 95% confidence intervals) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Recurrent DVT only
2.3 Percentage of real world safety events
Interval 1.77 to 2.95
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Recurrent PE with DVT
0.3 Percentage of real world safety events
Interval 0.11 to 0.54
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Recurrent PE only
1.2 Percentage of real world safety events
Interval 0.8 to 1.66
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
All-cause death
3.6 Percentage of real world safety events
Interval 2.92 to 4.37
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Cardiovascular-related death
0.9 Percentage of real world safety events
Interval 0.55 to 1.3
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Venous thromboembolism-related death
0 Percentage of real world safety events
Interval 0.0 to 0.21
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Stroke
1.0 Percentage of real world safety events
Interval 0.64 to 1.44
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Systemic embolic event
0.1 Percentage of real world safety events
Interval 0.01 to 0.27
Percentage of Participants Experiencing At Least 1 Real World Safety Event - Overall
Hospitalization related to CV
9.6 Percentage of real world safety events
Interval 8.47 to 10.75

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: VTE recurrence was assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of participants with overall symptomatic VTE recurrence. VTE recurrence data were further reported by recurrent deep venous thrombosis (DVT), recurrent pulmonary embolism (PE) with deep venous thrombosis (DVT), and recurrent PE only. Recurrent VTE events were based on adjudicated events. For symptomatic VTE recurrence, percentage of participants (95% confidence intervals) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
VTE-related death
0 Percentage of VTE recurrence
Interval 0.0 to 0.21
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Recurrent VTE
1.4 Percentage of VTE recurrence
Interval 0.99 to 1.92
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Recurrent DVT only
1.0 Percentage of VTE recurrence
Interval 0.67 to 1.48
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Recurrent PE with DVT
0 Percentage of VTE recurrence
Interval 0.0 to 0.21
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Recurrent PE only
0.3 Percentage of VTE recurrence
Interval 0.16 to 0.65
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
All-cause death
1.9 Percentage of VTE recurrence
Interval 1.41 to 2.49
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
CV-related death
0.4 Percentage of VTE recurrence
Interval 0.21 to 0.74
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Stroke
0.6 Percentage of VTE recurrence
Interval 0.32 to 0.93
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Systemic embolic event
0 Percentage of VTE recurrence
Interval 0.0 to 0.21
Percentage of Participants With At Least 1 Symptomatic Venous Thromboembolism Recurrence - On Edoxaban Treatment
Hospitalization-related to cardiovascular
6.3 Percentage of VTE recurrence
Interval 5.42 to 7.31

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Number of VTE recurrences were assessed in the Full Analysis Set.

Descriptive statistics were used to describe the number of VTE events reported by the patient. For VTE recurrences, absolute number of VTE events were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Total Number of Venous Thromboembolism Recurrences By Type - Overall
Total number of VTE recurrences
105 VTE recurrences
Total Number of Venous Thromboembolism Recurrences By Type - Overall
Deep vein thrombosis (DVT) only
64 VTE recurrences
Total Number of Venous Thromboembolism Recurrences By Type - Overall
Pulmonary embolism with DVT
7 VTE recurrences
Total Number of Venous Thromboembolism Recurrences By Type - Overall
Pulmonary embolism only
32 VTE recurrences

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Duration of VTE recurrences was assessed in patients with available start and stop data in the Full Analysis Set.

Descriptive statistics were used to assess the duration of VTE events reported by the patient. For VTE recurrences, median duration of VTE events (interquartile range) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Duration of Venous Thromboembolism Recurrences, by Type - Overall
Total number of VTE recurrences
18.0 days
Interval 8.0 to 93.0
Duration of Venous Thromboembolism Recurrences, by Type - Overall
Deep vein thrombosis (DVT) only
44.5 days
Interval 8.0 to 95.0
Duration of Venous Thromboembolism Recurrences, by Type - Overall
Pulmonary embolism with DVT
8.0 days
Interval 5.0 to 146.0
Duration of Venous Thromboembolism Recurrences, by Type - Overall
Pulmonary embolism only
16.0 days
Interval 8.0 to 93.0

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Number of VTE recurrences were assessed in the Full Analysis Set.

Descriptive statistics were used to assess the number of recurrent VTE events reported by the patient. For VTE recurrences, absolute number of VTE recurrences were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Total Number of Venous Thromboembolism Recurrences (On Edoxaban Treatment)
Total number of VTE recurrences
39 VTE recurrences
Total Number of Venous Thromboembolism Recurrences (On Edoxaban Treatment)
Deep vein thrombosis (DVT) only
28 VTE recurrences
Total Number of Venous Thromboembolism Recurrences (On Edoxaban Treatment)
Pulmonary embolism with DVT
1 VTE recurrences
Total Number of Venous Thromboembolism Recurrences (On Edoxaban Treatment)
Pulmonary embolism only
9 VTE recurrences

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Duration of VTE recurrences was assessed in patients with available start and stop data in the Full Analysis Set.

Descriptive statistics were used to assess the duration of VTE events reported by the patient. For VTE events, median duration of VTE events (interquartile range) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Duration of Venous Thromboembolism Events (On Edoxaban Treatment)
Total number of VTE recurrences
11.0 days
Interval 8.0 to 20.0
Duration of Venous Thromboembolism Events (On Edoxaban Treatment)
Deep vein thrombosis (DVT) only
9.5 days
Interval 8.0 to 20.0
Duration of Venous Thromboembolism Events (On Edoxaban Treatment)
Pulmonary embolism with DVT
0 days
Interval 0.0 to 0.0
Duration of Venous Thromboembolism Events (On Edoxaban Treatment)
Pulmonary embolism only
15.0 days
Interval 8.0 to 16.0

SECONDARY outcome

Timeframe: at Baseline

Population: Risk factors were assessed in the Full Analysis Set.

