Determining of Normal Values and Conformity Assessment of the Dosage of a Plasmatic Marker of the Cellular Captation of Glucose: the IRAP Protein

NCT ID: NCT02941874

Last Updated: 2020-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-07

Study Completion Date

2019-12-12

Brief Summary

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The purpose of this study is on one hand to verify the measurement conformity of the IRAP dosage and on the other hand to obtain normal values of the blood IRAP concentration on healthy volunteers.

Detailed Description

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This study consists of two visits, from two to five days apart.

The first visit :

* Healthy volunteers will be on an empty stomach.
* they will have a clinical examination, blood tests and blood samples will be taken to constitute a blood collection. the IRAP concentration will be measured with those samples.

The second visit : This visit will take place in an interval from 2 to 5 days after the first visit.

* Subjects will be on an empty stomach
* An oral glucose tolerance test (OGTT) of 3 hours will be performed. Blood samples will be taken three time 15 minutes apart at Baseline (before taking the glucose). And then after the glucose intake, blood sample will be taken every 15 minutes to measure insulinemia, blood glucose, and IRAP concentration.

Conditions

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Insulin Resistance

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy volunteers IRAP measurement

Blood sample collection during an OGTT to assess IRAP blood concentration

Intervention Type OTHER

Blood sample collection during an OGTT to assess IRAP blood concentration. Blood samples will be collected every 15 minutes during 3 hours

Interventions

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Blood sample collection during an OGTT to assess IRAP blood concentration

Blood sample collection during an OGTT to assess IRAP blood concentration. Blood samples will be collected every 15 minutes during 3 hours

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Body mass index between 19 and 25 Kg/m²
* No intercurrent disease during the last week
* No chronic infectious disease
* No smoker, no alcoholic

Exclusion Criteria

* history of : thyroid disease, liver or renal disease, endocrine and metabolic disease, cardiovascular disease, lung disease, gastroenterological disorders, psychiatric disease, Epilepsy
* Consumption of narcotic drug
* Blood donation dating less than 2 months
* Pregnancy or breast-feeding, or intent to become pregnant during the study period
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Institut de Biologie - Pathologie

Grenoble, Isere, France

Site Status

Countries

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France

Other Identifiers

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38RC16.131

Identifier Type: -

Identifier Source: org_study_id