Assessing the Effects of Three Oral Care Regimens

NCT ID: NCT02940821

Last Updated: 2017-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-30

Study Completion Date

2017-07-27

Brief Summary

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Assessing the effects of three oral care regimen on plaque, gingivitis, and tooth whitening: A randomized, person-centric, comparative effectiveness clinical research study by the Practitioners Engaged in Applied Research and Learning (PEARL) Network.

Detailed Description

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Six month, five visit study of plaque, gingivitis, and tooth whitening with three randomized intervention groups using FDA marketed and approved products and devices. One hundred fifty (150) subjects from the patient base of 10 PEARL Network associated dental offices on the East Coast of the United States will be entered into the clinical research study. This is a post-marketing comparative effectiveness research study. Having a total of 5 visits over a six month period. Adverse events and side effects for the products used are being assessed.

Conditions

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Dental Plaque Gingivitis

Keywords

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Tooth Whitening

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Whitening and Dentifrice

Group Type ACTIVE_COMPARATOR

Toothbrushing

Intervention Type OTHER

Mechanical plaque removal

Whitening (4.5% hydrogen peroxide)

Intervention Type OTHER

Application of Whitening Agent

Other Fluoridated Dentifrice (.454% stannous fluoride)

Intervention Type OTHER

Fluoridated dentifrice application

Whitening Dentifrice

Group Type ACTIVE_COMPARATOR

Toothbrushing

Intervention Type OTHER

Mechanical plaque removal

Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide)

Intervention Type OTHER

Application of Tooth Whitening Agent in Dentifrice

Dentifrice

Group Type ACTIVE_COMPARATOR

Toothbrushing

Intervention Type OTHER

Mechanical plaque removal

Fluoridated Dentifrice (.15% sodium monofluorophosphate)

Intervention Type OTHER

Fluoridated dentifrice application

Interventions

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Toothbrushing

Mechanical plaque removal

Intervention Type OTHER

Fluoridated Dentifrice (.15% sodium monofluorophosphate)

Fluoridated dentifrice application

Intervention Type OTHER

Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide)

Application of Tooth Whitening Agent in Dentifrice

Intervention Type OTHER

Whitening (4.5% hydrogen peroxide)

Application of Whitening Agent

Intervention Type OTHER

Other Fluoridated Dentifrice (.454% stannous fluoride)

Fluoridated dentifrice application

Intervention Type OTHER

Other Intervention Names

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Toothbrush Fluoridated Dentifrice Whitening System (.454% stannous fluoride with 2% hydrogen peroxide) and toothbrushing Fluoridated dentifrice (.454% stannous fluoride)

Eligibility Criteria

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Inclusion Criteria

1. Subject males or females 18 to 70 years old (inclusive).
2. Availability for the 6 months duration of the clinical research study
3. Good general health
4. Subject able and willing to follow study procedures and instructions
5. Subject read, understood and signed an informed consent form
6. Subject present with at least 20 natural teeth in the functional dentition (excluding third molars), including the following natural (uncrowned) teeth for shading: #6, #7, #8, #9, #10, #11

Exclusion Criteria

Potential subjects must NOT HAVE ANY of the following conditions:

1. Presence of orthodontic bands
2. Presence of partial removable dentures
3. Tumor(s) of the soft or hard tissues of the oral cavity
4. Restorations or crowns that would interfere with color measurements on the following teeth: #6, #7, #8 , #9, #10 \& #11 (upper six front teeth)
5. Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone)
6. Five or more carious lesions requiring immediate restorative treatment
7. Antibiotic use any time during the one month prior to entry into the study
8. Participation in any other clinical study or test panel within the one month prior to entry into the study
9. History of allergies to oral care/personal care consumer products or their ingredients.
10. On any prescription medicines that might interfere with the study outcome
11. An existing medical condition which prohibits eating or drinking for periods up to 4 hours
12. History of alcohol or drug abuse
13. Pregnant or lactating
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pearl Network

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Frederick A Curro, DMD, PhD

Role: STUDY_DIRECTOR

Pearl Network

Ashley C Grill, MPH, RDH

Role: PRINCIPAL_INVESTIGATOR

Pearl Network

Locations

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Frederick A. Curro, DMD, PhD

Emerson, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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PRL1517

Identifier Type: -

Identifier Source: org_study_id