Machine Learning for Identification of Future Disease Development: A Nationwide Cohort Study (MILESTONE)

NCT ID: NCT02931500

Last Updated: 2018-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

510000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-07-01

Study Completion Date

2018-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To develop machine learning algorithms for the identification of future development of cardiovascular and metabolic disease

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The MILESTONE trial is retrospective and data review study with health checkup data from the National Health Insurance Services(NHIS) in Korea. The data will be included general health examination for individuals , type of health insurance, medical bill details, medical histories, treatment and prescriptions about 514,795 individuals who were over 40 years old.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiovascular Disease Metabolic Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* The Subject who is got health checkup between 2002 and 2013, and had been recorded the health checkup result to the National Health Insurance Service(NHIS) in South Korea.

Exclusion Criteria

* Persons whose disease development is not identified from the records due to emigration or disappearance
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Yonsei University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Hyuk-Jae Chang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Hyuk-Jae Chang, PhD

Role: PRINCIPAL_INVESTIGATOR

Yonsei Univerity

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Yonsei University Severance Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

South Korea

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Hyuk-Jae Chang, PhD

Role: CONTACT

In-Jeong Cho

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Hyuk-Jae Chang, MD

Role: primary

82-2-2228-8454

References

Explore related publications, articles, or registry entries linked to this study.

Cho IJ, Sung JM, Kim HC, Lee SE, Chae MH, Kavousi M, Rueda-Ochoa OL, Ikram MA, Franco OH, Min JK, Chang HJ. Development and External Validation of a Deep Learning Algorithm for Prognostication of Cardiovascular Outcomes. Korean Circ J. 2020 Jan;50(1):72-84. doi: 10.4070/kcj.2019.0105. Epub 2019 Aug 19.

Reference Type DERIVED
PMID: 31456363 (View on PubMed)

Cho IJ, Sung JM, Chang HJ, Chung N, Kim HC. Incremental Value of Repeated Risk Factor Measurements for Cardiovascular Disease Prediction in Middle-Aged Korean Adults: Results From the NHIS-HEALS (National Health Insurance System-National Health Screening Cohort). Circ Cardiovasc Qual Outcomes. 2017 Nov;10(11):e004197. doi: 10.1161/CIRCOUTCOMES.117.004197.

Reference Type DERIVED
PMID: 29150537 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

4-2016-0383

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Predictive Medicine Research
NCT00384761 COMPLETED