Descriptive statistics were used to assess the number of participants with risk factors for thromboembolic events. For risk factors for thromboembolic events, absolute number of participants with risk factors (percentage) were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Participants With Risk Factors for Thromboembolic Events at Baseline
Puerperium
9 Participants
Number of Participants With Risk Factors for Thromboembolic Events at Baseline
Prolonged immobilisation
401 Participants
Number of Participants With Risk Factors for Thromboembolic Events at Baseline
>5 days in bed
218 Participants
Number of Participants With Risk Factors for Thromboembolic Events at Baseline
History of major surgery trauma
359 Participants
Number of Participants With Risk Factors for Thromboembolic Events at Baseline
Known thrombophilic conditions
111 Participants

SECONDARY outcome

Timeframe: Baseline up to end of observational period (18 months)

Population: Duration of edoxaban treatment was assessed in the Full Analysis Set.

Descriptive statistics were used to report the duration of edoxaban treatment.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Duration of Edoxaban Treatment
Month 6 ongoing
1842 Participants
Duration of Edoxaban Treatment
Month 12 ongoing
1272 Participants
Duration of Edoxaban Treatment
Month 18 ongoing
713 Participants
Duration of Edoxaban Treatment
Month 1 ongoing
2527 Participants
Duration of Edoxaban Treatment
Month 3 ongoing
2346 Participants
Duration of Edoxaban Treatment
Participants off edoxaban treatment at 18 months
1910 Participants

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Stroke events were assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of stroke events. For stroke events, absolute number of stroke events were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Stroke Events
On treatment: Total number of stroke events
16 events
Number of Stroke Events
Overall treatment: Total number of stroke events
27 events
Number of Stroke Events
Overall treatment: Ischemic events
17 events
Number of Stroke Events
Overall treatment: Haemorrhagic events
5 events
Number of Stroke Events
Overall treatment: Unknown events
5 events
Number of Stroke Events
On treatment: Ischemic events
12 events
Number of Stroke Events
On treatment: Haemorrhagic events
3 events
Number of Stroke Events
On treatment: Unknown events
1 events

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Systemic embolic events were assessed in the Full Analysis Set.

Descriptive statistics were used to report the number of systemic embolic events (SEE). For SEE, absolute SEEs were calculated.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2644 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Systemic Embolic Events - Overall
Upper/lower extremity
1 Systemic embolic events
Number of Systemic Embolic Events - Overall
Renal
1 Systemic embolic events

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Adverse drug reactions were assessed in the Baseline Analysis Set.

Descriptive statistics were used to report an overview of participants with adverse drug reactions (ADR). ADRs were coded using the Medical Dictionary for Regulatory Activities (MedDRA) version 20.1.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2655 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Overview of Participants With Adverse Drug Reactions
Death due to ADR
2 Participants
Overview of Participants With Adverse Drug Reactions
Participants with at least 1 ADR
142 Participants
Overview of Participants With Adverse Drug Reactions
Participants with at least 1 serious ADR
59 Participants
Overview of Participants With Adverse Drug Reactions
Study discontinuation due to ADR
0 Participants

SECONDARY outcome

Timeframe: Baseline up to end of observational period (18 months)

Population: Adverse drug reactions were assessed in the Baseline Analysis Set.

Adverse drug reactions were reported and coded using the Medical Dictionary for Regulatory Activities (MedDRA) version 20.1.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2655 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Haemorrhage
35 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Gastrointestinal haemorrhage
12 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Menorrhagia
12 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Epistaxis
11 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Fatigue
8 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Nausea
8 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Dizziness
7 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Rash
7 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Headache
5 Participants
Number of Participants With Adverse Drug Reactions by Preferred Term (≥0.2%)
Pruritus
5 Participants

SECONDARY outcome

Timeframe: Baseline up to end of observation period (18 months)

Population: Adverse drug reactions were assessed in the Baseline Analysis Set.

Descriptive statistics were used to report the number of participants with pre-defined adverse drug reactions (ADR). ADRs were coded using the Medical Dictionary for Regulatory Activities (MedDRA) version 20.1.

Outcome measures

Outcome measures
Measure
ETNA-VTE
n=2655 Participants
Participants with established acute initial or recurrent VTE who were treated with edoxaban according to Summary of Product Characteristics (SmPC) based on the clinical decision of the treating physician.
Number of Participants With Pre-defined Adverse Drug Reactions
Systemic embolic events
0 Participants
Number of Participants With Pre-defined Adverse Drug Reactions
Stroke
2 Participants
Number of Participants With Pre-defined Adverse Drug Reactions
Bleeding events
75 Participants
Number of Participants With Pre-defined Adverse Drug Reactions
Non-valvular atrial fibrillation
0 Participants
Number of Participants With Pre-defined Adverse Drug Reactions
Malignancy
0 Participants
Number of Participants With Pre-defined Adverse Drug Reactions
Others
4 Participants

Adverse Events

ETNA-VTE

Serious events: 0 serious events
Other events: 0 other events
Deaths: 98 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Contact for Clinical Trial Information

Daiichi Sankyo

Phone: 908-992-6400

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place